Association between diastolic dysfunction and future atrial fibrillation in the Tromso Study from 1994 to 2010
Objective To investigate the association between echocardiographic measurements with emphasis on diastolic dysfunction and risk of atrial fibrillation (AF) in a population-based cohort study. Methods We followed 2406 participants from the Tromsø Study from 1994 to 2010. Left atrial (LA) size and mit...
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B M J Group
2015
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Online Access: | https://acuresearchbank.acu.edu.au/download/320162ec392a31d3967f71faf27fd3859d479bfc4d054ada72a2709eb81e4b05/1203834/OA_Tiwari_2015_Association_between_diastolic_dysfunction_and_future.pdf https://doi.org/10.1136/heartjnl-2015-307438 |
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ftaustraliancuni:oai:acuresearchbank.acu.edu.au:860x7 2023-09-05T13:23:45+02:00 Association between diastolic dysfunction and future atrial fibrillation in the Tromso Study from 1994 to 2010 Tiwari, Sweta Schirmer, Henrik Jacobsen, Bjarne K. Hopstock, Laila Arnesdatter Nyrnes, Audhild Heggelund, Geir Njolstad, I Mathiesen, E. B. Loechen, Maja-Lisa 2015 application/pdf https://acuresearchbank.acu.edu.au/download/320162ec392a31d3967f71faf27fd3859d479bfc4d054ada72a2709eb81e4b05/1203834/OA_Tiwari_2015_Association_between_diastolic_dysfunction_and_future.pdf https://doi.org/10.1136/heartjnl-2015-307438 unknown B M J Group https://acuresearchbank.acu.edu.au/item/860x7/association-between-diastolic-dysfunction-and-future-atrial-fibrillation-in-the-tromso-study-from-1994-to-2010 ISSN:1355-6037 https://acuresearchbank.acu.edu.au/download/320162ec392a31d3967f71faf27fd3859d479bfc4d054ada72a2709eb81e4b05/1203834/OA_Tiwari_2015_Association_between_diastolic_dysfunction_and_future.pdf https://doi.org/10.1136/heartjnl-2015-307438 Tiwari, Sweta, Schirmer, Henrik, Jacobsen, Bjarne K., Hopstock, Laila Arnesdatter, Nyrnes, Audhild, Heggelund, Geir, Njolstad, I, Mathiesen, E. B. and Loechen, Maja-Lisa. (2015). Association between diastolic dysfunction and future atrial fibrillation in the Tromso Study from 1994 to 2010. Heart. 101(16), pp. 1302 - 1308. https://doi.org/10.1136/heartjnl-2015-307438 CC BY-NC 4.0 journal-article 2015 ftaustraliancuni https://doi.org/10.1136/heartjnl-2015-307438 2023-08-11T15:45:16Z Objective To investigate the association between echocardiographic measurements with emphasis on diastolic dysfunction and risk of atrial fibrillation (AF) in a population-based cohort study. Methods We followed 2406 participants from the Tromsø Study from 1994 to 2010. Left atrial (LA) size and mitral Doppler indices as measured by echocardiography were used for evaluating diastolic dysfunction. Information concerning age, systolic blood pressure, height, heart rate, body mass index, total and high-density lipoprotein cholesterol, self-reported use of alcohol, smoking, coffee, physical activity, antihypertensive treatment, prevalent coronary heart disease, valvular heart disease, heart failure, hypertrophy, diabetes and palpitations were obtained at baseline. The outcome measure was clinical AF, documented by an ECG. Results AF was detected in 462 subjects (193 women). Mean age at baseline was 62.6 years. Incidence rate of clinical AF was 12.6 per 1000 person-years. In multivariable Cox proportional hazards regression analysis, moderately enlarged LA was associated with 60% (95% CI 1.2 to 2.0) increased risk of AF. Severely enlarged LA had HR for AF of 4.2 (95% CI 2.7 to 6.5) with p value for linear trend <0.001, and the association was similar in both sexes. Abnormal mitral Doppler flow adjusted for predictor variables did not show a statistically significant association with AF risk. However, when LA size was also adjusted for, the risk of AF increased by 30% (95% CI 1.0 to 1.6). Conclusions Our findings suggest that enlarged LA as a measure for diastolic dysfunction is a significant risk factor for AF in both sexes, and adding measures of abnormal diastolic flow increased the predictive ability significantly. Article in Journal/Newspaper Tromso Tromso Tromsø Australian Catholic University: ACU Research Bank Tromso ENVELOPE(16.546,16.546,68.801,68.801) Tromsø Heart 101 16 1302 1308 |
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Open Polar |
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Australian Catholic University: ACU Research Bank |
op_collection_id |
ftaustraliancuni |
language |
unknown |
description |
Objective To investigate the association between echocardiographic measurements with emphasis on diastolic dysfunction and risk of atrial fibrillation (AF) in a population-based cohort study. Methods We followed 2406 participants from the Tromsø Study from 1994 to 2010. Left atrial (LA) size and mitral Doppler indices as measured by echocardiography were used for evaluating diastolic dysfunction. Information concerning age, systolic blood pressure, height, heart rate, body mass index, total and high-density lipoprotein cholesterol, self-reported use of alcohol, smoking, coffee, physical activity, antihypertensive treatment, prevalent coronary heart disease, valvular heart disease, heart failure, hypertrophy, diabetes and palpitations were obtained at baseline. The outcome measure was clinical AF, documented by an ECG. Results AF was detected in 462 subjects (193 women). Mean age at baseline was 62.6 years. Incidence rate of clinical AF was 12.6 per 1000 person-years. In multivariable Cox proportional hazards regression analysis, moderately enlarged LA was associated with 60% (95% CI 1.2 to 2.0) increased risk of AF. Severely enlarged LA had HR for AF of 4.2 (95% CI 2.7 to 6.5) with p value for linear trend <0.001, and the association was similar in both sexes. Abnormal mitral Doppler flow adjusted for predictor variables did not show a statistically significant association with AF risk. However, when LA size was also adjusted for, the risk of AF increased by 30% (95% CI 1.0 to 1.6). Conclusions Our findings suggest that enlarged LA as a measure for diastolic dysfunction is a significant risk factor for AF in both sexes, and adding measures of abnormal diastolic flow increased the predictive ability significantly. |
format |
Article in Journal/Newspaper |
author |
Tiwari, Sweta Schirmer, Henrik Jacobsen, Bjarne K. Hopstock, Laila Arnesdatter Nyrnes, Audhild Heggelund, Geir Njolstad, I Mathiesen, E. B. Loechen, Maja-Lisa |
spellingShingle |
Tiwari, Sweta Schirmer, Henrik Jacobsen, Bjarne K. Hopstock, Laila Arnesdatter Nyrnes, Audhild Heggelund, Geir Njolstad, I Mathiesen, E. B. Loechen, Maja-Lisa Association between diastolic dysfunction and future atrial fibrillation in the Tromso Study from 1994 to 2010 |
author_facet |
Tiwari, Sweta Schirmer, Henrik Jacobsen, Bjarne K. Hopstock, Laila Arnesdatter Nyrnes, Audhild Heggelund, Geir Njolstad, I Mathiesen, E. B. Loechen, Maja-Lisa |
author_sort |
Tiwari, Sweta |
title |
Association between diastolic dysfunction and future atrial fibrillation in the Tromso Study from 1994 to 2010 |
title_short |
Association between diastolic dysfunction and future atrial fibrillation in the Tromso Study from 1994 to 2010 |
title_full |
Association between diastolic dysfunction and future atrial fibrillation in the Tromso Study from 1994 to 2010 |
title_fullStr |
Association between diastolic dysfunction and future atrial fibrillation in the Tromso Study from 1994 to 2010 |
title_full_unstemmed |
Association between diastolic dysfunction and future atrial fibrillation in the Tromso Study from 1994 to 2010 |
title_sort |
association between diastolic dysfunction and future atrial fibrillation in the tromso study from 1994 to 2010 |
publisher |
B M J Group |
publishDate |
2015 |
url |
https://acuresearchbank.acu.edu.au/download/320162ec392a31d3967f71faf27fd3859d479bfc4d054ada72a2709eb81e4b05/1203834/OA_Tiwari_2015_Association_between_diastolic_dysfunction_and_future.pdf https://doi.org/10.1136/heartjnl-2015-307438 |
long_lat |
ENVELOPE(16.546,16.546,68.801,68.801) |
geographic |
Tromso Tromsø |
geographic_facet |
Tromso Tromsø |
genre |
Tromso Tromso Tromsø |
genre_facet |
Tromso Tromso Tromsø |
op_relation |
https://acuresearchbank.acu.edu.au/item/860x7/association-between-diastolic-dysfunction-and-future-atrial-fibrillation-in-the-tromso-study-from-1994-to-2010 ISSN:1355-6037 https://acuresearchbank.acu.edu.au/download/320162ec392a31d3967f71faf27fd3859d479bfc4d054ada72a2709eb81e4b05/1203834/OA_Tiwari_2015_Association_between_diastolic_dysfunction_and_future.pdf https://doi.org/10.1136/heartjnl-2015-307438 Tiwari, Sweta, Schirmer, Henrik, Jacobsen, Bjarne K., Hopstock, Laila Arnesdatter, Nyrnes, Audhild, Heggelund, Geir, Njolstad, I, Mathiesen, E. B. and Loechen, Maja-Lisa. (2015). Association between diastolic dysfunction and future atrial fibrillation in the Tromso Study from 1994 to 2010. Heart. 101(16), pp. 1302 - 1308. https://doi.org/10.1136/heartjnl-2015-307438 |
op_rights |
CC BY-NC 4.0 |
op_doi |
https://doi.org/10.1136/heartjnl-2015-307438 |
container_title |
Heart |
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101 |
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16 |
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1302 |
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1308 |
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