Data from: The impact of long-term azithromycin on antibiotic resistance in HIV-associated chronic lung disease
External Organisations University of Cape Town; Biomedical Research and Training Institute Harare; London School of Hygiene and Tropical Medicine; Malawi-Liverpool-Wellcome Trust Clinical Research Programme; University College London; UiT The Arctic University of Norway Associated Persons Regina Esi...
Other Authors: | , |
---|---|
Format: | Dataset |
Language: | unknown |
Published: |
The University of Western Australia
|
Subjects: | |
Online Access: | https://researchdata.edu.au/data-from-the-lung-disease/1822458 https://doi.org/10.5061/dryad.5dv41ns71 |
id |
ftands:oai:ands.org.au::1822458 |
---|---|
record_format |
openpolar |
spelling |
ftands:oai:ands.org.au::1822458 2024-02-27T08:46:16+00:00 Data from: The impact of long-term azithromycin on antibiotic resistance in HIV-associated chronic lung disease Mark P. Nicol (Creator) Marshall Centre (isManagedBy) https://researchdata.edu.au/data-from-the-lung-disease/1822458 https://doi.org/10.5061/dryad.5dv41ns71 unknown The University of Western Australia https://researchdata.edu.au/data-from-the-lung-disease/1822458 50e2927d-ab31-472b-9a1c-0479064575a1 doi:10.5061/dryad.5dv41ns71 University of Western Australia FOS: Medical and health sciences nasopharyngeal swabs Africa chronic lung disease azithromycin sputum Haemophilus influenzae Streptococcus pneumoniae Antibiotic Malawi children antibiotic resistance Zimbabwe Moraxella catarrhalis HIV-AIDS Staphylococcus aureus dataset ftands https://doi.org/10.5061/dryad.5dv41ns71 2024-01-29T23:26:54Z External Organisations University of Cape Town; Biomedical Research and Training Institute Harare; London School of Hygiene and Tropical Medicine; Malawi-Liverpool-Wellcome Trust Clinical Research Programme; University College London; UiT The Arctic University of Norway Associated Persons Regina Esinam Abotsi (Creator); Grace McHugh (Creator); Victoria Simms (Creator); Andrea M. Rehman (Creator); Charmaine Barthus (Creator); Lucky Gift Ngwira (Creator); Brenda Anna Kwambana-Adams (Creator); Robert S Heyderman (Creator); Jon Ø Odland (Creator); Rashida A Ferrand (Creator); Felix S. Dube (Creator) Background: Selection for resistance to azithromycin (AZM) and other antibiotics such as tetracyclines and lincosamides remains a concern with long-term AZM use for treatment of chronic lung diseases (CLD). We investigated the impact of 48 weeks of AZM on the carriage and antibiotic resistance of common respiratory bacteria among children with HIV-associated CLD. Methods: Nasopharyngeal (NP) swabs and sputa were collected at baseline, 48 and 72 weeks from participants with HIV-associated CLD randomised to receive weekly AZM or placebo for 48 weeks and followed post-intervention until 72 weeks. The primary outcomes were prevalence and antibiotic resistance of Streptococcus pneumoniae (SP), Staphylococcus aureus (SA), Haemophilus influenzae (HI), and Moraxella catarrhalis (MC) at these timepoints. Mixed-effects logistic regression and Fisher's exact test were used to compare carriage and resistance respectively. Results: Of 347 (174 AZM, 173 placebo) participants (median age 15 years [IQR =13–18], females 49%),NP carriage was significantly lower in the AZM (n=159) compared to placebo (n=153) arm for SP (18% vs 41%, p<0.001), HI (7% vs 16%, p=0.01), and MC (4% vs 11%, p=0.02); SP resistance to AZM (62% [18/29] vs 13%[8/63], p<0.0001) or tetracycline (60%[18/29] vs 21%[13/63], p<0.0001) were higher in the AZM arm. Carriage of SA resistant to AZM (91% [31/34] vs 3% [1/31], p<0.0001), tetracycline (35% [12/34] ... Dataset Arctic University of Norway UiT The Arctic University of Norway Research Data Australia (Australian National Data Service - ANDS) Arctic Norway Regina ENVELOPE(154.846,154.846,64.939,64.939) |
institution |
Open Polar |
collection |
Research Data Australia (Australian National Data Service - ANDS) |
op_collection_id |
ftands |
language |
unknown |
topic |
FOS: Medical and health sciences nasopharyngeal swabs Africa chronic lung disease azithromycin sputum Haemophilus influenzae Streptococcus pneumoniae Antibiotic Malawi children antibiotic resistance Zimbabwe Moraxella catarrhalis HIV-AIDS Staphylococcus aureus |
spellingShingle |
FOS: Medical and health sciences nasopharyngeal swabs Africa chronic lung disease azithromycin sputum Haemophilus influenzae Streptococcus pneumoniae Antibiotic Malawi children antibiotic resistance Zimbabwe Moraxella catarrhalis HIV-AIDS Staphylococcus aureus Data from: The impact of long-term azithromycin on antibiotic resistance in HIV-associated chronic lung disease |
topic_facet |
FOS: Medical and health sciences nasopharyngeal swabs Africa chronic lung disease azithromycin sputum Haemophilus influenzae Streptococcus pneumoniae Antibiotic Malawi children antibiotic resistance Zimbabwe Moraxella catarrhalis HIV-AIDS Staphylococcus aureus |
description |
External Organisations University of Cape Town; Biomedical Research and Training Institute Harare; London School of Hygiene and Tropical Medicine; Malawi-Liverpool-Wellcome Trust Clinical Research Programme; University College London; UiT The Arctic University of Norway Associated Persons Regina Esinam Abotsi (Creator); Grace McHugh (Creator); Victoria Simms (Creator); Andrea M. Rehman (Creator); Charmaine Barthus (Creator); Lucky Gift Ngwira (Creator); Brenda Anna Kwambana-Adams (Creator); Robert S Heyderman (Creator); Jon Ø Odland (Creator); Rashida A Ferrand (Creator); Felix S. Dube (Creator) Background: Selection for resistance to azithromycin (AZM) and other antibiotics such as tetracyclines and lincosamides remains a concern with long-term AZM use for treatment of chronic lung diseases (CLD). We investigated the impact of 48 weeks of AZM on the carriage and antibiotic resistance of common respiratory bacteria among children with HIV-associated CLD. Methods: Nasopharyngeal (NP) swabs and sputa were collected at baseline, 48 and 72 weeks from participants with HIV-associated CLD randomised to receive weekly AZM or placebo for 48 weeks and followed post-intervention until 72 weeks. The primary outcomes were prevalence and antibiotic resistance of Streptococcus pneumoniae (SP), Staphylococcus aureus (SA), Haemophilus influenzae (HI), and Moraxella catarrhalis (MC) at these timepoints. Mixed-effects logistic regression and Fisher's exact test were used to compare carriage and resistance respectively. Results: Of 347 (174 AZM, 173 placebo) participants (median age 15 years [IQR =13–18], females 49%),NP carriage was significantly lower in the AZM (n=159) compared to placebo (n=153) arm for SP (18% vs 41%, p<0.001), HI (7% vs 16%, p=0.01), and MC (4% vs 11%, p=0.02); SP resistance to AZM (62% [18/29] vs 13%[8/63], p<0.0001) or tetracycline (60%[18/29] vs 21%[13/63], p<0.0001) were higher in the AZM arm. Carriage of SA resistant to AZM (91% [31/34] vs 3% [1/31], p<0.0001), tetracycline (35% [12/34] ... |
author2 |
Mark P. Nicol (Creator) Marshall Centre (isManagedBy) |
format |
Dataset |
title |
Data from: The impact of long-term azithromycin on antibiotic resistance in HIV-associated chronic lung disease |
title_short |
Data from: The impact of long-term azithromycin on antibiotic resistance in HIV-associated chronic lung disease |
title_full |
Data from: The impact of long-term azithromycin on antibiotic resistance in HIV-associated chronic lung disease |
title_fullStr |
Data from: The impact of long-term azithromycin on antibiotic resistance in HIV-associated chronic lung disease |
title_full_unstemmed |
Data from: The impact of long-term azithromycin on antibiotic resistance in HIV-associated chronic lung disease |
title_sort |
data from: the impact of long-term azithromycin on antibiotic resistance in hiv-associated chronic lung disease |
publisher |
The University of Western Australia |
url |
https://researchdata.edu.au/data-from-the-lung-disease/1822458 https://doi.org/10.5061/dryad.5dv41ns71 |
long_lat |
ENVELOPE(154.846,154.846,64.939,64.939) |
geographic |
Arctic Norway Regina |
geographic_facet |
Arctic Norway Regina |
genre |
Arctic University of Norway UiT The Arctic University of Norway |
genre_facet |
Arctic University of Norway UiT The Arctic University of Norway |
op_source |
University of Western Australia |
op_relation |
https://researchdata.edu.au/data-from-the-lung-disease/1822458 50e2927d-ab31-472b-9a1c-0479064575a1 doi:10.5061/dryad.5dv41ns71 |
op_doi |
https://doi.org/10.5061/dryad.5dv41ns71 |
_version_ |
1792055724130435072 |