Biobehavioral measures as outcomes: a cautionary tale

• Published in: Research in Gerontological Nursing
• Main Authors: Kovach, Christine R, Woods, Diana Lynn, Devine, Elizabeth C, Logan, Brent R, Raff, Hershel
• Format: Text
• Language: unknown
• Published: Advocate Aurora Health Institutional Repository 2014
• Subjects: Aged; 80 and over; Biological Markers; Dementia; Female; Humans; Hydrocortisone; Intervention Studies; Nursing Homes; Observation; Outcome Assessment (Health Care); Pain Management; Pain Measurement; Psychomotor Agitation; Advocate Aurora Research Institute; Aurora Research Institute
• Online Access: https://institutionalrepository.aah.org/behav/5; https://doi.org/10.3928/19404921-20131018-01

This article discusses the use of biobehavioral measures as outcomes for health care intervention studies. Effect size (ES) values for salivary cortisol and observation-based measures of pain and agitation were examined. Effects pre to post treatment were assessed separately for nursing home residents with and without acute psychotic symptoms. This study revealed large positive effects on both pain and agitation measures in the group with acute psychotic symptoms and small-to-medium positive effects on these same measures in the group without acute psychotic symptoms. In both of these groups, the ES values were not consistently positive on the cortisol measures. Prior to determining whether a measure can be used to estimate minimum clinically important differences, it is essential to consider if the biomarker will be responsive to therapy in the populations and contexts being studied.