The use of platelet monoamine oxidase-B as a biomarker for mercury neurotoxic effects among Inuit in Arctic Canada.
Mercury (Hg) is a widespread neurotoxin, therefore it is important to identify a biomarker of effect in populations that could be at risk of Hg exposure. Platelet monoamine oxidase (MAO) could be a biomarker since animal studies indicate that brain and platelet MAO activity decreases as blood Hg inc...
Other Authors: | , , |
---|---|
Format: | Thesis |
Language: | English |
Published: |
University of Northern British Columbia
2010
|
Subjects: | |
Online Access: | https://arcabc.ca/islandora/object/unbc%3A16074 https://doi.org/10.24124/2010/bpgub665 |
id |
ftarcabc:oai:arcabc.ca:unbc_16074 |
---|---|
record_format |
openpolar |
spelling |
ftarcabc:oai:arcabc.ca:unbc_16074 2024-06-02T08:01:18+00:00 The use of platelet monoamine oxidase-B as a biomarker for mercury neurotoxic effects among Inuit in Arctic Canada. Shaw, Alyssa (Author) Chan, Laurie (Thesis advisor) University of Northern British Columbia (Degree granting institution) 2010 electronic Number of pages in document: 67 https://arcabc.ca/islandora/object/unbc%3A16074 https://doi.org/10.24124/2010/bpgub665 English eng University of Northern British Columbia https://arcabc.ca/islandora/object/unbc%3A16074 uuid: aee569c7-33f6-4fac-a18c-742d2f6f110d bib-number: MR60854 isbn: 978-0-494-60854-8 https://doi.org/10.24124/2010/bpgub665 lac: TC-BPGUB-665 Copyright retained by the author. http://rightsstatements.org/vocab/InC/1.0/ Mercury in the body -- Canada Northern Inuit -- Health and hygiene -- Canada Arctic regions -- Environmental conditions QP535.H6 S33 2009 Text thesis 2010 ftarcabc https://doi.org/10.24124/2010/bpgub665 2024-05-06T00:30:44Z Mercury (Hg) is a widespread neurotoxin, therefore it is important to identify a biomarker of effect in populations that could be at risk of Hg exposure. Platelet monoamine oxidase (MAO) could be a biomarker since animal studies indicate that brain and platelet MAO activity decreases as blood Hg increases. This study examined the relationship between blood Hg and platelet MAO activities among Inuit in the Canadian Arctic. This study found an increase in platelet MAO activities as blood Hg levels increased, which could be due to the high selenium (Se) in the population. This study then examined the relationship between Hg and MAO activities in an established cell line (SH-SY5Y) and found that Hg treated cells had an increase in MAO activities, but no changes occurred in MAO-A mRNA levels. Discrepancies between animal studies and these in vitro results could be due to differences between cell lines and whole organisms. --P.ii. The original print copy of this thesis may be available here: http://wizard.unbc.ca/record=b1651425 Thesis Arctic inuit Arca (BC's Digital Treasures) Arctic Canada |
institution |
Open Polar |
collection |
Arca (BC's Digital Treasures) |
op_collection_id |
ftarcabc |
language |
English |
topic |
Mercury in the body -- Canada Northern Inuit -- Health and hygiene -- Canada Arctic regions -- Environmental conditions QP535.H6 S33 2009 |
spellingShingle |
Mercury in the body -- Canada Northern Inuit -- Health and hygiene -- Canada Arctic regions -- Environmental conditions QP535.H6 S33 2009 The use of platelet monoamine oxidase-B as a biomarker for mercury neurotoxic effects among Inuit in Arctic Canada. |
topic_facet |
Mercury in the body -- Canada Northern Inuit -- Health and hygiene -- Canada Arctic regions -- Environmental conditions QP535.H6 S33 2009 |
description |
Mercury (Hg) is a widespread neurotoxin, therefore it is important to identify a biomarker of effect in populations that could be at risk of Hg exposure. Platelet monoamine oxidase (MAO) could be a biomarker since animal studies indicate that brain and platelet MAO activity decreases as blood Hg increases. This study examined the relationship between blood Hg and platelet MAO activities among Inuit in the Canadian Arctic. This study found an increase in platelet MAO activities as blood Hg levels increased, which could be due to the high selenium (Se) in the population. This study then examined the relationship between Hg and MAO activities in an established cell line (SH-SY5Y) and found that Hg treated cells had an increase in MAO activities, but no changes occurred in MAO-A mRNA levels. Discrepancies between animal studies and these in vitro results could be due to differences between cell lines and whole organisms. --P.ii. The original print copy of this thesis may be available here: http://wizard.unbc.ca/record=b1651425 |
author2 |
Shaw, Alyssa (Author) Chan, Laurie (Thesis advisor) University of Northern British Columbia (Degree granting institution) |
format |
Thesis |
title |
The use of platelet monoamine oxidase-B as a biomarker for mercury neurotoxic effects among Inuit in Arctic Canada. |
title_short |
The use of platelet monoamine oxidase-B as a biomarker for mercury neurotoxic effects among Inuit in Arctic Canada. |
title_full |
The use of platelet monoamine oxidase-B as a biomarker for mercury neurotoxic effects among Inuit in Arctic Canada. |
title_fullStr |
The use of platelet monoamine oxidase-B as a biomarker for mercury neurotoxic effects among Inuit in Arctic Canada. |
title_full_unstemmed |
The use of platelet monoamine oxidase-B as a biomarker for mercury neurotoxic effects among Inuit in Arctic Canada. |
title_sort |
use of platelet monoamine oxidase-b as a biomarker for mercury neurotoxic effects among inuit in arctic canada. |
publisher |
University of Northern British Columbia |
publishDate |
2010 |
url |
https://arcabc.ca/islandora/object/unbc%3A16074 https://doi.org/10.24124/2010/bpgub665 |
geographic |
Arctic Canada |
geographic_facet |
Arctic Canada |
genre |
Arctic inuit |
genre_facet |
Arctic inuit |
op_relation |
https://arcabc.ca/islandora/object/unbc%3A16074 uuid: aee569c7-33f6-4fac-a18c-742d2f6f110d bib-number: MR60854 isbn: 978-0-494-60854-8 https://doi.org/10.24124/2010/bpgub665 lac: TC-BPGUB-665 |
op_rights |
Copyright retained by the author. http://rightsstatements.org/vocab/InC/1.0/ |
op_doi |
https://doi.org/10.24124/2010/bpgub665 |
_version_ |
1800745603855024128 |