Cross-talk and mutual shaping between the immune system and the microbiota during an oyster's life
The Pacific oyster Crassostrea gigas lives in microbe-rich marine coastal systems subjected to rapid environmental changes. It harbours a diversified and fluctuating microbiota that cohabits with immune cells expressing a diversified immune gene repertoire. In the early stages of oyster development,...
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ftarchimer:oai:archimer.ifremer.fr:99477 2024-05-12T08:02:45+00:00 Cross-talk and mutual shaping between the immune system and the microbiota during an oyster's life Destoumieux Garzon, Delphine Montagnani, Caroline Dantan, Luc De San Nicolas, Noémie Travers, Agnes Duperret, Léo Charrière, Guillaume M. Toulza, Eve Mitta, Guillaume Cosseau, Céline Escoubas, Jean-michel 2024-05 application/pdf https://archimer.ifremer.fr/doc/00883/99477/109536.pdf https://doi.org/10.1098/rstb.2023.0065 https://archimer.ifremer.fr/doc/00883/99477/ eng eng The Royal Society https://archimer.ifremer.fr/doc/00883/99477/109536.pdf doi:10.1098/rstb.2023.0065 https://archimer.ifremer.fr/doc/00883/99477/ info:eu-repo/semantics/openAccess restricted use Philosophical Transactions Of The Royal Society B-biological Sciences (0962-8436) (The Royal Society), 2024-05 , Vol. 379 , N. 1901 , P. 20230065 (12p.) holobiont microbiome immunity homeostasis immune priming ontogeny text Article info:eu-repo/semantics/article 2024 ftarchimer https://doi.org/10.1098/rstb.2023.0065 2024-04-17T14:00:53Z The Pacific oyster Crassostrea gigas lives in microbe-rich marine coastal systems subjected to rapid environmental changes. It harbours a diversified and fluctuating microbiota that cohabits with immune cells expressing a diversified immune gene repertoire. In the early stages of oyster development, just after fertilization, the microbiota plays a key role in educating the immune system. Exposure to a rich microbial environment at the larval stage leads to an increase in immune competence throughout the life of the oyster, conferring a better protection against pathogenic infections at later juvenile/adult stages. This beneficial effect, which is intergenerational, is associated with epigenetic remodelling. At juvenile stages, the educated immune system participates in the control of the homeostasis. In particular, the microbiota is fine-tuned by oyster antimicrobial peptides acting through specific and synergistic effects. However, this balance is fragile, as illustrated by the Pacific Oyster Mortality Syndrome, a disease causing mass mortalities in oysters worldwide. In this disease, the weakening of oyster immune defences by OsHV-1 µVar virus induces a dysbiosis leading to fatal sepsis. This review illustrates the continuous interaction between the highly diversified oyster immune system and its dynamic microbiota throughout its life, and the importance of this cross-talk for oyster health. This article is part of the theme issue ‘Sculpting the microbiome: how host factors determine and respond to microbial colonization’. Article in Journal/Newspaper Crassostrea gigas Pacific oyster Archimer (Archive Institutionnelle de l'Ifremer - Institut français de recherche pour l'exploitation de la mer) Pacific Philosophical Transactions of the Royal Society B: Biological Sciences 379 1901 |
institution |
Open Polar |
collection |
Archimer (Archive Institutionnelle de l'Ifremer - Institut français de recherche pour l'exploitation de la mer) |
op_collection_id |
ftarchimer |
language |
English |
topic |
holobiont microbiome immunity homeostasis immune priming ontogeny |
spellingShingle |
holobiont microbiome immunity homeostasis immune priming ontogeny Destoumieux Garzon, Delphine Montagnani, Caroline Dantan, Luc De San Nicolas, Noémie Travers, Agnes Duperret, Léo Charrière, Guillaume M. Toulza, Eve Mitta, Guillaume Cosseau, Céline Escoubas, Jean-michel Cross-talk and mutual shaping between the immune system and the microbiota during an oyster's life |
topic_facet |
holobiont microbiome immunity homeostasis immune priming ontogeny |
description |
The Pacific oyster Crassostrea gigas lives in microbe-rich marine coastal systems subjected to rapid environmental changes. It harbours a diversified and fluctuating microbiota that cohabits with immune cells expressing a diversified immune gene repertoire. In the early stages of oyster development, just after fertilization, the microbiota plays a key role in educating the immune system. Exposure to a rich microbial environment at the larval stage leads to an increase in immune competence throughout the life of the oyster, conferring a better protection against pathogenic infections at later juvenile/adult stages. This beneficial effect, which is intergenerational, is associated with epigenetic remodelling. At juvenile stages, the educated immune system participates in the control of the homeostasis. In particular, the microbiota is fine-tuned by oyster antimicrobial peptides acting through specific and synergistic effects. However, this balance is fragile, as illustrated by the Pacific Oyster Mortality Syndrome, a disease causing mass mortalities in oysters worldwide. In this disease, the weakening of oyster immune defences by OsHV-1 µVar virus induces a dysbiosis leading to fatal sepsis. This review illustrates the continuous interaction between the highly diversified oyster immune system and its dynamic microbiota throughout its life, and the importance of this cross-talk for oyster health. This article is part of the theme issue ‘Sculpting the microbiome: how host factors determine and respond to microbial colonization’. |
format |
Article in Journal/Newspaper |
author |
Destoumieux Garzon, Delphine Montagnani, Caroline Dantan, Luc De San Nicolas, Noémie Travers, Agnes Duperret, Léo Charrière, Guillaume M. Toulza, Eve Mitta, Guillaume Cosseau, Céline Escoubas, Jean-michel |
author_facet |
Destoumieux Garzon, Delphine Montagnani, Caroline Dantan, Luc De San Nicolas, Noémie Travers, Agnes Duperret, Léo Charrière, Guillaume M. Toulza, Eve Mitta, Guillaume Cosseau, Céline Escoubas, Jean-michel |
author_sort |
Destoumieux Garzon, Delphine |
title |
Cross-talk and mutual shaping between the immune system and the microbiota during an oyster's life |
title_short |
Cross-talk and mutual shaping between the immune system and the microbiota during an oyster's life |
title_full |
Cross-talk and mutual shaping between the immune system and the microbiota during an oyster's life |
title_fullStr |
Cross-talk and mutual shaping between the immune system and the microbiota during an oyster's life |
title_full_unstemmed |
Cross-talk and mutual shaping between the immune system and the microbiota during an oyster's life |
title_sort |
cross-talk and mutual shaping between the immune system and the microbiota during an oyster's life |
publisher |
The Royal Society |
publishDate |
2024 |
url |
https://archimer.ifremer.fr/doc/00883/99477/109536.pdf https://doi.org/10.1098/rstb.2023.0065 https://archimer.ifremer.fr/doc/00883/99477/ |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
Philosophical Transactions Of The Royal Society B-biological Sciences (0962-8436) (The Royal Society), 2024-05 , Vol. 379 , N. 1901 , P. 20230065 (12p.) |
op_relation |
https://archimer.ifremer.fr/doc/00883/99477/109536.pdf doi:10.1098/rstb.2023.0065 https://archimer.ifremer.fr/doc/00883/99477/ |
op_rights |
info:eu-repo/semantics/openAccess restricted use |
op_doi |
https://doi.org/10.1098/rstb.2023.0065 |
container_title |
Philosophical Transactions of the Royal Society B: Biological Sciences |
container_volume |
379 |
container_issue |
1901 |
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1798844899394584576 |