A Sustained Immune Response Supports Long-Term Antiviral Immune Priming in the Pacific Oyster, Crassostrea gigas
Over the last decade, innate immune priming has been evidenced in many invertebrate phyla. If mechanistic models have been proposed, molecular studies aiming to substantiate these models have remained scarce. We reveal here the transcriptional signature associated with immune priming in the oyster C...
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Main Authors: | , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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American Society for Microbiology
2020
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Online Access: | https://archimer.ifremer.fr/doc/00614/72580/71541.pdf https://archimer.ifremer.fr/doc/00614/72580/71542.xlsx https://archimer.ifremer.fr/doc/00614/72580/71543.tif https://archimer.ifremer.fr/doc/00614/72580/71544.tif https://archimer.ifremer.fr/doc/00614/72580/71545.xlsx https://archimer.ifremer.fr/doc/00614/72580/71546.xlsx https://archimer.ifremer.fr/doc/00614/72580/71547.eps https://archimer.ifremer.fr/doc/00614/72580/71548.xlsx https://archimer.ifremer.fr/doc/00614/72580/71549.xlsx https://archimer.ifremer.fr/doc/00614/72580/71550.tif https://archimer.ifremer.fr/doc/00614/72580/71551.tif https://doi.org/10.1128/mBio.02777-19 https://archimer.ifremer.fr/doc/00614/72580/ |
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ftarchimer:oai:archimer.ifremer.fr:72580 2023-11-12T04:16:08+01:00 A Sustained Immune Response Supports Long-Term Antiviral Immune Priming in the Pacific Oyster, Crassostrea gigas Lafont, Maxime Vergnes, Agnes Vidal-dupiol, Jeremie De Lorgeril, Julien Gueguen, Yannick Haffner, Philippe Petton, Bruno Chaparro, Cristian Barrachina, Celia Destoumieux-garzon, Delphine Mitta, Guillaume Gourbal, Benjamin Montagnani, Caroline 2020-03 application/pdf https://archimer.ifremer.fr/doc/00614/72580/71541.pdf https://archimer.ifremer.fr/doc/00614/72580/71542.xlsx https://archimer.ifremer.fr/doc/00614/72580/71543.tif https://archimer.ifremer.fr/doc/00614/72580/71544.tif https://archimer.ifremer.fr/doc/00614/72580/71545.xlsx https://archimer.ifremer.fr/doc/00614/72580/71546.xlsx https://archimer.ifremer.fr/doc/00614/72580/71547.eps https://archimer.ifremer.fr/doc/00614/72580/71548.xlsx https://archimer.ifremer.fr/doc/00614/72580/71549.xlsx https://archimer.ifremer.fr/doc/00614/72580/71550.tif https://archimer.ifremer.fr/doc/00614/72580/71551.tif https://doi.org/10.1128/mBio.02777-19 https://archimer.ifremer.fr/doc/00614/72580/ eng eng American Society for Microbiology info:eu-repo/grantAgreement/EC/FP7/678589/EU//VIVALDI https://archimer.ifremer.fr/doc/00614/72580/71541.pdf https://archimer.ifremer.fr/doc/00614/72580/71542.xlsx https://archimer.ifremer.fr/doc/00614/72580/71543.tif https://archimer.ifremer.fr/doc/00614/72580/71544.tif https://archimer.ifremer.fr/doc/00614/72580/71545.xlsx https://archimer.ifremer.fr/doc/00614/72580/71546.xlsx https://archimer.ifremer.fr/doc/00614/72580/71547.eps https://archimer.ifremer.fr/doc/00614/72580/71548.xlsx https://archimer.ifremer.fr/doc/00614/72580/71549.xlsx https://archimer.ifremer.fr/doc/00614/72580/71550.tif https://archimer.ifremer.fr/doc/00614/72580/71551.tif doi:10.1128/mBio.02777-19 https://archimer.ifremer.fr/doc/00614/72580/ info:eu-repo/semantics/openAccess restricted use Mbio (2150-7511) (American Society for Microbiology), 2020-03 , Vol. 11 , N. 2 , P. e02777-19 (17p.) innate immunity priming OsHV-1 antiviral response immune memory oyster POMS poly(I-C) interferon transcriptomic text Article info:eu-repo/semantics/article 2020 ftarchimer https://doi.org/10.1128/mBio.02777-19 2023-10-17T22:51:11Z Over the last decade, innate immune priming has been evidenced in many invertebrate phyla. If mechanistic models have been proposed, molecular studies aiming to substantiate these models have remained scarce. We reveal here the transcriptional signature associated with immune priming in the oyster Crassostrea gigas. Oysters were fully protected against Ostreid herpesvirus 1 (OsHV-1), a major oyster pathogen, after priming with poly(I·C), which mimics viral double-stranded RNA. Global analysis through RNA sequencing of oyster and viral genes after immune priming and viral infection revealed that poly(I·C) induces a strong antiviral response that impairs OsHV-1 replication. Protection is based on a sustained upregulation of immune genes, notably genes involved in the interferon pathway and apoptosis, which control subsequent viral infection. This persistent antiviral alert state remains active over 4 months and supports antiviral protection in the long term. This acquired resistance mechanism reinforces the molecular foundations of the sustained response model of immune priming. It further opens the way to applications (pseudovaccination) to cope with a recurrent disease that causes dramatic economic losses in the shellfish farming industry worldwide. Article in Journal/Newspaper Crassostrea gigas Pacific oyster Archimer (Archive Institutionnelle de l'Ifremer - Institut français de recherche pour l'exploitation de la mer) Pacific mBio 11 2 |
institution |
Open Polar |
collection |
Archimer (Archive Institutionnelle de l'Ifremer - Institut français de recherche pour l'exploitation de la mer) |
op_collection_id |
ftarchimer |
language |
English |
topic |
innate immunity priming OsHV-1 antiviral response immune memory oyster POMS poly(I-C) interferon transcriptomic |
spellingShingle |
innate immunity priming OsHV-1 antiviral response immune memory oyster POMS poly(I-C) interferon transcriptomic Lafont, Maxime Vergnes, Agnes Vidal-dupiol, Jeremie De Lorgeril, Julien Gueguen, Yannick Haffner, Philippe Petton, Bruno Chaparro, Cristian Barrachina, Celia Destoumieux-garzon, Delphine Mitta, Guillaume Gourbal, Benjamin Montagnani, Caroline A Sustained Immune Response Supports Long-Term Antiviral Immune Priming in the Pacific Oyster, Crassostrea gigas |
topic_facet |
innate immunity priming OsHV-1 antiviral response immune memory oyster POMS poly(I-C) interferon transcriptomic |
description |
Over the last decade, innate immune priming has been evidenced in many invertebrate phyla. If mechanistic models have been proposed, molecular studies aiming to substantiate these models have remained scarce. We reveal here the transcriptional signature associated with immune priming in the oyster Crassostrea gigas. Oysters were fully protected against Ostreid herpesvirus 1 (OsHV-1), a major oyster pathogen, after priming with poly(I·C), which mimics viral double-stranded RNA. Global analysis through RNA sequencing of oyster and viral genes after immune priming and viral infection revealed that poly(I·C) induces a strong antiviral response that impairs OsHV-1 replication. Protection is based on a sustained upregulation of immune genes, notably genes involved in the interferon pathway and apoptosis, which control subsequent viral infection. This persistent antiviral alert state remains active over 4 months and supports antiviral protection in the long term. This acquired resistance mechanism reinforces the molecular foundations of the sustained response model of immune priming. It further opens the way to applications (pseudovaccination) to cope with a recurrent disease that causes dramatic economic losses in the shellfish farming industry worldwide. |
format |
Article in Journal/Newspaper |
author |
Lafont, Maxime Vergnes, Agnes Vidal-dupiol, Jeremie De Lorgeril, Julien Gueguen, Yannick Haffner, Philippe Petton, Bruno Chaparro, Cristian Barrachina, Celia Destoumieux-garzon, Delphine Mitta, Guillaume Gourbal, Benjamin Montagnani, Caroline |
author_facet |
Lafont, Maxime Vergnes, Agnes Vidal-dupiol, Jeremie De Lorgeril, Julien Gueguen, Yannick Haffner, Philippe Petton, Bruno Chaparro, Cristian Barrachina, Celia Destoumieux-garzon, Delphine Mitta, Guillaume Gourbal, Benjamin Montagnani, Caroline |
author_sort |
Lafont, Maxime |
title |
A Sustained Immune Response Supports Long-Term Antiviral Immune Priming in the Pacific Oyster, Crassostrea gigas |
title_short |
A Sustained Immune Response Supports Long-Term Antiviral Immune Priming in the Pacific Oyster, Crassostrea gigas |
title_full |
A Sustained Immune Response Supports Long-Term Antiviral Immune Priming in the Pacific Oyster, Crassostrea gigas |
title_fullStr |
A Sustained Immune Response Supports Long-Term Antiviral Immune Priming in the Pacific Oyster, Crassostrea gigas |
title_full_unstemmed |
A Sustained Immune Response Supports Long-Term Antiviral Immune Priming in the Pacific Oyster, Crassostrea gigas |
title_sort |
sustained immune response supports long-term antiviral immune priming in the pacific oyster, crassostrea gigas |
publisher |
American Society for Microbiology |
publishDate |
2020 |
url |
https://archimer.ifremer.fr/doc/00614/72580/71541.pdf https://archimer.ifremer.fr/doc/00614/72580/71542.xlsx https://archimer.ifremer.fr/doc/00614/72580/71543.tif https://archimer.ifremer.fr/doc/00614/72580/71544.tif https://archimer.ifremer.fr/doc/00614/72580/71545.xlsx https://archimer.ifremer.fr/doc/00614/72580/71546.xlsx https://archimer.ifremer.fr/doc/00614/72580/71547.eps https://archimer.ifremer.fr/doc/00614/72580/71548.xlsx https://archimer.ifremer.fr/doc/00614/72580/71549.xlsx https://archimer.ifremer.fr/doc/00614/72580/71550.tif https://archimer.ifremer.fr/doc/00614/72580/71551.tif https://doi.org/10.1128/mBio.02777-19 https://archimer.ifremer.fr/doc/00614/72580/ |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
Mbio (2150-7511) (American Society for Microbiology), 2020-03 , Vol. 11 , N. 2 , P. e02777-19 (17p.) |
op_relation |
info:eu-repo/grantAgreement/EC/FP7/678589/EU//VIVALDI https://archimer.ifremer.fr/doc/00614/72580/71541.pdf https://archimer.ifremer.fr/doc/00614/72580/71542.xlsx https://archimer.ifremer.fr/doc/00614/72580/71543.tif https://archimer.ifremer.fr/doc/00614/72580/71544.tif https://archimer.ifremer.fr/doc/00614/72580/71545.xlsx https://archimer.ifremer.fr/doc/00614/72580/71546.xlsx https://archimer.ifremer.fr/doc/00614/72580/71547.eps https://archimer.ifremer.fr/doc/00614/72580/71548.xlsx https://archimer.ifremer.fr/doc/00614/72580/71549.xlsx https://archimer.ifremer.fr/doc/00614/72580/71550.tif https://archimer.ifremer.fr/doc/00614/72580/71551.tif doi:10.1128/mBio.02777-19 https://archimer.ifremer.fr/doc/00614/72580/ |
op_rights |
info:eu-repo/semantics/openAccess restricted use |
op_doi |
https://doi.org/10.1128/mBio.02777-19 |
container_title |
mBio |
container_volume |
11 |
container_issue |
2 |
_version_ |
1782333298617352192 |