Increased growth metabolism promotes viral infection in a susceptible oyster population
The magnitude of an epidemic depends on host susceptibility to the disease, a trait influenced by the genetic constitution of the host and its environment. While the genetic basis of disease susceptibility is often associated with immune capacities, environmental effects generally reflect complex ph...
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ftarchimer:oai:archimer.ifremer.fr:93142 2023-05-15T15:58:53+02:00 Increased growth metabolism promotes viral infection in a susceptible oyster population Petton, Bruno Alunno-bruscia, Marianne Mitta, Guillaume Pernet, Fabrice 2023-02-02 application/pdf https://archimer.ifremer.fr/doc/00819/93142/99715.pdf https://archimer.ifremer.fr/doc/00819/93142/99716.pdf https://doi.org/10.3354/aei00450 https://archimer.ifremer.fr/doc/00819/93142/ eng eng Inter-Research Science Center https://archimer.ifremer.fr/doc/00819/93142/99715.pdf https://archimer.ifremer.fr/doc/00819/93142/99716.pdf doi:10.3354/aei00450 https://archimer.ifremer.fr/doc/00819/93142/ info:eu-repo/semantics/openAccess restricted use Aquaculture Environment Interactions (1869-215X) (Inter-Research Science Center), 2023-02-02 , Vol. 15 , P. 19-33 Epidemiology Growth · Health Metabolism Physiological trade-off Temperature text Publication info:eu-repo/semantics/article 2023 ftarchimer https://doi.org/10.3354/aei00450 2023-02-07T23:52:15Z The magnitude of an epidemic depends on host susceptibility to the disease, a trait influenced by the genetic constitution of the host and its environment. While the genetic basis of disease susceptibility is often associated with immune capacities, environmental effects generally reflect complex physiological trade-offs. We suggest here that in the case of obligate pathogens whose proliferation depends on the cellular machinery of the host (e.g. viruses), disease susceptibility is directly influenced by host growth. To test our hypothesis, we focussed on a viral disease affecting an ecologically relevant model exploited worldwide, the Pacific oyster Crassostrea gigas. Oysters originating from 3 lines with contrasting resistance to the disease were divided into 3 groups displaying different growth rates and acclimated to 3 food levels and 2 temperatures to generate different growth rates. These oysters were then exposed to the virus, and survival and viral shedding were measured. Finally, we developed a risk model to rank the relative importance of temperature, food, genetic selection and growth on disease-induced mortality. We found that increasing growth through temperature, food level or selection of fast-growing animals all increased mortality, especially in host populations where susceptible phenotypes dominated. Food provisioning was the most influential factor associated with higher viral shedding, followed by temperature, resistance phenotype and growth rate. We suggest that growth-forcing factors may promote the development of obligate intracellular pathogens and epidemic risk, thus opening up avenues for disease management based on the manipulation of host metabolism. Article in Journal/Newspaper Crassostrea gigas Pacific oyster Archimer (Archive Institutionnelle de l'Ifremer - Institut français de recherche pour l'exploitation de la mer) Pacific Aquaculture Environment Interactions 15 19 33 |
institution |
Open Polar |
collection |
Archimer (Archive Institutionnelle de l'Ifremer - Institut français de recherche pour l'exploitation de la mer) |
op_collection_id |
ftarchimer |
language |
English |
topic |
Epidemiology Growth · Health Metabolism Physiological trade-off Temperature |
spellingShingle |
Epidemiology Growth · Health Metabolism Physiological trade-off Temperature Petton, Bruno Alunno-bruscia, Marianne Mitta, Guillaume Pernet, Fabrice Increased growth metabolism promotes viral infection in a susceptible oyster population |
topic_facet |
Epidemiology Growth · Health Metabolism Physiological trade-off Temperature |
description |
The magnitude of an epidemic depends on host susceptibility to the disease, a trait influenced by the genetic constitution of the host and its environment. While the genetic basis of disease susceptibility is often associated with immune capacities, environmental effects generally reflect complex physiological trade-offs. We suggest here that in the case of obligate pathogens whose proliferation depends on the cellular machinery of the host (e.g. viruses), disease susceptibility is directly influenced by host growth. To test our hypothesis, we focussed on a viral disease affecting an ecologically relevant model exploited worldwide, the Pacific oyster Crassostrea gigas. Oysters originating from 3 lines with contrasting resistance to the disease were divided into 3 groups displaying different growth rates and acclimated to 3 food levels and 2 temperatures to generate different growth rates. These oysters were then exposed to the virus, and survival and viral shedding were measured. Finally, we developed a risk model to rank the relative importance of temperature, food, genetic selection and growth on disease-induced mortality. We found that increasing growth through temperature, food level or selection of fast-growing animals all increased mortality, especially in host populations where susceptible phenotypes dominated. Food provisioning was the most influential factor associated with higher viral shedding, followed by temperature, resistance phenotype and growth rate. We suggest that growth-forcing factors may promote the development of obligate intracellular pathogens and epidemic risk, thus opening up avenues for disease management based on the manipulation of host metabolism. |
format |
Article in Journal/Newspaper |
author |
Petton, Bruno Alunno-bruscia, Marianne Mitta, Guillaume Pernet, Fabrice |
author_facet |
Petton, Bruno Alunno-bruscia, Marianne Mitta, Guillaume Pernet, Fabrice |
author_sort |
Petton, Bruno |
title |
Increased growth metabolism promotes viral infection in a susceptible oyster population |
title_short |
Increased growth metabolism promotes viral infection in a susceptible oyster population |
title_full |
Increased growth metabolism promotes viral infection in a susceptible oyster population |
title_fullStr |
Increased growth metabolism promotes viral infection in a susceptible oyster population |
title_full_unstemmed |
Increased growth metabolism promotes viral infection in a susceptible oyster population |
title_sort |
increased growth metabolism promotes viral infection in a susceptible oyster population |
publisher |
Inter-Research Science Center |
publishDate |
2023 |
url |
https://archimer.ifremer.fr/doc/00819/93142/99715.pdf https://archimer.ifremer.fr/doc/00819/93142/99716.pdf https://doi.org/10.3354/aei00450 https://archimer.ifremer.fr/doc/00819/93142/ |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
Aquaculture Environment Interactions (1869-215X) (Inter-Research Science Center), 2023-02-02 , Vol. 15 , P. 19-33 |
op_relation |
https://archimer.ifremer.fr/doc/00819/93142/99715.pdf https://archimer.ifremer.fr/doc/00819/93142/99716.pdf doi:10.3354/aei00450 https://archimer.ifremer.fr/doc/00819/93142/ |
op_rights |
info:eu-repo/semantics/openAccess restricted use |
op_doi |
https://doi.org/10.3354/aei00450 |
container_title |
Aquaculture Environment Interactions |
container_volume |
15 |
container_start_page |
19 |
op_container_end_page |
33 |
_version_ |
1766394656628670464 |