Sleep restriction during opioid abstinence affects the hypothalamic-pituitary-adrenal (HPA) axis in male and female rats
Hypothalamic-pituitary-adrenal (HPA) axis dynamics are disrupted by opioids and may be involved in substance abuse; this persists during withdrawal and abstinence and is associated with co-morbid sleep disruption leading to vulnerability to relapse. We hypothesized that chronic sleep restriction (SR...
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ftaurorahc:oai:institutionalrepository.aah.org:allother-1464 2023-07-23T04:18:25+02:00 Sleep restriction during opioid abstinence affects the hypothalamic-pituitary-adrenal (HPA) axis in male and female rats Raff, Hershel Glaeser, Breanna L Szabo, Aniko Olsen, Christopher M Everson, Carol A 2023-01-01T08:00:00Z https://institutionalrepository.aah.org/allother/464 https://doi.org/10.1080/10253890.2023.2185864 https://libkey.io/libraries/1712/10.1080/10253890.2023.2185864 unknown Advocate Aurora Health Institutional Repository https://institutionalrepository.aah.org/allother/464 doi:10.1080/10253890.2023.2185864 https://libkey.io/libraries/1712/10.1080/10253890.2023.2185864 All Other Contributions ACTH abstinence corticosterone oxycodone sleep vasopressin Advocate Aurora Research Institute Endocrinology text 2023 ftaurorahc https://doi.org/10.1080/10253890.2023.2185864 2023-07-05T20:22:41Z Hypothalamic-pituitary-adrenal (HPA) axis dynamics are disrupted by opioids and may be involved in substance abuse; this persists during withdrawal and abstinence and is associated with co-morbid sleep disruption leading to vulnerability to relapse. We hypothesized that chronic sleep restriction (SR) alters the HPA axis diurnal rhythm and the sexually dimorphic response to acute stressor during opioid abstinence. We developed a rat model to evaluate the effect of persistent sleep loss during opioid abstinence on HPA axis dynamics in male and female rats. Plasma ACTH and corticosterone were measured diurnally and in response to acute restraint stress in rats Before (control) compared to During subsequent opioid abstinence without or with SR. Abstinence, regardless of sleep state, led to an increase in plasma ACTH and corticosterone in the morning in males. There was a tendency for higher PM plasma ACTH during abstinence in SR males (P = 0.076). ACTH and corticosterone responses to restraint were reduced in male SR rats whereas there was a failure to achieve the post-restraint nadir in female SR rats. There was no effect of the treatments or interventions on adrenal weight normalized to body weight. SR resulted in a dramatic increase in hypothalamic PVN AVP mRNA and plasma copeptin in male but not female rats. This corresponded to the attenuation of the HPA axis stress response in SR males during opioid abstinence. We have identified a potentially unique, sexually dimorphic role for magnocellular vasopressin in the control of the HPA axis during opioid abstinence and sleep restriction. Text Aurora Research Institute Aurora Health Care Digital Repository Stress 26 1 |
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ACTH abstinence corticosterone oxycodone sleep vasopressin Advocate Aurora Research Institute Endocrinology |
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ACTH abstinence corticosterone oxycodone sleep vasopressin Advocate Aurora Research Institute Endocrinology Raff, Hershel Glaeser, Breanna L Szabo, Aniko Olsen, Christopher M Everson, Carol A Sleep restriction during opioid abstinence affects the hypothalamic-pituitary-adrenal (HPA) axis in male and female rats |
topic_facet |
ACTH abstinence corticosterone oxycodone sleep vasopressin Advocate Aurora Research Institute Endocrinology |
description |
Hypothalamic-pituitary-adrenal (HPA) axis dynamics are disrupted by opioids and may be involved in substance abuse; this persists during withdrawal and abstinence and is associated with co-morbid sleep disruption leading to vulnerability to relapse. We hypothesized that chronic sleep restriction (SR) alters the HPA axis diurnal rhythm and the sexually dimorphic response to acute stressor during opioid abstinence. We developed a rat model to evaluate the effect of persistent sleep loss during opioid abstinence on HPA axis dynamics in male and female rats. Plasma ACTH and corticosterone were measured diurnally and in response to acute restraint stress in rats Before (control) compared to During subsequent opioid abstinence without or with SR. Abstinence, regardless of sleep state, led to an increase in plasma ACTH and corticosterone in the morning in males. There was a tendency for higher PM plasma ACTH during abstinence in SR males (P = 0.076). ACTH and corticosterone responses to restraint were reduced in male SR rats whereas there was a failure to achieve the post-restraint nadir in female SR rats. There was no effect of the treatments or interventions on adrenal weight normalized to body weight. SR resulted in a dramatic increase in hypothalamic PVN AVP mRNA and plasma copeptin in male but not female rats. This corresponded to the attenuation of the HPA axis stress response in SR males during opioid abstinence. We have identified a potentially unique, sexually dimorphic role for magnocellular vasopressin in the control of the HPA axis during opioid abstinence and sleep restriction. |
format |
Text |
author |
Raff, Hershel Glaeser, Breanna L Szabo, Aniko Olsen, Christopher M Everson, Carol A |
author_facet |
Raff, Hershel Glaeser, Breanna L Szabo, Aniko Olsen, Christopher M Everson, Carol A |
author_sort |
Raff, Hershel |
title |
Sleep restriction during opioid abstinence affects the hypothalamic-pituitary-adrenal (HPA) axis in male and female rats |
title_short |
Sleep restriction during opioid abstinence affects the hypothalamic-pituitary-adrenal (HPA) axis in male and female rats |
title_full |
Sleep restriction during opioid abstinence affects the hypothalamic-pituitary-adrenal (HPA) axis in male and female rats |
title_fullStr |
Sleep restriction during opioid abstinence affects the hypothalamic-pituitary-adrenal (HPA) axis in male and female rats |
title_full_unstemmed |
Sleep restriction during opioid abstinence affects the hypothalamic-pituitary-adrenal (HPA) axis in male and female rats |
title_sort |
sleep restriction during opioid abstinence affects the hypothalamic-pituitary-adrenal (hpa) axis in male and female rats |
publisher |
Advocate Aurora Health Institutional Repository |
publishDate |
2023 |
url |
https://institutionalrepository.aah.org/allother/464 https://doi.org/10.1080/10253890.2023.2185864 https://libkey.io/libraries/1712/10.1080/10253890.2023.2185864 |
genre |
Aurora Research Institute |
genre_facet |
Aurora Research Institute |
op_source |
All Other Contributions |
op_relation |
https://institutionalrepository.aah.org/allother/464 doi:10.1080/10253890.2023.2185864 https://libkey.io/libraries/1712/10.1080/10253890.2023.2185864 |
op_doi |
https://doi.org/10.1080/10253890.2023.2185864 |
container_title |
Stress |
container_volume |
26 |
container_issue |
1 |
_version_ |
1772180748519866368 |