Intermittent neonatal hypoxia elicits the upregulation of inflammatory-related genes in adult male rats through long-lasting programming effects
The long-term effects of neonatal intermittent hypoxia (IH), an accepted model of apnea-induced hypoxia, are unclear. We have previously shown lasting "programming" effects on the HPA axis in adult rats exposed to neonatal IH. We hypothesized that neonatal rat exposure to IH will subsequen...
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ftaurorahc:oai:institutionalrepository.aah.org:endo-1023 2023-07-23T04:18:25+02:00 Intermittent neonatal hypoxia elicits the upregulation of inflammatory-related genes in adult male rats through long-lasting programming effects Gehrand, Ashley Kaldunski, Mary L Bruder, Eric D Jia, Shuang Hessner, Martin J Raff, Hershel 2015-12-01T08:00:00Z https://institutionalrepository.aah.org/endo/23 https://doi.org/10.14814/phy2.12646 unknown Advocate Aurora Health Institutional Repository https://institutionalrepository.aah.org/endo/23 doi:10.14814/phy2.12646 Endocrinology Glucose inflammation insulin intermittent hypoxia neonatal newborn programming Advocate Aurora Research Institute text 2015 ftaurorahc https://doi.org/10.14814/phy2.12646 2023-07-05T20:24:33Z The long-term effects of neonatal intermittent hypoxia (IH), an accepted model of apnea-induced hypoxia, are unclear. We have previously shown lasting "programming" effects on the HPA axis in adult rats exposed to neonatal IH. We hypothesized that neonatal rat exposure to IH will subsequently result in a heightened inflammatory state in the adult. Rat pups were exposed to normoxia (control) or six cycles of 5% IH or 10% IH over one hour daily from postnatal day 2-6. Plasma samples from blood obtained at 114 days of age were analyzed by assessing the capacity to induce transcription in a healthy peripheral blood mononuclear cell (PBMC) population and read using a high-density microarray. The analysis of plasma from adult rats previously exposed to neonatal 5% IH versus 10% IH resulted in 2579 significantly regulated genes including increased expression of Cxcl1, Cxcl2, Ccl3, Il1a, and Il1b. We conclude that neonatal exposure to intermittent hypoxia elicits a long-lasting programming effect in the adult resulting in an upregulation of inflammatory-related genes. Text Aurora Research Institute Aurora Health Care Digital Repository Physiological Reports 3 12 e12646 |
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Aurora Health Care Digital Repository |
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Glucose inflammation insulin intermittent hypoxia neonatal newborn programming Advocate Aurora Research Institute |
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Glucose inflammation insulin intermittent hypoxia neonatal newborn programming Advocate Aurora Research Institute Gehrand, Ashley Kaldunski, Mary L Bruder, Eric D Jia, Shuang Hessner, Martin J Raff, Hershel Intermittent neonatal hypoxia elicits the upregulation of inflammatory-related genes in adult male rats through long-lasting programming effects |
topic_facet |
Glucose inflammation insulin intermittent hypoxia neonatal newborn programming Advocate Aurora Research Institute |
description |
The long-term effects of neonatal intermittent hypoxia (IH), an accepted model of apnea-induced hypoxia, are unclear. We have previously shown lasting "programming" effects on the HPA axis in adult rats exposed to neonatal IH. We hypothesized that neonatal rat exposure to IH will subsequently result in a heightened inflammatory state in the adult. Rat pups were exposed to normoxia (control) or six cycles of 5% IH or 10% IH over one hour daily from postnatal day 2-6. Plasma samples from blood obtained at 114 days of age were analyzed by assessing the capacity to induce transcription in a healthy peripheral blood mononuclear cell (PBMC) population and read using a high-density microarray. The analysis of plasma from adult rats previously exposed to neonatal 5% IH versus 10% IH resulted in 2579 significantly regulated genes including increased expression of Cxcl1, Cxcl2, Ccl3, Il1a, and Il1b. We conclude that neonatal exposure to intermittent hypoxia elicits a long-lasting programming effect in the adult resulting in an upregulation of inflammatory-related genes. |
format |
Text |
author |
Gehrand, Ashley Kaldunski, Mary L Bruder, Eric D Jia, Shuang Hessner, Martin J Raff, Hershel |
author_facet |
Gehrand, Ashley Kaldunski, Mary L Bruder, Eric D Jia, Shuang Hessner, Martin J Raff, Hershel |
author_sort |
Gehrand, Ashley |
title |
Intermittent neonatal hypoxia elicits the upregulation of inflammatory-related genes in adult male rats through long-lasting programming effects |
title_short |
Intermittent neonatal hypoxia elicits the upregulation of inflammatory-related genes in adult male rats through long-lasting programming effects |
title_full |
Intermittent neonatal hypoxia elicits the upregulation of inflammatory-related genes in adult male rats through long-lasting programming effects |
title_fullStr |
Intermittent neonatal hypoxia elicits the upregulation of inflammatory-related genes in adult male rats through long-lasting programming effects |
title_full_unstemmed |
Intermittent neonatal hypoxia elicits the upregulation of inflammatory-related genes in adult male rats through long-lasting programming effects |
title_sort |
intermittent neonatal hypoxia elicits the upregulation of inflammatory-related genes in adult male rats through long-lasting programming effects |
publisher |
Advocate Aurora Health Institutional Repository |
publishDate |
2015 |
url |
https://institutionalrepository.aah.org/endo/23 https://doi.org/10.14814/phy2.12646 |
genre |
Aurora Research Institute |
genre_facet |
Aurora Research Institute |
op_source |
Endocrinology |
op_relation |
https://institutionalrepository.aah.org/endo/23 doi:10.14814/phy2.12646 |
op_doi |
https://doi.org/10.14814/phy2.12646 |
container_title |
Physiological Reports |
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3 |
container_issue |
12 |
container_start_page |
e12646 |
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1772180743359823872 |