Bioprospecting Antarctic microalgae as anticancer agent against PC-3 and AGS cell lines
Studies on pharmaceutical and medicine applications of cold adapted polar microalgae are very limited. In this study, it is aimed to evaluate the cytotoxic activity of polar microalgae extracts against different cancer cell lines. In this context, the cultivation of Chlorella variabilis YTU.ANTARCTI...
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2023
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ftaperta:oai:aperta.ulakbim.gov.tr:271798 2024-06-23T07:47:20+00:00 Bioprospecting Antarctic microalgae as anticancer agent against PC-3 and AGS cell lines Inan, Benan Mutlu, Betul Karaca, Guelcan Aysin Koc, Rabia Cakir Ozcimen, Didem 2023-01-01 https://aperta.ulakbim.gov.tr/record/271798 unknown https://aperta.ulakbim.gov.tr/record/271798 oai:aperta.ulakbim.gov.tr:271798 info:eu-repo/semantics/openAccess http://www.opendefinition.org/licenses/cc-by BIOCHEMICAL ENGINEERING JOURNAL 195 13 info:eu-repo/semantics/article publication-article 2023 ftaperta 2024-06-12T23:31:53Z Studies on pharmaceutical and medicine applications of cold adapted polar microalgae are very limited. In this study, it is aimed to evaluate the cytotoxic activity of polar microalgae extracts against different cancer cell lines. In this context, the cultivation of Chlorella variabilis YTU.ANTARCTIC.001 and Auxenochlorella pyrenoidosa OZCIMEN.001 were carried out and their oil extracts were encapsulated in nanoparticle to preserve its bioactive components against oxidation and to increase the penetration of the extract into the cancer cells. To investigate the anticancer effects of microalgae, cell culture studies were performed and then the extracts and nanoparticles were applied to the AGS and PC-3 cell lines via XTT method. In line with the study, it was observed that C. pyrenoidosa extracts showed higher cytotoxicity than C. variabilis against AGS and PC-3 cells. At 500 & mu;g/ml, AGS cells tested with C. variabilis showed a decrease down to 58 % and at the same concentration of C. pyrenoidosa, it was determined as 51 %. As for nanoparticle form, C. variabilis extracts exhibited higher cytotoxic activity and better anticancer properties. It was found that, these potential anticancer effects appeared to be largely concentration-dependent. Moreover, C. variabilis extract was determined as less effective on scratch closure than C. pyrenoidosa. In conclusion, the obtained data will pave the way to produce biotechnological drugs based on polar microalgae. Article in Journal/Newspaper Antarc* Antarctic Aperta - Türkiye Açık Arşiv Antarctic |
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Aperta - Türkiye Açık Arşiv |
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Studies on pharmaceutical and medicine applications of cold adapted polar microalgae are very limited. In this study, it is aimed to evaluate the cytotoxic activity of polar microalgae extracts against different cancer cell lines. In this context, the cultivation of Chlorella variabilis YTU.ANTARCTIC.001 and Auxenochlorella pyrenoidosa OZCIMEN.001 were carried out and their oil extracts were encapsulated in nanoparticle to preserve its bioactive components against oxidation and to increase the penetration of the extract into the cancer cells. To investigate the anticancer effects of microalgae, cell culture studies were performed and then the extracts and nanoparticles were applied to the AGS and PC-3 cell lines via XTT method. In line with the study, it was observed that C. pyrenoidosa extracts showed higher cytotoxicity than C. variabilis against AGS and PC-3 cells. At 500 & mu;g/ml, AGS cells tested with C. variabilis showed a decrease down to 58 % and at the same concentration of C. pyrenoidosa, it was determined as 51 %. As for nanoparticle form, C. variabilis extracts exhibited higher cytotoxic activity and better anticancer properties. It was found that, these potential anticancer effects appeared to be largely concentration-dependent. Moreover, C. variabilis extract was determined as less effective on scratch closure than C. pyrenoidosa. In conclusion, the obtained data will pave the way to produce biotechnological drugs based on polar microalgae. |
format |
Article in Journal/Newspaper |
author |
Inan, Benan Mutlu, Betul Karaca, Guelcan Aysin Koc, Rabia Cakir Ozcimen, Didem |
spellingShingle |
Inan, Benan Mutlu, Betul Karaca, Guelcan Aysin Koc, Rabia Cakir Ozcimen, Didem Bioprospecting Antarctic microalgae as anticancer agent against PC-3 and AGS cell lines |
author_facet |
Inan, Benan Mutlu, Betul Karaca, Guelcan Aysin Koc, Rabia Cakir Ozcimen, Didem |
author_sort |
Inan, Benan |
title |
Bioprospecting Antarctic microalgae as anticancer agent against PC-3 and AGS cell lines |
title_short |
Bioprospecting Antarctic microalgae as anticancer agent against PC-3 and AGS cell lines |
title_full |
Bioprospecting Antarctic microalgae as anticancer agent against PC-3 and AGS cell lines |
title_fullStr |
Bioprospecting Antarctic microalgae as anticancer agent against PC-3 and AGS cell lines |
title_full_unstemmed |
Bioprospecting Antarctic microalgae as anticancer agent against PC-3 and AGS cell lines |
title_sort |
bioprospecting antarctic microalgae as anticancer agent against pc-3 and ags cell lines |
publishDate |
2023 |
url |
https://aperta.ulakbim.gov.tr/record/271798 |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
BIOCHEMICAL ENGINEERING JOURNAL 195 13 |
op_relation |
https://aperta.ulakbim.gov.tr/record/271798 oai:aperta.ulakbim.gov.tr:271798 |
op_rights |
info:eu-repo/semantics/openAccess http://www.opendefinition.org/licenses/cc-by |
_version_ |
1802651428512071680 |