Epigenetic then genetic variations underpin rapid adaptation of oyster populations (Crassostrea gigas) to Pacific Oyster Mortality Syndrome (POMS)
Disease emergence is accelerating in response to human activity-induced global changes. Understanding the mechanisms by which host populations can rapidly adapt to this threat will be crucial for developing future management practices. Pacific Oyster Mortality Syndrome (POMS) imposes a substantial a...
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Cold Spring Harbor Laboratory
2023
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ftarchimer:oai:archimer.ifremer.fr:93938 2023-05-15T15:58:02+02:00 Epigenetic then genetic variations underpin rapid adaptation of oyster populations (Crassostrea gigas) to Pacific Oyster Mortality Syndrome (POMS) Gawra, Janan Valdivieso, Alejandro Roux, Fabrice Laporte, Martin De Lorgeril, Julien Gueguen, Yannick Saccas, Mathilde Escoubas, Jean-michel Montagnani, Caroline Destoumieux-garzón, Delphine Lagarde, Franck Leroy, Marc A. Haffner, Philippe Petton, Bruno Cosseau, Céline Morga, Benjamin Dégremont, Lionel Mitta, Guillaume Grunau, Christoph Vidal-dupiol, Jeremie 2023-03-12 application/pdf https://archimer.ifremer.fr/doc/00827/93938/100727.pdf https://doi.org/10.1101/2023.03.09.531494 https://archimer.ifremer.fr/doc/00827/93938/ eng eng Cold Spring Harbor Laboratory https://archimer.ifremer.fr/doc/00827/93938/100727.pdf doi:10.1101/2023.03.09.531494 https://archimer.ifremer.fr/doc/00827/93938/ info:eu-repo/semantics/openAccess restricted use BioRxiv (Cold Spring Harbor Laboratory) In Press rapid adaptation genetic epigenetic POMS oyster exome capture text Publication info:eu-repo/semantics/article 2023 ftarchimer https://doi.org/10.1101/2023.03.09.531494 2023-03-21T23:52:14Z Disease emergence is accelerating in response to human activity-induced global changes. Understanding the mechanisms by which host populations can rapidly adapt to this threat will be crucial for developing future management practices. Pacific Oyster Mortality Syndrome (POMS) imposes a substantial and recurrent selective pressure on oyster populations (Crassostrea gigas). Rapid adaptation to this disease may arise through both genetic and epigenetic mechanisms. In this study, we used a combination of whole exome capture of bisulfite-converted DNA, next-generation sequencing, and (epi)genome-wide association mapping, to show that natural oyster populations differentially exposed to POMS displayed signatures of selection both in their genome (single nucleotide polymorphisms) and epigenome (CG-context DNA methylation). Consistent with higher resistance to POMS, the genes targeted by genetic and epigenetic variations were mainly related to host immunity. By combining correlation analyses, DNA methylation quantitative trait loci, and variance partitioning, we revealed that a third of the observed phenotypic variation was explained by interactions between the genetic sequence and epigenetic information, ∼14% by the genetic sequence, and up to 25% by the epigenome alone. Thus, as well as genetic adaptation, epigenetic mechanisms governing immune responses contribute significantly to the rapid adaptation of hosts to emerging infectious diseases. Article in Journal/Newspaper Crassostrea gigas Pacific oyster Archimer (Archive Institutionnelle de l'Ifremer - Institut français de recherche pour l'exploitation de la mer) Pacific |
institution |
Open Polar |
collection |
Archimer (Archive Institutionnelle de l'Ifremer - Institut français de recherche pour l'exploitation de la mer) |
op_collection_id |
ftarchimer |
language |
English |
topic |
rapid adaptation genetic epigenetic POMS oyster exome capture |
spellingShingle |
rapid adaptation genetic epigenetic POMS oyster exome capture Gawra, Janan Valdivieso, Alejandro Roux, Fabrice Laporte, Martin De Lorgeril, Julien Gueguen, Yannick Saccas, Mathilde Escoubas, Jean-michel Montagnani, Caroline Destoumieux-garzón, Delphine Lagarde, Franck Leroy, Marc A. Haffner, Philippe Petton, Bruno Cosseau, Céline Morga, Benjamin Dégremont, Lionel Mitta, Guillaume Grunau, Christoph Vidal-dupiol, Jeremie Epigenetic then genetic variations underpin rapid adaptation of oyster populations (Crassostrea gigas) to Pacific Oyster Mortality Syndrome (POMS) |
topic_facet |
rapid adaptation genetic epigenetic POMS oyster exome capture |
description |
Disease emergence is accelerating in response to human activity-induced global changes. Understanding the mechanisms by which host populations can rapidly adapt to this threat will be crucial for developing future management practices. Pacific Oyster Mortality Syndrome (POMS) imposes a substantial and recurrent selective pressure on oyster populations (Crassostrea gigas). Rapid adaptation to this disease may arise through both genetic and epigenetic mechanisms. In this study, we used a combination of whole exome capture of bisulfite-converted DNA, next-generation sequencing, and (epi)genome-wide association mapping, to show that natural oyster populations differentially exposed to POMS displayed signatures of selection both in their genome (single nucleotide polymorphisms) and epigenome (CG-context DNA methylation). Consistent with higher resistance to POMS, the genes targeted by genetic and epigenetic variations were mainly related to host immunity. By combining correlation analyses, DNA methylation quantitative trait loci, and variance partitioning, we revealed that a third of the observed phenotypic variation was explained by interactions between the genetic sequence and epigenetic information, ∼14% by the genetic sequence, and up to 25% by the epigenome alone. Thus, as well as genetic adaptation, epigenetic mechanisms governing immune responses contribute significantly to the rapid adaptation of hosts to emerging infectious diseases. |
format |
Article in Journal/Newspaper |
author |
Gawra, Janan Valdivieso, Alejandro Roux, Fabrice Laporte, Martin De Lorgeril, Julien Gueguen, Yannick Saccas, Mathilde Escoubas, Jean-michel Montagnani, Caroline Destoumieux-garzón, Delphine Lagarde, Franck Leroy, Marc A. Haffner, Philippe Petton, Bruno Cosseau, Céline Morga, Benjamin Dégremont, Lionel Mitta, Guillaume Grunau, Christoph Vidal-dupiol, Jeremie |
author_facet |
Gawra, Janan Valdivieso, Alejandro Roux, Fabrice Laporte, Martin De Lorgeril, Julien Gueguen, Yannick Saccas, Mathilde Escoubas, Jean-michel Montagnani, Caroline Destoumieux-garzón, Delphine Lagarde, Franck Leroy, Marc A. Haffner, Philippe Petton, Bruno Cosseau, Céline Morga, Benjamin Dégremont, Lionel Mitta, Guillaume Grunau, Christoph Vidal-dupiol, Jeremie |
author_sort |
Gawra, Janan |
title |
Epigenetic then genetic variations underpin rapid adaptation of oyster populations (Crassostrea gigas) to Pacific Oyster Mortality Syndrome (POMS) |
title_short |
Epigenetic then genetic variations underpin rapid adaptation of oyster populations (Crassostrea gigas) to Pacific Oyster Mortality Syndrome (POMS) |
title_full |
Epigenetic then genetic variations underpin rapid adaptation of oyster populations (Crassostrea gigas) to Pacific Oyster Mortality Syndrome (POMS) |
title_fullStr |
Epigenetic then genetic variations underpin rapid adaptation of oyster populations (Crassostrea gigas) to Pacific Oyster Mortality Syndrome (POMS) |
title_full_unstemmed |
Epigenetic then genetic variations underpin rapid adaptation of oyster populations (Crassostrea gigas) to Pacific Oyster Mortality Syndrome (POMS) |
title_sort |
epigenetic then genetic variations underpin rapid adaptation of oyster populations (crassostrea gigas) to pacific oyster mortality syndrome (poms) |
publisher |
Cold Spring Harbor Laboratory |
publishDate |
2023 |
url |
https://archimer.ifremer.fr/doc/00827/93938/100727.pdf https://doi.org/10.1101/2023.03.09.531494 https://archimer.ifremer.fr/doc/00827/93938/ |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
BioRxiv (Cold Spring Harbor Laboratory) In Press |
op_relation |
https://archimer.ifremer.fr/doc/00827/93938/100727.pdf doi:10.1101/2023.03.09.531494 https://archimer.ifremer.fr/doc/00827/93938/ |
op_rights |
info:eu-repo/semantics/openAccess restricted use |
op_doi |
https://doi.org/10.1101/2023.03.09.531494 |
_version_ |
1766393750278373376 |