Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection
Background The interaction of organisms with their surrounding microbial communities influences many biological processes, a notable example of which is the shaping of the immune system in early life. In the Pacific oyster, Crassostrea gigas, the role of the environmental microbial community on immu...
Published in: | Microbiome |
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Format: | Article in Journal/Newspaper |
Language: | English |
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BMC
2022
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Online Access: | https://archimer.ifremer.fr/doc/00753/86457/91789.docx https://archimer.ifremer.fr/doc/00753/86457/91790.xlsx https://archimer.ifremer.fr/doc/00753/86457/91791.docx https://archimer.ifremer.fr/doc/00753/86457/91793.xlsx https://archimer.ifremer.fr/doc/00753/86457/91794.xlsx https://archimer.ifremer.fr/doc/00753/86457/91795.xlsx https://archimer.ifremer.fr/doc/00753/86457/91796.xlsx https://archimer.ifremer.fr/doc/00753/86457/91797.xlsx https://archimer.ifremer.fr/doc/00753/86457/91798.xlsx https://archimer.ifremer.fr/doc/00753/86457/91799.xlsx https://archimer.ifremer.fr/doc/00753/86457/91800.xlsx https://archimer.ifremer.fr/doc/00753/86457/94478.pdf https://doi.org/10.1186/s40168-022-01280-5 https://archimer.ifremer.fr/doc/00753/86457/ |
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ftarchimer:oai:archimer.ifremer.fr:86457 2023-05-15T15:57:48+02:00 Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection Fallet, Manon Montagnani, Caroline Petton, Bruno Dantan, Luc De Lorgeril, Julien Comarmond, Sébastien Chaparro, Cristian Toulza, Eve Boitard, Simon Escoubas, Jean Michel Vergnes, Agnes Le Grand, Jacqueline Bulla, Ingo Gueguen, Yannick Vidal-dupiol, Jeremie Grunau, Christoph Mitta, Guillaume Cossau, Céline 2022-06 application/pdf https://archimer.ifremer.fr/doc/00753/86457/91789.docx https://archimer.ifremer.fr/doc/00753/86457/91790.xlsx https://archimer.ifremer.fr/doc/00753/86457/91791.docx https://archimer.ifremer.fr/doc/00753/86457/91793.xlsx https://archimer.ifremer.fr/doc/00753/86457/91794.xlsx https://archimer.ifremer.fr/doc/00753/86457/91795.xlsx https://archimer.ifremer.fr/doc/00753/86457/91796.xlsx https://archimer.ifremer.fr/doc/00753/86457/91797.xlsx https://archimer.ifremer.fr/doc/00753/86457/91798.xlsx https://archimer.ifremer.fr/doc/00753/86457/91799.xlsx https://archimer.ifremer.fr/doc/00753/86457/91800.xlsx https://archimer.ifremer.fr/doc/00753/86457/94478.pdf https://doi.org/10.1186/s40168-022-01280-5 https://archimer.ifremer.fr/doc/00753/86457/ eng eng BMC info:eu-repo/grantAgreement/EC/FP7/678589/EU//VIVALDI https://archimer.ifremer.fr/doc/00753/86457/91789.docx https://archimer.ifremer.fr/doc/00753/86457/91790.xlsx https://archimer.ifremer.fr/doc/00753/86457/91791.docx https://archimer.ifremer.fr/doc/00753/86457/91793.xlsx https://archimer.ifremer.fr/doc/00753/86457/91794.xlsx https://archimer.ifremer.fr/doc/00753/86457/91795.xlsx https://archimer.ifremer.fr/doc/00753/86457/91796.xlsx https://archimer.ifremer.fr/doc/00753/86457/91797.xlsx https://archimer.ifremer.fr/doc/00753/86457/91798.xlsx https://archimer.ifremer.fr/doc/00753/86457/91799.xlsx https://archimer.ifremer.fr/doc/00753/86457/91800.xlsx https://archimer.ifremer.fr/doc/00753/86457/94478.pdf doi:10.1186/s40168-022-01280-5 https://archimer.ifremer.fr/doc/00753/86457/ info:eu-repo/semantics/openAccess restricted use Microbiome (2049-2618) (BMC), 2022-06 , Vol. 10 , N. 1 , P. 85 (21p.) Oyster Aquaculture Microbiota Innate immune shaping Epigenetic DNA methylation text Publication info:eu-repo/semantics/article 2022 ftarchimer https://doi.org/10.1186/s40168-022-01280-5 2023-01-24T23:50:40Z Background The interaction of organisms with their surrounding microbial communities influences many biological processes, a notable example of which is the shaping of the immune system in early life. In the Pacific oyster, Crassostrea gigas, the role of the environmental microbial community on immune system maturation – and, importantly, protection from infectious disease – is still an open question. Results Here, we demonstrate that early life microbial exposure durably improves oyster survival when challenged with the pathogen causing Pacific Oyster Mortality Syndrome (POMS), both in the exposed generation and in the subsequent one. Combining microbiota, transcriptomic, genetic, and epigenetic analyses, we show that the microbial exposure induced changes in epigenetic marks and a reprogramming of immune gene expression leading to long-term and intergenerational immune protection against POMS. Conclusions We anticipate that this protection likely extends to additional pathogens and may prove to be an important new strategy for safeguarding oyster aquaculture efforts from infectious disease. Article in Journal/Newspaper Crassostrea gigas Pacific oyster Archimer (Archive Institutionnelle de l'Ifremer - Institut français de recherche pour l'exploitation de la mer) Pacific Microbiome 10 1 |
institution |
Open Polar |
collection |
Archimer (Archive Institutionnelle de l'Ifremer - Institut français de recherche pour l'exploitation de la mer) |
op_collection_id |
ftarchimer |
language |
English |
topic |
Oyster Aquaculture Microbiota Innate immune shaping Epigenetic DNA methylation |
spellingShingle |
Oyster Aquaculture Microbiota Innate immune shaping Epigenetic DNA methylation Fallet, Manon Montagnani, Caroline Petton, Bruno Dantan, Luc De Lorgeril, Julien Comarmond, Sébastien Chaparro, Cristian Toulza, Eve Boitard, Simon Escoubas, Jean Michel Vergnes, Agnes Le Grand, Jacqueline Bulla, Ingo Gueguen, Yannick Vidal-dupiol, Jeremie Grunau, Christoph Mitta, Guillaume Cossau, Céline Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection |
topic_facet |
Oyster Aquaculture Microbiota Innate immune shaping Epigenetic DNA methylation |
description |
Background The interaction of organisms with their surrounding microbial communities influences many biological processes, a notable example of which is the shaping of the immune system in early life. In the Pacific oyster, Crassostrea gigas, the role of the environmental microbial community on immune system maturation – and, importantly, protection from infectious disease – is still an open question. Results Here, we demonstrate that early life microbial exposure durably improves oyster survival when challenged with the pathogen causing Pacific Oyster Mortality Syndrome (POMS), both in the exposed generation and in the subsequent one. Combining microbiota, transcriptomic, genetic, and epigenetic analyses, we show that the microbial exposure induced changes in epigenetic marks and a reprogramming of immune gene expression leading to long-term and intergenerational immune protection against POMS. Conclusions We anticipate that this protection likely extends to additional pathogens and may prove to be an important new strategy for safeguarding oyster aquaculture efforts from infectious disease. |
format |
Article in Journal/Newspaper |
author |
Fallet, Manon Montagnani, Caroline Petton, Bruno Dantan, Luc De Lorgeril, Julien Comarmond, Sébastien Chaparro, Cristian Toulza, Eve Boitard, Simon Escoubas, Jean Michel Vergnes, Agnes Le Grand, Jacqueline Bulla, Ingo Gueguen, Yannick Vidal-dupiol, Jeremie Grunau, Christoph Mitta, Guillaume Cossau, Céline |
author_facet |
Fallet, Manon Montagnani, Caroline Petton, Bruno Dantan, Luc De Lorgeril, Julien Comarmond, Sébastien Chaparro, Cristian Toulza, Eve Boitard, Simon Escoubas, Jean Michel Vergnes, Agnes Le Grand, Jacqueline Bulla, Ingo Gueguen, Yannick Vidal-dupiol, Jeremie Grunau, Christoph Mitta, Guillaume Cossau, Céline |
author_sort |
Fallet, Manon |
title |
Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection |
title_short |
Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection |
title_full |
Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection |
title_fullStr |
Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection |
title_full_unstemmed |
Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection |
title_sort |
early life microbial exposures shape the crassostrea gigas immune system for lifelong and intergenerational disease protection |
publisher |
BMC |
publishDate |
2022 |
url |
https://archimer.ifremer.fr/doc/00753/86457/91789.docx https://archimer.ifremer.fr/doc/00753/86457/91790.xlsx https://archimer.ifremer.fr/doc/00753/86457/91791.docx https://archimer.ifremer.fr/doc/00753/86457/91793.xlsx https://archimer.ifremer.fr/doc/00753/86457/91794.xlsx https://archimer.ifremer.fr/doc/00753/86457/91795.xlsx https://archimer.ifremer.fr/doc/00753/86457/91796.xlsx https://archimer.ifremer.fr/doc/00753/86457/91797.xlsx https://archimer.ifremer.fr/doc/00753/86457/91798.xlsx https://archimer.ifremer.fr/doc/00753/86457/91799.xlsx https://archimer.ifremer.fr/doc/00753/86457/91800.xlsx https://archimer.ifremer.fr/doc/00753/86457/94478.pdf https://doi.org/10.1186/s40168-022-01280-5 https://archimer.ifremer.fr/doc/00753/86457/ |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
Microbiome (2049-2618) (BMC), 2022-06 , Vol. 10 , N. 1 , P. 85 (21p.) |
op_relation |
info:eu-repo/grantAgreement/EC/FP7/678589/EU//VIVALDI https://archimer.ifremer.fr/doc/00753/86457/91789.docx https://archimer.ifremer.fr/doc/00753/86457/91790.xlsx https://archimer.ifremer.fr/doc/00753/86457/91791.docx https://archimer.ifremer.fr/doc/00753/86457/91793.xlsx https://archimer.ifremer.fr/doc/00753/86457/91794.xlsx https://archimer.ifremer.fr/doc/00753/86457/91795.xlsx https://archimer.ifremer.fr/doc/00753/86457/91796.xlsx https://archimer.ifremer.fr/doc/00753/86457/91797.xlsx https://archimer.ifremer.fr/doc/00753/86457/91798.xlsx https://archimer.ifremer.fr/doc/00753/86457/91799.xlsx https://archimer.ifremer.fr/doc/00753/86457/91800.xlsx https://archimer.ifremer.fr/doc/00753/86457/94478.pdf doi:10.1186/s40168-022-01280-5 https://archimer.ifremer.fr/doc/00753/86457/ |
op_rights |
info:eu-repo/semantics/openAccess restricted use |
op_doi |
https://doi.org/10.1186/s40168-022-01280-5 |
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Microbiome |
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