Migration of Cyclohexanone and 3,3,5-trimethylcyclohexanone from a Neonatal Enteral Feeding System into Human Milk

• Published in: Journal of Perinatology
• Main Authors: Prazad, Preetha, Donovan, Ramona, Won, Brian, Cortes, Donald
• Format: Text
• Language: unknown
• Published: Advocate Aurora Health Institutional Repository 2021
• Subjects: Advocate Aurora Research Institute; Aurora Research Institute
• Online Access: https://institutionalrepository.aah.org/neo/16; https://doi.org/10.1038/s41372-021-01036-3; https://xk8bg6rv9a.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Migration+of+cyclohexanone+and+3,3,5-trimethylcyclohexanone+from+a+neonatal+enteral+feeding+system+into+human+milk&rft.jtitle=Journal+of+perinatology&rft.date=2021-05-01&rft.eissn=1476-5543&rft.volume=41&rft.issue=5&rft.spage=1074&rft.epage=1082&rft_id=info:doi/10.1038%2Fs41372-021-01036-3&rft.externalDBID=NO_FULL_TEXT&paramdict=en-US

OBJECTIVE: Estimate the migration of volatile organic compounds (VOCs) which have been identified by the EPA as a public health concern, from the enteral feeding system into human milk. STUDY DESIGN: Unfortified human milk samples were infused through an enteral feeding system with varying duration of infusion, incubator temperature, and pre-infusion tube priming. Purge & Trap analysis and GC/MS were used to identify the VOC profile of milk pre- and post-infusion. RESULT: Cyclohexanone and 3,3,5-trimethylcyclohexanone (3,3,5-TMC) accumulated significantly in milk samples post-infusion. Duration of infusion had a significant effect on VOC accumulation (p = 0.001). Accumulation patterns of cyclohexanone and 3,3,5-TMC differed significantly based on milk type (donor vs. mother's own milk). CONCLUSIONS: VOCs, migrate from plastic-based feeding equipment into human milk. Based on these findings, limiting the duration of feeding infusion would reduce VOC exposure derived from enteral feeding in the neonatal intensive care unit.