Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters
Infectious diseases are mostly explored using reductionist approaches despite repeated evidence showing them to be strongly in fluenced by numerous interacting host and environmental factors. Many diseases with a complex aetiology therefore remain misunderstood. By developing a holistic approach to...
Published in: | Nature Communications |
---|---|
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Nature Publishing Group
2018
|
Subjects: | |
Online Access: | https://archimer.ifremer.fr/doc/00461/57234/59228.pdf https://archimer.ifremer.fr/doc/00461/57234/59289.pdf https://archimer.ifremer.fr/doc/00461/57234/59290.pdf https://archimer.ifremer.fr/doc/00461/57234/59291.pdf https://archimer.ifremer.fr/doc/00461/57234/59292.xlsx https://archimer.ifremer.fr/doc/00461/57234/59293.xlsx https://archimer.ifremer.fr/doc/00461/57234/59294.xlsx https://archimer.ifremer.fr/doc/00461/57234/59295.xlsx https://archimer.ifremer.fr/doc/00461/57234/59296.xlsx https://archimer.ifremer.fr/doc/00461/57234/59297.xlsx https://doi.org/10.1038/s41467-018-06659-3 https://archimer.ifremer.fr/doc/00461/57234/ |
id |
ftarchimer:oai:archimer.ifremer.fr:57234 |
---|---|
record_format |
openpolar |
spelling |
ftarchimer:oai:archimer.ifremer.fr:57234 2023-05-15T15:58:31+02:00 Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters De Lorgeril, Julien Lucasson, Aude Petton, Bruno Toulza, Eve Montagnani, Caroline Clerissi, Camille Vidal-dupiol, Jeremie Chaparro, Cristian Galinier, Richard Escoubas, Jean Michel Haffner, Philippe Degremont, Lionel Charriere, Guillaume Lafont, Maxime Delort, Abigail Vergnes, Agnes Chiarello, Marlene Faury, Nicole Rubio, Tristan Leroy, Marc Perignon, Adeline Regler, Denis Morga, Benjamin Alunno-bruscia, Marianne Boudry, Pierre Le Roux, Frederique Destoumieux-garzon, Delphine Gueguen, Yannick Mitta, Guillaume 2018-10 application/pdf https://archimer.ifremer.fr/doc/00461/57234/59228.pdf https://archimer.ifremer.fr/doc/00461/57234/59289.pdf https://archimer.ifremer.fr/doc/00461/57234/59290.pdf https://archimer.ifremer.fr/doc/00461/57234/59291.pdf https://archimer.ifremer.fr/doc/00461/57234/59292.xlsx https://archimer.ifremer.fr/doc/00461/57234/59293.xlsx https://archimer.ifremer.fr/doc/00461/57234/59294.xlsx https://archimer.ifremer.fr/doc/00461/57234/59295.xlsx https://archimer.ifremer.fr/doc/00461/57234/59296.xlsx https://archimer.ifremer.fr/doc/00461/57234/59297.xlsx https://doi.org/10.1038/s41467-018-06659-3 https://archimer.ifremer.fr/doc/00461/57234/ eng eng Nature Publishing Group info:eu-repo/grantAgreement/EC/FP7/678589/EU//VIVALDI https://archimer.ifremer.fr/doc/00461/57234/59228.pdf https://archimer.ifremer.fr/doc/00461/57234/59289.pdf https://archimer.ifremer.fr/doc/00461/57234/59290.pdf https://archimer.ifremer.fr/doc/00461/57234/59291.pdf https://archimer.ifremer.fr/doc/00461/57234/59292.xlsx https://archimer.ifremer.fr/doc/00461/57234/59293.xlsx https://archimer.ifremer.fr/doc/00461/57234/59294.xlsx https://archimer.ifremer.fr/doc/00461/57234/59295.xlsx https://archimer.ifremer.fr/doc/00461/57234/59296.xlsx https://archimer.ifremer.fr/doc/00461/57234/59297.xlsx doi:10.1038/s41467-018-06659-3 https://archimer.ifremer.fr/doc/00461/57234/ The Author(s) 2018 info:eu-repo/semantics/openAccess restricted use Nature Communications (2041-1723) (Nature Publishing Group), 2018-10 , Vol. 9 , N. 4215 , P. 14p. text Publication info:eu-repo/semantics/article 2018 ftarchimer https://doi.org/10.1038/s41467-018-06659-3 2021-09-23T20:31:38Z Infectious diseases are mostly explored using reductionist approaches despite repeated evidence showing them to be strongly in fluenced by numerous interacting host and environmental factors. Many diseases with a complex aetiology therefore remain misunderstood. By developing a holistic approach to tackle the complexity of interactions, we decipher the complex intra-host interactions underlying Pacific oyster mortality syndrome affecting juveniles of Crassostrea gigas, the main oyster species exploited worldwide. Using experimental infections reproducing the natural route of infection and combining thorough molecular analyses of oyster families with contrasted susceptibilities, we demonstrate that the disease is caused by multiple infection with an initial and necessary step of infection of oyster haemocytes by the Ostreid herpesvirus OsHV-1 μVar. Viral replication leads to the host entering an immune-compromised state, evolving towards subsequent bacteraemia by opportunistic bacteria. We propose the application of our integrative approach to decipher other multifactorial diseases that affect non-model species worldwide. Article in Journal/Newspaper Crassostrea gigas Pacific oyster Archimer (Archive Institutionnelle de l'Ifremer - Institut français de recherche pour l'exploitation de la mer) Pacific Nature Communications 9 1 |
institution |
Open Polar |
collection |
Archimer (Archive Institutionnelle de l'Ifremer - Institut français de recherche pour l'exploitation de la mer) |
op_collection_id |
ftarchimer |
language |
English |
description |
Infectious diseases are mostly explored using reductionist approaches despite repeated evidence showing them to be strongly in fluenced by numerous interacting host and environmental factors. Many diseases with a complex aetiology therefore remain misunderstood. By developing a holistic approach to tackle the complexity of interactions, we decipher the complex intra-host interactions underlying Pacific oyster mortality syndrome affecting juveniles of Crassostrea gigas, the main oyster species exploited worldwide. Using experimental infections reproducing the natural route of infection and combining thorough molecular analyses of oyster families with contrasted susceptibilities, we demonstrate that the disease is caused by multiple infection with an initial and necessary step of infection of oyster haemocytes by the Ostreid herpesvirus OsHV-1 μVar. Viral replication leads to the host entering an immune-compromised state, evolving towards subsequent bacteraemia by opportunistic bacteria. We propose the application of our integrative approach to decipher other multifactorial diseases that affect non-model species worldwide. |
format |
Article in Journal/Newspaper |
author |
De Lorgeril, Julien Lucasson, Aude Petton, Bruno Toulza, Eve Montagnani, Caroline Clerissi, Camille Vidal-dupiol, Jeremie Chaparro, Cristian Galinier, Richard Escoubas, Jean Michel Haffner, Philippe Degremont, Lionel Charriere, Guillaume Lafont, Maxime Delort, Abigail Vergnes, Agnes Chiarello, Marlene Faury, Nicole Rubio, Tristan Leroy, Marc Perignon, Adeline Regler, Denis Morga, Benjamin Alunno-bruscia, Marianne Boudry, Pierre Le Roux, Frederique Destoumieux-garzon, Delphine Gueguen, Yannick Mitta, Guillaume |
spellingShingle |
De Lorgeril, Julien Lucasson, Aude Petton, Bruno Toulza, Eve Montagnani, Caroline Clerissi, Camille Vidal-dupiol, Jeremie Chaparro, Cristian Galinier, Richard Escoubas, Jean Michel Haffner, Philippe Degremont, Lionel Charriere, Guillaume Lafont, Maxime Delort, Abigail Vergnes, Agnes Chiarello, Marlene Faury, Nicole Rubio, Tristan Leroy, Marc Perignon, Adeline Regler, Denis Morga, Benjamin Alunno-bruscia, Marianne Boudry, Pierre Le Roux, Frederique Destoumieux-garzon, Delphine Gueguen, Yannick Mitta, Guillaume Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters |
author_facet |
De Lorgeril, Julien Lucasson, Aude Petton, Bruno Toulza, Eve Montagnani, Caroline Clerissi, Camille Vidal-dupiol, Jeremie Chaparro, Cristian Galinier, Richard Escoubas, Jean Michel Haffner, Philippe Degremont, Lionel Charriere, Guillaume Lafont, Maxime Delort, Abigail Vergnes, Agnes Chiarello, Marlene Faury, Nicole Rubio, Tristan Leroy, Marc Perignon, Adeline Regler, Denis Morga, Benjamin Alunno-bruscia, Marianne Boudry, Pierre Le Roux, Frederique Destoumieux-garzon, Delphine Gueguen, Yannick Mitta, Guillaume |
author_sort |
De Lorgeril, Julien |
title |
Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters |
title_short |
Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters |
title_full |
Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters |
title_fullStr |
Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters |
title_full_unstemmed |
Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters |
title_sort |
immune-suppression by oshv-1 viral infection causes fatal bacteraemia in pacific oysters |
publisher |
Nature Publishing Group |
publishDate |
2018 |
url |
https://archimer.ifremer.fr/doc/00461/57234/59228.pdf https://archimer.ifremer.fr/doc/00461/57234/59289.pdf https://archimer.ifremer.fr/doc/00461/57234/59290.pdf https://archimer.ifremer.fr/doc/00461/57234/59291.pdf https://archimer.ifremer.fr/doc/00461/57234/59292.xlsx https://archimer.ifremer.fr/doc/00461/57234/59293.xlsx https://archimer.ifremer.fr/doc/00461/57234/59294.xlsx https://archimer.ifremer.fr/doc/00461/57234/59295.xlsx https://archimer.ifremer.fr/doc/00461/57234/59296.xlsx https://archimer.ifremer.fr/doc/00461/57234/59297.xlsx https://doi.org/10.1038/s41467-018-06659-3 https://archimer.ifremer.fr/doc/00461/57234/ |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
Nature Communications (2041-1723) (Nature Publishing Group), 2018-10 , Vol. 9 , N. 4215 , P. 14p. |
op_relation |
info:eu-repo/grantAgreement/EC/FP7/678589/EU//VIVALDI https://archimer.ifremer.fr/doc/00461/57234/59228.pdf https://archimer.ifremer.fr/doc/00461/57234/59289.pdf https://archimer.ifremer.fr/doc/00461/57234/59290.pdf https://archimer.ifremer.fr/doc/00461/57234/59291.pdf https://archimer.ifremer.fr/doc/00461/57234/59292.xlsx https://archimer.ifremer.fr/doc/00461/57234/59293.xlsx https://archimer.ifremer.fr/doc/00461/57234/59294.xlsx https://archimer.ifremer.fr/doc/00461/57234/59295.xlsx https://archimer.ifremer.fr/doc/00461/57234/59296.xlsx https://archimer.ifremer.fr/doc/00461/57234/59297.xlsx doi:10.1038/s41467-018-06659-3 https://archimer.ifremer.fr/doc/00461/57234/ |
op_rights |
The Author(s) 2018 info:eu-repo/semantics/openAccess restricted use |
op_doi |
https://doi.org/10.1038/s41467-018-06659-3 |
container_title |
Nature Communications |
container_volume |
9 |
container_issue |
1 |
_version_ |
1766394261035548672 |