High temperature induces transcriptomic changes in Crassostrea gigas that hinder progress of ostreid herpesvirus (OsHV-1) and promote survival
Of all environmental factors, seawater temperature plays a decisive role in triggering marine diseases. Like fever in vertebrates, high seawater temperature could modulate the host response to pathogens in ectothermic animals. In France, massive mortality of Pacific oysters, Crassostrea gigas, cause...
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ftarchimer:oai:archimer.ifremer.fr:76806 2023-10-25T01:37:50+02:00 High temperature induces transcriptomic changes in Crassostrea gigas that hinder progress of ostreid herpesvirus (OsHV-1) and promote survival Delisle, Lizenn Pauletto, Marianna Vidal-dupiol, Jeremie Petton, Bruno Bargelloni, Luca Montagnani, Caroline Pernet, Fabrice Corporeau, Charlotte Fleury, Elodie 2020-10 application/pdf https://archimer.ifremer.fr/doc/00656/76806/77974.pdf https://doi.org/10.1242/jeb.226233 https://archimer.ifremer.fr/doc/00656/76806/ eng eng The Company of Biologists info:eu-repo/grantAgreement/EC/FP7/678589/EU//VIVALDI https://archimer.ifremer.fr/doc/00656/76806/77974.pdf doi:10.1242/jeb.226233 https://archimer.ifremer.fr/doc/00656/76806/ info:eu-repo/semantics/openAccess restricted use Journal Of Experimental Biology (0022-0949) (The Company of Biologists), 2020-10 , Vol. 223 , N. 20 , P. jeb226233 (11p.) Anti-viral molecular pathway Host-pathogen interaction Marine disease OsHV-1 Resistance Temperature text Article info:eu-repo/semantics/article 2020 ftarchimer https://doi.org/10.1242/jeb.226233 2023-09-26T22:51:07Z Of all environmental factors, seawater temperature plays a decisive role in triggering marine diseases. Like fever in vertebrates, high seawater temperature could modulate the host response to pathogens in ectothermic animals. In France, massive mortality of Pacific oysters, Crassostrea gigas, caused by the ostreid herpesvirus 1 (OsHV-1) is markedly reduced when temperatures exceed 24°C in the field. In the present study we assess how high temperature influences the host response to the pathogen by comparing transcriptomes (RNA sequencing) during the course of experimental infection at 21°C (reference) and 29°C. We show that high temperature induced host physiological processes that are unfavorable to the viral infection. Temperature influenced the expression of transcripts related to the immune process and increased the transcription of genes related to the apoptotic process, synaptic signaling and protein processes at 29°C. Concomitantly, the expression of genes associated with catabolism, metabolite transport, macromolecule synthesis and cell growth remained low from the first stage of infection at 29°C. Moreover, viral entry into the host might have been limited at 29°C by changes in extracellular matrix composition and protein abundance. Overall, these results provide new insights into how environmental factors modulate host–pathogen interactions. Article in Journal/Newspaper Crassostrea gigas Archimer (Archive Institutionnelle de l'Ifremer - Institut français de recherche pour l'exploitation de la mer) Pacific Journal of Experimental Biology |
institution |
Open Polar |
collection |
Archimer (Archive Institutionnelle de l'Ifremer - Institut français de recherche pour l'exploitation de la mer) |
op_collection_id |
ftarchimer |
language |
English |
topic |
Anti-viral molecular pathway Host-pathogen interaction Marine disease OsHV-1 Resistance Temperature |
spellingShingle |
Anti-viral molecular pathway Host-pathogen interaction Marine disease OsHV-1 Resistance Temperature Delisle, Lizenn Pauletto, Marianna Vidal-dupiol, Jeremie Petton, Bruno Bargelloni, Luca Montagnani, Caroline Pernet, Fabrice Corporeau, Charlotte Fleury, Elodie High temperature induces transcriptomic changes in Crassostrea gigas that hinder progress of ostreid herpesvirus (OsHV-1) and promote survival |
topic_facet |
Anti-viral molecular pathway Host-pathogen interaction Marine disease OsHV-1 Resistance Temperature |
description |
Of all environmental factors, seawater temperature plays a decisive role in triggering marine diseases. Like fever in vertebrates, high seawater temperature could modulate the host response to pathogens in ectothermic animals. In France, massive mortality of Pacific oysters, Crassostrea gigas, caused by the ostreid herpesvirus 1 (OsHV-1) is markedly reduced when temperatures exceed 24°C in the field. In the present study we assess how high temperature influences the host response to the pathogen by comparing transcriptomes (RNA sequencing) during the course of experimental infection at 21°C (reference) and 29°C. We show that high temperature induced host physiological processes that are unfavorable to the viral infection. Temperature influenced the expression of transcripts related to the immune process and increased the transcription of genes related to the apoptotic process, synaptic signaling and protein processes at 29°C. Concomitantly, the expression of genes associated with catabolism, metabolite transport, macromolecule synthesis and cell growth remained low from the first stage of infection at 29°C. Moreover, viral entry into the host might have been limited at 29°C by changes in extracellular matrix composition and protein abundance. Overall, these results provide new insights into how environmental factors modulate host–pathogen interactions. |
format |
Article in Journal/Newspaper |
author |
Delisle, Lizenn Pauletto, Marianna Vidal-dupiol, Jeremie Petton, Bruno Bargelloni, Luca Montagnani, Caroline Pernet, Fabrice Corporeau, Charlotte Fleury, Elodie |
author_facet |
Delisle, Lizenn Pauletto, Marianna Vidal-dupiol, Jeremie Petton, Bruno Bargelloni, Luca Montagnani, Caroline Pernet, Fabrice Corporeau, Charlotte Fleury, Elodie |
author_sort |
Delisle, Lizenn |
title |
High temperature induces transcriptomic changes in Crassostrea gigas that hinder progress of ostreid herpesvirus (OsHV-1) and promote survival |
title_short |
High temperature induces transcriptomic changes in Crassostrea gigas that hinder progress of ostreid herpesvirus (OsHV-1) and promote survival |
title_full |
High temperature induces transcriptomic changes in Crassostrea gigas that hinder progress of ostreid herpesvirus (OsHV-1) and promote survival |
title_fullStr |
High temperature induces transcriptomic changes in Crassostrea gigas that hinder progress of ostreid herpesvirus (OsHV-1) and promote survival |
title_full_unstemmed |
High temperature induces transcriptomic changes in Crassostrea gigas that hinder progress of ostreid herpesvirus (OsHV-1) and promote survival |
title_sort |
high temperature induces transcriptomic changes in crassostrea gigas that hinder progress of ostreid herpesvirus (oshv-1) and promote survival |
publisher |
The Company of Biologists |
publishDate |
2020 |
url |
https://archimer.ifremer.fr/doc/00656/76806/77974.pdf https://doi.org/10.1242/jeb.226233 https://archimer.ifremer.fr/doc/00656/76806/ |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas |
genre_facet |
Crassostrea gigas |
op_source |
Journal Of Experimental Biology (0022-0949) (The Company of Biologists), 2020-10 , Vol. 223 , N. 20 , P. jeb226233 (11p.) |
op_relation |
info:eu-repo/grantAgreement/EC/FP7/678589/EU//VIVALDI https://archimer.ifremer.fr/doc/00656/76806/77974.pdf doi:10.1242/jeb.226233 https://archimer.ifremer.fr/doc/00656/76806/ |
op_rights |
info:eu-repo/semantics/openAccess restricted use |
op_doi |
https://doi.org/10.1242/jeb.226233 |
container_title |
Journal of Experimental Biology |
_version_ |
1780732806722224128 |