Effect of prothrombotic genotypes on the risk of venous thromboembolism in patients with and without ischemic stroke: The Tromso Study
Background Patients with ischemic stroke have a transiently increased risk of subsequent venous thromboembolism (VTE). Prothrombotic genotypes may augment VTE risk under conditions of high thrombosis risk related to stroke. Aims To investigate the effect of prothrombotic genotypes in patients with i...
Published in: | Journal of Thrombosis and Haemostasis |
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Wiley-Blackwell Publishing Ltd.
2019
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Online Access: | https://doi.org/10.1111/jth.14410 |
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ftaustraliancuni:oai:acuresearchbank.acu.edu.au:867q4 2023-09-05T13:23:45+02:00 Effect of prothrombotic genotypes on the risk of venous thromboembolism in patients with and without ischemic stroke: The Tromso Study Rinde, Ludvig B. Morelli, Vania M. Småbrekke, Birgit Mathiesen, Ellisiv Bøgeberg Løchen, Maja-Lisa Njølstad, Inger Wilsgaard, Tom Smith, Erin F. Rosendaal, Frits R. Frazer, Kelly A. Brækkan, Sigrid Kufaas Hansen, John-Bjarne 2019 https://doi.org/10.1111/jth.14410 unknown Wiley-Blackwell Publishing Ltd. https://acuresearchbank.acu.edu.au/item/867q4/effect-of-prothrombotic-genotypes-on-the-risk-of-venous-thromboembolism-in-patients-with-and-without-ischemic-stroke-the-tromso-study ISSN:1538-7933 https://doi.org/10.1111/jth.14410 Rinde, Ludvig B., Morelli, Vania M., Småbrekke, Birgit, Mathiesen, Ellisiv Bøgeberg, Løchen, Maja-Lisa, Njølstad, Inger, Wilsgaard, Tom, Smith, Erin F., Rosendaal, Frits R., Frazer, Kelly A., Brækkan, Sigrid Kufaas and Hansen, John-Bjarne. (2019). Effect of prothrombotic genotypes on the risk of venous thromboembolism in patients with and without ischemic stroke: The Tromso Study. Journal of Thrombosis and Haemostasis. 17(5), pp. 749 - 758. https://doi.org/10.1111/jth.14410 epidemiology genetics risk factors stroke venous thromboembolism journal-article 2019 ftaustraliancuni https://doi.org/10.1111/jth.14410 2023-08-11T15:38:49Z Background Patients with ischemic stroke have a transiently increased risk of subsequent venous thromboembolism (VTE). Prothrombotic genotypes may augment VTE risk under conditions of high thrombosis risk related to stroke. Aims To investigate the effect of prothrombotic genotypes in patients with ischemic stroke on the risk of VTE in a population‐based case–cohort study. Methods Cases with incident VTE (n = 664) and a randomly selected age‐weighted subcohort (n = 1817) were sampled from three surveys of the Tromsø Study (1994–2008). Participants were genotyped for ABO (rs8176719), F5 (rs6025), F2 (rs1799963), FGG (rs2066865) and F11 (rs2036914) single‐nucleotide polymorphisms (SNPs). Cox regression models were used to calculate hazard ratios (HRs) for incident VTE according to individual SNPs and categories of risk alleles (5‐SNP score; 0–1, 2, 3–4 and ≥ 5) in participants with and without ischemic stroke. Results There were 192 patients with incident stroke, of whom 43 developed VTE during a median of 15.2 years of follow‐up. The risk alleles of individual SNPs augmented the elevated VTE risk brought about by ischemic stroke. In stroke patients, a one‐category increase in the genetic risk score was associated with a 50% higher relative risk of overall VTE (HR 1.5, 95% confidence interval [CI] 1.3–1.8) and an 80% higher relative risk of provoked VTE (HR 1.8, 95% CI 1.5–2.1). Stroke patients with ≥ 5 risk alleles had a 12‐fold (HR 11.7, 95% CI 4.1–33.3) higher relative risk of VTE than stroke‐free participants with 0–1 risk alleles. Conclusions Prothrombotic genotypes increased the risk of VTE in stroke patients, and the risk increased with an increasing number of risk alleles. Article in Journal/Newspaper Tromso Tromso Tromsø Australian Catholic University: ACU Research Bank Tromso ENVELOPE(16.546,16.546,68.801,68.801) Tromsø Journal of Thrombosis and Haemostasis 17 5 749 758 |
institution |
Open Polar |
collection |
Australian Catholic University: ACU Research Bank |
op_collection_id |
ftaustraliancuni |
language |
unknown |
topic |
epidemiology genetics risk factors stroke venous thromboembolism |
spellingShingle |
epidemiology genetics risk factors stroke venous thromboembolism Rinde, Ludvig B. Morelli, Vania M. Småbrekke, Birgit Mathiesen, Ellisiv Bøgeberg Løchen, Maja-Lisa Njølstad, Inger Wilsgaard, Tom Smith, Erin F. Rosendaal, Frits R. Frazer, Kelly A. Brækkan, Sigrid Kufaas Hansen, John-Bjarne Effect of prothrombotic genotypes on the risk of venous thromboembolism in patients with and without ischemic stroke: The Tromso Study |
topic_facet |
epidemiology genetics risk factors stroke venous thromboembolism |
description |
Background Patients with ischemic stroke have a transiently increased risk of subsequent venous thromboembolism (VTE). Prothrombotic genotypes may augment VTE risk under conditions of high thrombosis risk related to stroke. Aims To investigate the effect of prothrombotic genotypes in patients with ischemic stroke on the risk of VTE in a population‐based case–cohort study. Methods Cases with incident VTE (n = 664) and a randomly selected age‐weighted subcohort (n = 1817) were sampled from three surveys of the Tromsø Study (1994–2008). Participants were genotyped for ABO (rs8176719), F5 (rs6025), F2 (rs1799963), FGG (rs2066865) and F11 (rs2036914) single‐nucleotide polymorphisms (SNPs). Cox regression models were used to calculate hazard ratios (HRs) for incident VTE according to individual SNPs and categories of risk alleles (5‐SNP score; 0–1, 2, 3–4 and ≥ 5) in participants with and without ischemic stroke. Results There were 192 patients with incident stroke, of whom 43 developed VTE during a median of 15.2 years of follow‐up. The risk alleles of individual SNPs augmented the elevated VTE risk brought about by ischemic stroke. In stroke patients, a one‐category increase in the genetic risk score was associated with a 50% higher relative risk of overall VTE (HR 1.5, 95% confidence interval [CI] 1.3–1.8) and an 80% higher relative risk of provoked VTE (HR 1.8, 95% CI 1.5–2.1). Stroke patients with ≥ 5 risk alleles had a 12‐fold (HR 11.7, 95% CI 4.1–33.3) higher relative risk of VTE than stroke‐free participants with 0–1 risk alleles. Conclusions Prothrombotic genotypes increased the risk of VTE in stroke patients, and the risk increased with an increasing number of risk alleles. |
format |
Article in Journal/Newspaper |
author |
Rinde, Ludvig B. Morelli, Vania M. Småbrekke, Birgit Mathiesen, Ellisiv Bøgeberg Løchen, Maja-Lisa Njølstad, Inger Wilsgaard, Tom Smith, Erin F. Rosendaal, Frits R. Frazer, Kelly A. Brækkan, Sigrid Kufaas Hansen, John-Bjarne |
author_facet |
Rinde, Ludvig B. Morelli, Vania M. Småbrekke, Birgit Mathiesen, Ellisiv Bøgeberg Løchen, Maja-Lisa Njølstad, Inger Wilsgaard, Tom Smith, Erin F. Rosendaal, Frits R. Frazer, Kelly A. Brækkan, Sigrid Kufaas Hansen, John-Bjarne |
author_sort |
Rinde, Ludvig B. |
title |
Effect of prothrombotic genotypes on the risk of venous thromboembolism in patients with and without ischemic stroke: The Tromso Study |
title_short |
Effect of prothrombotic genotypes on the risk of venous thromboembolism in patients with and without ischemic stroke: The Tromso Study |
title_full |
Effect of prothrombotic genotypes on the risk of venous thromboembolism in patients with and without ischemic stroke: The Tromso Study |
title_fullStr |
Effect of prothrombotic genotypes on the risk of venous thromboembolism in patients with and without ischemic stroke: The Tromso Study |
title_full_unstemmed |
Effect of prothrombotic genotypes on the risk of venous thromboembolism in patients with and without ischemic stroke: The Tromso Study |
title_sort |
effect of prothrombotic genotypes on the risk of venous thromboembolism in patients with and without ischemic stroke: the tromso study |
publisher |
Wiley-Blackwell Publishing Ltd. |
publishDate |
2019 |
url |
https://doi.org/10.1111/jth.14410 |
long_lat |
ENVELOPE(16.546,16.546,68.801,68.801) |
geographic |
Tromso Tromsø |
geographic_facet |
Tromso Tromsø |
genre |
Tromso Tromso Tromsø |
genre_facet |
Tromso Tromso Tromsø |
op_relation |
https://acuresearchbank.acu.edu.au/item/867q4/effect-of-prothrombotic-genotypes-on-the-risk-of-venous-thromboembolism-in-patients-with-and-without-ischemic-stroke-the-tromso-study ISSN:1538-7933 https://doi.org/10.1111/jth.14410 Rinde, Ludvig B., Morelli, Vania M., Småbrekke, Birgit, Mathiesen, Ellisiv Bøgeberg, Løchen, Maja-Lisa, Njølstad, Inger, Wilsgaard, Tom, Smith, Erin F., Rosendaal, Frits R., Frazer, Kelly A., Brækkan, Sigrid Kufaas and Hansen, John-Bjarne. (2019). Effect of prothrombotic genotypes on the risk of venous thromboembolism in patients with and without ischemic stroke: The Tromso Study. Journal of Thrombosis and Haemostasis. 17(5), pp. 749 - 758. https://doi.org/10.1111/jth.14410 |
op_doi |
https://doi.org/10.1111/jth.14410 |
container_title |
Journal of Thrombosis and Haemostasis |
container_volume |
17 |
container_issue |
5 |
container_start_page |
749 |
op_container_end_page |
758 |
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1776204337274421248 |