Association of sitting time with mortality and cardiovascular events in high-income, middle-income, and low-income countries
Importance: High amounts of sitting time are associated with increased risks of cardiovascular disease (CVD) and mortality in high-income countries, but it is unknown whether risks also increase in low- and middle-income countries. Objective: To investigate the association of sitting time with morta...
Published in: | JAMA Cardiology |
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2022
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Online Access: | https://institutionalrepository.aah.org/allother/254 https://doi.org/10.1001/jamacardio.2022.1581 https://libkey.io/libraries/1712/pmid/35704349 |
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ftaurorahc:oai:institutionalrepository.aah.org:allother-1253 2023-07-23T04:18:26+02:00 Association of sitting time with mortality and cardiovascular events in high-income, middle-income, and low-income countries Li, Sidong Lear, Scott A Rangarajan, Sumathy Hu, Bo Yin, Lu Bangdiwala, Shrikant I Alhabib, Khalid F Rosengren, Annika Gupta, Rajeev Mony, Prem K Wielgosz, Andreas Rahman, Omar Mazapuspavina, M Y Avezum, Alvaro Oguz, Aytekin Yeates, Karen Lanas, Fernando Dans, Antonio Abat, Marc Evans Yusufali, Afzalhussein Diaz, Rafael Lopez-Jaramillo, Patricio Leach, Lloyd Lakshmi, P V Basiak-Rasala, Alicja Iqbal, Romaina Kelishadi, Roya Chifamba, Jephat Khatib, Rasha Li, Wei Yusuf, Salim 2022-08-01T07:00:00Z https://institutionalrepository.aah.org/allother/254 https://doi.org/10.1001/jamacardio.2022.1581 https://libkey.io/libraries/1712/pmid/35704349 unknown Advocate Aurora Health Institutional Repository https://institutionalrepository.aah.org/allother/254 doi:10.1001/jamacardio.2022.1581 https://libkey.io/libraries/1712/pmid/35704349 All Other Contributions Advocate Aurora Research Institute Population Health and Public Health text 2022 ftaurorahc https://doi.org/10.1001/jamacardio.2022.1581 2023-07-05T20:21:18Z Importance: High amounts of sitting time are associated with increased risks of cardiovascular disease (CVD) and mortality in high-income countries, but it is unknown whether risks also increase in low- and middle-income countries. Objective: To investigate the association of sitting time with mortality and major CVD in countries at different economic levels using data from the Prospective Urban Rural Epidemiology study. Design, setting, and participants: This population-based cohort study included participants aged 35 to 70 years recruited from January 1, 2003, and followed up until August 31, 2021, in 21 high-income, middle-income, and low-income countries with a median follow-up of 11.1 years. Exposures: Daily sitting time measured using the International Physical Activity Questionnaire. Main outcomes and measures: The composite of all-cause mortality and major CVD (defined as cardiovascular death, myocardial infarction, stroke, or heart failure). Results: Of 105 677 participants, 61 925 (58.6%) were women, and the mean (SD) age was 50.4 (9.6) years. During a median follow-up of 11.1 (IQR, 8.6-12.2) years, 6233 deaths and 5696 major cardiovascular events (2349 myocardial infarctions, 2966 strokes, 671 heart failure, and 1792 cardiovascular deaths) were documented. Compared with the reference group (sitting), higher sitting time (≥8 hours per day) was associated with an increased risk of the composite outcome (hazard ratio [HR], 1.19; 95% CI, 1.11-1.28; Pfor trend < .001), all-cause mortality (HR, 1.20; 95% CI, 1.10-1.31; Pfor trend < .001), and major CVD (HR, 1.21; 95% CI, 1.10-1.34; Pfor trend < .001). When stratified by country income levels, the association of sitting time with the composite outcome was stronger in low-income and lower-middle-income countries (≥8 hours per day: HR, 1.29; 95% CI, 1.16-1.44) compared with high-income and upper-middle-income countries (HR, 1.08; 95% CI, 0.98-1.19; P for interaction = .02). Compared with those who reported sitting time less than 4 hours per day and ... Text Aurora Research Institute Aurora Health Care Digital Repository JAMA Cardiology 7 8 796 |
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Aurora Health Care Digital Repository |
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Advocate Aurora Research Institute Population Health and Public Health |
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Advocate Aurora Research Institute Population Health and Public Health Li, Sidong Lear, Scott A Rangarajan, Sumathy Hu, Bo Yin, Lu Bangdiwala, Shrikant I Alhabib, Khalid F Rosengren, Annika Gupta, Rajeev Mony, Prem K Wielgosz, Andreas Rahman, Omar Mazapuspavina, M Y Avezum, Alvaro Oguz, Aytekin Yeates, Karen Lanas, Fernando Dans, Antonio Abat, Marc Evans Yusufali, Afzalhussein Diaz, Rafael Lopez-Jaramillo, Patricio Leach, Lloyd Lakshmi, P V Basiak-Rasala, Alicja Iqbal, Romaina Kelishadi, Roya Chifamba, Jephat Khatib, Rasha Li, Wei Yusuf, Salim Association of sitting time with mortality and cardiovascular events in high-income, middle-income, and low-income countries |
topic_facet |
Advocate Aurora Research Institute Population Health and Public Health |
description |
Importance: High amounts of sitting time are associated with increased risks of cardiovascular disease (CVD) and mortality in high-income countries, but it is unknown whether risks also increase in low- and middle-income countries. Objective: To investigate the association of sitting time with mortality and major CVD in countries at different economic levels using data from the Prospective Urban Rural Epidemiology study. Design, setting, and participants: This population-based cohort study included participants aged 35 to 70 years recruited from January 1, 2003, and followed up until August 31, 2021, in 21 high-income, middle-income, and low-income countries with a median follow-up of 11.1 years. Exposures: Daily sitting time measured using the International Physical Activity Questionnaire. Main outcomes and measures: The composite of all-cause mortality and major CVD (defined as cardiovascular death, myocardial infarction, stroke, or heart failure). Results: Of 105 677 participants, 61 925 (58.6%) were women, and the mean (SD) age was 50.4 (9.6) years. During a median follow-up of 11.1 (IQR, 8.6-12.2) years, 6233 deaths and 5696 major cardiovascular events (2349 myocardial infarctions, 2966 strokes, 671 heart failure, and 1792 cardiovascular deaths) were documented. Compared with the reference group (sitting), higher sitting time (≥8 hours per day) was associated with an increased risk of the composite outcome (hazard ratio [HR], 1.19; 95% CI, 1.11-1.28; Pfor trend < .001), all-cause mortality (HR, 1.20; 95% CI, 1.10-1.31; Pfor trend < .001), and major CVD (HR, 1.21; 95% CI, 1.10-1.34; Pfor trend < .001). When stratified by country income levels, the association of sitting time with the composite outcome was stronger in low-income and lower-middle-income countries (≥8 hours per day: HR, 1.29; 95% CI, 1.16-1.44) compared with high-income and upper-middle-income countries (HR, 1.08; 95% CI, 0.98-1.19; P for interaction = .02). Compared with those who reported sitting time less than 4 hours per day and ... |
format |
Text |
author |
Li, Sidong Lear, Scott A Rangarajan, Sumathy Hu, Bo Yin, Lu Bangdiwala, Shrikant I Alhabib, Khalid F Rosengren, Annika Gupta, Rajeev Mony, Prem K Wielgosz, Andreas Rahman, Omar Mazapuspavina, M Y Avezum, Alvaro Oguz, Aytekin Yeates, Karen Lanas, Fernando Dans, Antonio Abat, Marc Evans Yusufali, Afzalhussein Diaz, Rafael Lopez-Jaramillo, Patricio Leach, Lloyd Lakshmi, P V Basiak-Rasala, Alicja Iqbal, Romaina Kelishadi, Roya Chifamba, Jephat Khatib, Rasha Li, Wei Yusuf, Salim |
author_facet |
Li, Sidong Lear, Scott A Rangarajan, Sumathy Hu, Bo Yin, Lu Bangdiwala, Shrikant I Alhabib, Khalid F Rosengren, Annika Gupta, Rajeev Mony, Prem K Wielgosz, Andreas Rahman, Omar Mazapuspavina, M Y Avezum, Alvaro Oguz, Aytekin Yeates, Karen Lanas, Fernando Dans, Antonio Abat, Marc Evans Yusufali, Afzalhussein Diaz, Rafael Lopez-Jaramillo, Patricio Leach, Lloyd Lakshmi, P V Basiak-Rasala, Alicja Iqbal, Romaina Kelishadi, Roya Chifamba, Jephat Khatib, Rasha Li, Wei Yusuf, Salim |
author_sort |
Li, Sidong |
title |
Association of sitting time with mortality and cardiovascular events in high-income, middle-income, and low-income countries |
title_short |
Association of sitting time with mortality and cardiovascular events in high-income, middle-income, and low-income countries |
title_full |
Association of sitting time with mortality and cardiovascular events in high-income, middle-income, and low-income countries |
title_fullStr |
Association of sitting time with mortality and cardiovascular events in high-income, middle-income, and low-income countries |
title_full_unstemmed |
Association of sitting time with mortality and cardiovascular events in high-income, middle-income, and low-income countries |
title_sort |
association of sitting time with mortality and cardiovascular events in high-income, middle-income, and low-income countries |
publisher |
Advocate Aurora Health Institutional Repository |
publishDate |
2022 |
url |
https://institutionalrepository.aah.org/allother/254 https://doi.org/10.1001/jamacardio.2022.1581 https://libkey.io/libraries/1712/pmid/35704349 |
genre |
Aurora Research Institute |
genre_facet |
Aurora Research Institute |
op_source |
All Other Contributions |
op_relation |
https://institutionalrepository.aah.org/allother/254 doi:10.1001/jamacardio.2022.1581 https://libkey.io/libraries/1712/pmid/35704349 |
op_doi |
https://doi.org/10.1001/jamacardio.2022.1581 |
container_title |
JAMA Cardiology |
container_volume |
7 |
container_issue |
8 |
container_start_page |
796 |
_version_ |
1772180757352022016 |