The new insights into the oyster antimicrobial defense: Cellular, molecular and genetic view
Oysters are sessile filter feeders that live in close association with abundant and diverse communities of microorganisms that form the oyster microbiota. In such an association, cellular and molecular mechanisms have evolved to maintain oyster homeostasis upon stressful conditions including infecti...
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ftarchimer:oai:archimer.ifremer.fr:36552 2023-05-15T15:58:43+02:00 The new insights into the oyster antimicrobial defense: Cellular, molecular and genetic view Bachere, Evelyne Rosa, Rafael Diego Schmitt, Paulina Poirier, Aurore Merou, Nicolas Charriere, Guillaume Destoumieux-garzon, Delphine 2015-09 application/pdf https://archimer.ifremer.fr/doc/00254/36552/35097.pdf https://doi.org/10.1016/j.fsi.2015.02.040 https://archimer.ifremer.fr/doc/00254/36552/ eng eng Academic Press Ltd- Elsevier Science Ltd https://archimer.ifremer.fr/doc/00254/36552/35097.pdf doi:10.1016/j.fsi.2015.02.040 https://archimer.ifremer.fr/doc/00254/36552/ 2015 Elsevier Ltd. All rights reserved. info:eu-repo/semantics/openAccess restricted use Fish & Shellfish Immunology (1050-4648) (Academic Press Ltd- Elsevier Science Ltd), 2015-09 , Vol. 46 , N. 1 , P. 50-64 Mollusk Immunity Antimicrobial peptide Hemocyte Defensin text Publication info:eu-repo/semantics/article 2015 ftarchimer https://doi.org/10.1016/j.fsi.2015.02.040 2021-09-23T20:25:56Z Oysters are sessile filter feeders that live in close association with abundant and diverse communities of microorganisms that form the oyster microbiota. In such an association, cellular and molecular mechanisms have evolved to maintain oyster homeostasis upon stressful conditions including infection and changing environments. We give here cellular and molecular insights into the Crassostrea gigas antimicrobial defense system with focus on antimicrobial peptides and proteins (AMPs). This review highlights the central role of the hemocytes in the modulation and control of oyster antimicrobial response. As vehicles for AMPs and other antimicrobial effectors, including reactive oxygen species (ROS), and together with epithelia, hemocytes provide the oyster with local defense reactions instead of systemic humoral ones. These reactions are largely based on phagocytosis but also, as recently described, on the extracellular release of antimicrobial histones (ETosis) which is triggered by ROS. Thus, ROS can signal danger and activate cellular responses in the oyster. From the current literature, AMP production/release could serve similar functions. We provide also new lights on the oyster genetic background that underlies a great diversity of AMP sequences but also an extraordinary individual polymorphism of AMP gene expression. We discuss here how this polymorphism could generate new immune functions, new pathogen resistances or support individual adaptation to environmental stresses. Article in Journal/Newspaper Crassostrea gigas Archimer (Archive Institutionnelle de l'Ifremer - Institut français de recherche pour l'exploitation de la mer) Fish & Shellfish Immunology 46 1 50 64 |
institution |
Open Polar |
collection |
Archimer (Archive Institutionnelle de l'Ifremer - Institut français de recherche pour l'exploitation de la mer) |
op_collection_id |
ftarchimer |
language |
English |
topic |
Mollusk Immunity Antimicrobial peptide Hemocyte Defensin |
spellingShingle |
Mollusk Immunity Antimicrobial peptide Hemocyte Defensin Bachere, Evelyne Rosa, Rafael Diego Schmitt, Paulina Poirier, Aurore Merou, Nicolas Charriere, Guillaume Destoumieux-garzon, Delphine The new insights into the oyster antimicrobial defense: Cellular, molecular and genetic view |
topic_facet |
Mollusk Immunity Antimicrobial peptide Hemocyte Defensin |
description |
Oysters are sessile filter feeders that live in close association with abundant and diverse communities of microorganisms that form the oyster microbiota. In such an association, cellular and molecular mechanisms have evolved to maintain oyster homeostasis upon stressful conditions including infection and changing environments. We give here cellular and molecular insights into the Crassostrea gigas antimicrobial defense system with focus on antimicrobial peptides and proteins (AMPs). This review highlights the central role of the hemocytes in the modulation and control of oyster antimicrobial response. As vehicles for AMPs and other antimicrobial effectors, including reactive oxygen species (ROS), and together with epithelia, hemocytes provide the oyster with local defense reactions instead of systemic humoral ones. These reactions are largely based on phagocytosis but also, as recently described, on the extracellular release of antimicrobial histones (ETosis) which is triggered by ROS. Thus, ROS can signal danger and activate cellular responses in the oyster. From the current literature, AMP production/release could serve similar functions. We provide also new lights on the oyster genetic background that underlies a great diversity of AMP sequences but also an extraordinary individual polymorphism of AMP gene expression. We discuss here how this polymorphism could generate new immune functions, new pathogen resistances or support individual adaptation to environmental stresses. |
format |
Article in Journal/Newspaper |
author |
Bachere, Evelyne Rosa, Rafael Diego Schmitt, Paulina Poirier, Aurore Merou, Nicolas Charriere, Guillaume Destoumieux-garzon, Delphine |
author_facet |
Bachere, Evelyne Rosa, Rafael Diego Schmitt, Paulina Poirier, Aurore Merou, Nicolas Charriere, Guillaume Destoumieux-garzon, Delphine |
author_sort |
Bachere, Evelyne |
title |
The new insights into the oyster antimicrobial defense: Cellular, molecular and genetic view |
title_short |
The new insights into the oyster antimicrobial defense: Cellular, molecular and genetic view |
title_full |
The new insights into the oyster antimicrobial defense: Cellular, molecular and genetic view |
title_fullStr |
The new insights into the oyster antimicrobial defense: Cellular, molecular and genetic view |
title_full_unstemmed |
The new insights into the oyster antimicrobial defense: Cellular, molecular and genetic view |
title_sort |
new insights into the oyster antimicrobial defense: cellular, molecular and genetic view |
publisher |
Academic Press Ltd- Elsevier Science Ltd |
publishDate |
2015 |
url |
https://archimer.ifremer.fr/doc/00254/36552/35097.pdf https://doi.org/10.1016/j.fsi.2015.02.040 https://archimer.ifremer.fr/doc/00254/36552/ |
genre |
Crassostrea gigas |
genre_facet |
Crassostrea gigas |
op_source |
Fish & Shellfish Immunology (1050-4648) (Academic Press Ltd- Elsevier Science Ltd), 2015-09 , Vol. 46 , N. 1 , P. 50-64 |
op_relation |
https://archimer.ifremer.fr/doc/00254/36552/35097.pdf doi:10.1016/j.fsi.2015.02.040 https://archimer.ifremer.fr/doc/00254/36552/ |
op_rights |
2015 Elsevier Ltd. All rights reserved. info:eu-repo/semantics/openAccess restricted use |
op_doi |
https://doi.org/10.1016/j.fsi.2015.02.040 |
container_title |
Fish & Shellfish Immunology |
container_volume |
46 |
container_issue |
1 |
container_start_page |
50 |
op_container_end_page |
64 |
_version_ |
1766394488667766784 |