Development of the novel LDL-receptor targeted liposome formulation for cancer treatment

• Main Authors: Charbe, Nitin
• Other Authors: Pontificia Universidad Catolica De Chile
• Format: Report
• Language: unknown
• Published: 2023
• Subjects: Liposome LDL-receptor Anti-cancer; Quimica Organica; Magallanes; Valparaíso; Bío Bío; General Bernardo O'Higgins; Antártica
• Online Access: https://hdl.handle.net/10533/49139

1 In the proposed work, we planned to develop a novel liposomal paclitaxel formulation in PEGylated liposome conjugated with PCSK9 (PCSK9-PEGLip; PCSK9 conjugated Liposomes). Here we expected to combine the LDL-targeting properties of PCSK9 with the drug delivery properties of sterically stabilized...