Improvement of glycemic control in streptozotocin-induced diabetic rats by atlantic salmon skin gelatin hydrolysate as the dipeptidyl-peptidase IV inhibitor
In our previous study, Atlantic salmon skin gelatin hydrolysed with flavourzyme possessed 42.5% DPP-IV inhibitory activity at the concentration of 5 mg/mL. The oral administration of hydrolysate (FSGH) at single dose of 300 mg/d in streptozotocin (STZ)-induced diabetic rats for 5 weeks was evaluated...
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| Format: | Article in Journal/Newspaper |
| Language: | Chinese |
| Published: |
2015
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| Online Access: | http://asiair.asia.edu.tw/ir/handle/310904400/91984 http://asiair.asia.edu.tw/ir/bitstream/310904400/91984/2/index.html |
| Summary: | In our previous study, Atlantic salmon skin gelatin hydrolysed with flavourzyme possessed 42.5% DPP-IV inhibitory activity at the concentration of 5 mg/mL. The oral administration of hydrolysate (FSGH) at single dose of 300 mg/d in streptozotocin (STZ)-induced diabetic rats for 5 weeks was evaluated for its antidiabetic effect. During the 5-week experiment, body weight was increased, food and water intake were reduced by FSGH in diabetic rats. The daily administration of FSGH for 5 weeks was effective to lower the blood glucose levels of diabetic rats during oral glucose tolerance test (OGTT). After 5-week treatment, plasma dipeptidyl peptidase (DPP)-IV activity was inhibited; plasma active glucagon-like peptide-1 (GLP-1), insulin and insulin-to-glucagon ratio were increased by FSGH in diabetic rats. The results indicate that FSGH has the function of inhibiting GLP-1 degradation by DPP-IV, resulting in the enhancement of insulin secretion and improvement of glycemic control in STZ-induced diabetic rats. |
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