Association of the triglyceride glucose index as a measure of insulin resistance with mortality and cardiovascular disease in populations from five continents (PURE study): A prospective cohort study
Background: The triglyceride glucose (TyG) index is an easily accessible surrogate marker of insulin resistance, an important pathway in the development of type 2 diabetes and cardiovascular diseases. However, the association of the TyG index with cardiovascular diseases and mortality has mainly bee...
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ftaurorahc:oai:institutionalrepository.aah.org:allother-1402 2023-07-23T04:18:26+02:00 Association of the triglyceride glucose index as a measure of insulin resistance with mortality and cardiovascular disease in populations from five continents (PURE study): A prospective cohort study Lopez-Jaramillo, Patricio Gomez-Arbelaez, Diego Martinez-Bello, Daniel Abat, Marc Evans Alhabib, Khalid F Avezum, Álvaro Barbarash, Olga Chifamba, Jephat Diaz, Maria L Gulec, Sadi Ismail, Noorhassim Iqbal, Romaina Kelishadi, Roya Khatib, Rasha Lanas, Fernando Levitt, Naomi S Li, Yang Mohan, Viswanathan Mony, Prem K Poirier, Paul Rosengren, Annika Soman, Biju Wang, Chuangshi Wang, Yang Yeates, Karen Yusuf, Rita Yusufali, Afzalhussein Zatonska, Katarzyna Rangarajan, Sumathy Yusuf, Salim 2023-01-01T08:00:00Z https://institutionalrepository.aah.org/allother/402 https://doi.org/10.1016/S2666-7568(22)00247-1 https://libkey.io/libraries/1712/10.1016/S2666-7568(22)00247-1 unknown Advocate Aurora Health Institutional Repository https://institutionalrepository.aah.org/allother/402 doi:10.1016/S2666-7568(22)00247-1 https://libkey.io/libraries/1712/10.1016/S2666-7568(22)00247-1 All Other Contributions insulin triglycerides cardiovascular disease population health Advocate Aurora Research Institute Cardiology Population Health and Public Health text 2023 ftaurorahc https://doi.org/10.1016/S2666-7568(22)00247-1 2023-07-05T20:21:56Z Background: The triglyceride glucose (TyG) index is an easily accessible surrogate marker of insulin resistance, an important pathway in the development of type 2 diabetes and cardiovascular diseases. However, the association of the TyG index with cardiovascular diseases and mortality has mainly been investigated in Asia, with few data available from other regions of the world. We assessed the association of insulin resistance (as determined by the TyG index) with mortality and cardiovascular diseases in individuals from five continents at different levels of economic development, living in urban or rural areas. We also examined whether the associations differed according to the country's economical development. Methods: We used the TyG index as a surrogate measure for insulin resistance. Fasting triglycerides and fasting plasma glucose were measured at the baseline visit in 141 243 individuals aged 35-70 years from 22 countries in the Prospective Urban Rural Epidemiology (PURE) study. The TyG index was calculated as Ln (fasting triglycerides [mg/dL] x fasting plasma glucose [mg/dL]/2). We calculated hazard ratios (HRs) using a multivariable Cox frailty model with random effects to test the associations between the TyG index and risk of cardiovascular diseases and mortality. The primary outcome of this analysis was the composite of mortality or major cardiovascular events (defined as death from cardiovascular causes, and non-fatal myocardial infarction, or stroke). Secondary outcomes were non-cardiovascular mortality, cardiovascular mortality, all myocardial infarctions, stroke, and incident diabetes. We also did subgroup analyses to examine the magnitude of associations between insulin resistance (ie, the TyG index) and outcome events according to the income level of the countries. Findings: During a median follow-up of 13·2 years (IQR 11·9-14·6), we recorded 6345 composite cardiovascular diseases events, 2030 cardiovascular deaths, 3038 cases of myocardial infarction, 3291 cases of stroke, and 5191 incident ... Text Aurora Research Institute Aurora Health Care Digital Repository The Lancet Healthy Longevity 4 1 e23 e33 |
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insulin triglycerides cardiovascular disease population health Advocate Aurora Research Institute Cardiology Population Health and Public Health |
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insulin triglycerides cardiovascular disease population health Advocate Aurora Research Institute Cardiology Population Health and Public Health Lopez-Jaramillo, Patricio Gomez-Arbelaez, Diego Martinez-Bello, Daniel Abat, Marc Evans Alhabib, Khalid F Avezum, Álvaro Barbarash, Olga Chifamba, Jephat Diaz, Maria L Gulec, Sadi Ismail, Noorhassim Iqbal, Romaina Kelishadi, Roya Khatib, Rasha Lanas, Fernando Levitt, Naomi S Li, Yang Mohan, Viswanathan Mony, Prem K Poirier, Paul Rosengren, Annika Soman, Biju Wang, Chuangshi Wang, Yang Yeates, Karen Yusuf, Rita Yusufali, Afzalhussein Zatonska, Katarzyna Rangarajan, Sumathy Yusuf, Salim Association of the triglyceride glucose index as a measure of insulin resistance with mortality and cardiovascular disease in populations from five continents (PURE study): A prospective cohort study |
topic_facet |
insulin triglycerides cardiovascular disease population health Advocate Aurora Research Institute Cardiology Population Health and Public Health |
description |
Background: The triglyceride glucose (TyG) index is an easily accessible surrogate marker of insulin resistance, an important pathway in the development of type 2 diabetes and cardiovascular diseases. However, the association of the TyG index with cardiovascular diseases and mortality has mainly been investigated in Asia, with few data available from other regions of the world. We assessed the association of insulin resistance (as determined by the TyG index) with mortality and cardiovascular diseases in individuals from five continents at different levels of economic development, living in urban or rural areas. We also examined whether the associations differed according to the country's economical development. Methods: We used the TyG index as a surrogate measure for insulin resistance. Fasting triglycerides and fasting plasma glucose were measured at the baseline visit in 141 243 individuals aged 35-70 years from 22 countries in the Prospective Urban Rural Epidemiology (PURE) study. The TyG index was calculated as Ln (fasting triglycerides [mg/dL] x fasting plasma glucose [mg/dL]/2). We calculated hazard ratios (HRs) using a multivariable Cox frailty model with random effects to test the associations between the TyG index and risk of cardiovascular diseases and mortality. The primary outcome of this analysis was the composite of mortality or major cardiovascular events (defined as death from cardiovascular causes, and non-fatal myocardial infarction, or stroke). Secondary outcomes were non-cardiovascular mortality, cardiovascular mortality, all myocardial infarctions, stroke, and incident diabetes. We also did subgroup analyses to examine the magnitude of associations between insulin resistance (ie, the TyG index) and outcome events according to the income level of the countries. Findings: During a median follow-up of 13·2 years (IQR 11·9-14·6), we recorded 6345 composite cardiovascular diseases events, 2030 cardiovascular deaths, 3038 cases of myocardial infarction, 3291 cases of stroke, and 5191 incident ... |
format |
Text |
author |
Lopez-Jaramillo, Patricio Gomez-Arbelaez, Diego Martinez-Bello, Daniel Abat, Marc Evans Alhabib, Khalid F Avezum, Álvaro Barbarash, Olga Chifamba, Jephat Diaz, Maria L Gulec, Sadi Ismail, Noorhassim Iqbal, Romaina Kelishadi, Roya Khatib, Rasha Lanas, Fernando Levitt, Naomi S Li, Yang Mohan, Viswanathan Mony, Prem K Poirier, Paul Rosengren, Annika Soman, Biju Wang, Chuangshi Wang, Yang Yeates, Karen Yusuf, Rita Yusufali, Afzalhussein Zatonska, Katarzyna Rangarajan, Sumathy Yusuf, Salim |
author_facet |
Lopez-Jaramillo, Patricio Gomez-Arbelaez, Diego Martinez-Bello, Daniel Abat, Marc Evans Alhabib, Khalid F Avezum, Álvaro Barbarash, Olga Chifamba, Jephat Diaz, Maria L Gulec, Sadi Ismail, Noorhassim Iqbal, Romaina Kelishadi, Roya Khatib, Rasha Lanas, Fernando Levitt, Naomi S Li, Yang Mohan, Viswanathan Mony, Prem K Poirier, Paul Rosengren, Annika Soman, Biju Wang, Chuangshi Wang, Yang Yeates, Karen Yusuf, Rita Yusufali, Afzalhussein Zatonska, Katarzyna Rangarajan, Sumathy Yusuf, Salim |
author_sort |
Lopez-Jaramillo, Patricio |
title |
Association of the triglyceride glucose index as a measure of insulin resistance with mortality and cardiovascular disease in populations from five continents (PURE study): A prospective cohort study |
title_short |
Association of the triglyceride glucose index as a measure of insulin resistance with mortality and cardiovascular disease in populations from five continents (PURE study): A prospective cohort study |
title_full |
Association of the triglyceride glucose index as a measure of insulin resistance with mortality and cardiovascular disease in populations from five continents (PURE study): A prospective cohort study |
title_fullStr |
Association of the triglyceride glucose index as a measure of insulin resistance with mortality and cardiovascular disease in populations from five continents (PURE study): A prospective cohort study |
title_full_unstemmed |
Association of the triglyceride glucose index as a measure of insulin resistance with mortality and cardiovascular disease in populations from five continents (PURE study): A prospective cohort study |
title_sort |
association of the triglyceride glucose index as a measure of insulin resistance with mortality and cardiovascular disease in populations from five continents (pure study): a prospective cohort study |
publisher |
Advocate Aurora Health Institutional Repository |
publishDate |
2023 |
url |
https://institutionalrepository.aah.org/allother/402 https://doi.org/10.1016/S2666-7568(22)00247-1 https://libkey.io/libraries/1712/10.1016/S2666-7568(22)00247-1 |
genre |
Aurora Research Institute |
genre_facet |
Aurora Research Institute |
op_source |
All Other Contributions |
op_relation |
https://institutionalrepository.aah.org/allother/402 doi:10.1016/S2666-7568(22)00247-1 https://libkey.io/libraries/1712/10.1016/S2666-7568(22)00247-1 |
op_doi |
https://doi.org/10.1016/S2666-7568(22)00247-1 |
container_title |
The Lancet Healthy Longevity |
container_volume |
4 |
container_issue |
1 |
container_start_page |
e23 |
op_container_end_page |
e33 |
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1772180757672886272 |