A mechanistic investigation on anticholinesterase and antioxidant effects of rose (Rosa damascena Mill.)
WOS: 000323239400061 In the current study, neuroprotective effect of the essential oil and aromatic waters of rose was investigated by in vitro and in silico methods. The samples were tested for their inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Since oxi...
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Online Access: | https://hdl.handle.net/11421/12821 https://doi.org/10.1016/j.foodres.2013.05.031 |
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ftanadoluuniv:oai:earsiv.anadolu.edu.tr:11421/12821 2023-05-15T18:33:56+02:00 A mechanistic investigation on anticholinesterase and antioxidant effects of rose (Rosa damascena Mill.) Şenol, Fatma Sezer Orhan, İlkay Erdoğan Kürkçüoğlu, Mine Khan, Mahmud Tareq Hassan Altıntaş, Ayten Şener, Bilge Başer, K. Hüsnü Can Anadolu Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı Kürkçüoğlu, Mine Başer, K. Hüsnü Can 2013 application/pdf https://hdl.handle.net/11421/12821 https://doi.org/10.1016/j.foodres.2013.05.031 eng eng Elsevier Science BV 10.1016/j.foodres.2013.05.031 Food Research International Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı 0963-9969 https://dx.doi.org/10.1016/j.foodres.2013.05.031 https://hdl.handle.net/11421/12821 53 1 502 509 info:eu-repo/semantics/closedAccess Rose Cholinesterase Inhibition Antioxidant Activity Molecular Docking Phenylethyl Alcohol article 2013 ftanadoluuniv https://doi.org/10.1016/j.foodres.2013.05.031 2020-10-21T11:15:41Z WOS: 000323239400061 In the current study, neuroprotective effect of the essential oil and aromatic waters of rose was investigated by in vitro and in silico methods. The samples were tested for their inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Since oxidative damage is associated with neurodegeneration, antioxidant activity of the samples was determined by DPPH radical scavenging, metal-chelation, and ferric-reducing antioxidant power (FRAP) assays. Their chemical composition was elucidated by GC-MS. Anti-cholinesterase effects of the main components (citronellol, geraniol, nerol, and phenylethyl alcohol) were also examined. The rose oil showed a noteworthy inhibition against AChE (60.86 +/- 1.99%) and BChE (51.08 +/- 1.70%) at 1000 mu g/mL and low activity in DPPH radical scavenging and FRAP tests. Phenylethyl alcohol exerted higher cholinesterase inhibition than other components and applied further to molecular docking simulations. Docking and binding energies supporting experimental results show that the compound is more selective towards BChE than AChE Scientific and Technological Research Council of Turkey (TUBITAK) F.S. Senol expresses her sincere gratefulness to the Scientific and Technological Research Council of Turkey (TUBITAK) for the scholarship provided for Ph.D. program. The authors also would like to thank IFF (International Flavors & Fragrances Inc., NY, USA) for providing the reference samples of (-)-beta-citronellol, (+)-beta-citronellol, geraniol, nerol, and phenylethyl alcohol used in this study as a courtesy. M.T.H. Khan is grateful to Prof. Ingebrigt Sylte (Department of Medical Biology, Faculty of Health Science, University of Tromso, Norway) for the access of the license of ICM-Pro version. Article in Journal/Newspaper Tromso University of Tromso Anadolu University Institutional Repository Norway Tromso ENVELOPE(16.546,16.546,68.801,68.801) Food Research International 53 1 502 509 |
institution |
Open Polar |
collection |
Anadolu University Institutional Repository |
op_collection_id |
ftanadoluuniv |
language |
English |
topic |
Rose Cholinesterase Inhibition Antioxidant Activity Molecular Docking Phenylethyl Alcohol |
spellingShingle |
Rose Cholinesterase Inhibition Antioxidant Activity Molecular Docking Phenylethyl Alcohol Şenol, Fatma Sezer Orhan, İlkay Erdoğan Kürkçüoğlu, Mine Khan, Mahmud Tareq Hassan Altıntaş, Ayten Şener, Bilge Başer, K. Hüsnü Can A mechanistic investigation on anticholinesterase and antioxidant effects of rose (Rosa damascena Mill.) |
topic_facet |
Rose Cholinesterase Inhibition Antioxidant Activity Molecular Docking Phenylethyl Alcohol |
description |
WOS: 000323239400061 In the current study, neuroprotective effect of the essential oil and aromatic waters of rose was investigated by in vitro and in silico methods. The samples were tested for their inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Since oxidative damage is associated with neurodegeneration, antioxidant activity of the samples was determined by DPPH radical scavenging, metal-chelation, and ferric-reducing antioxidant power (FRAP) assays. Their chemical composition was elucidated by GC-MS. Anti-cholinesterase effects of the main components (citronellol, geraniol, nerol, and phenylethyl alcohol) were also examined. The rose oil showed a noteworthy inhibition against AChE (60.86 +/- 1.99%) and BChE (51.08 +/- 1.70%) at 1000 mu g/mL and low activity in DPPH radical scavenging and FRAP tests. Phenylethyl alcohol exerted higher cholinesterase inhibition than other components and applied further to molecular docking simulations. Docking and binding energies supporting experimental results show that the compound is more selective towards BChE than AChE Scientific and Technological Research Council of Turkey (TUBITAK) F.S. Senol expresses her sincere gratefulness to the Scientific and Technological Research Council of Turkey (TUBITAK) for the scholarship provided for Ph.D. program. The authors also would like to thank IFF (International Flavors & Fragrances Inc., NY, USA) for providing the reference samples of (-)-beta-citronellol, (+)-beta-citronellol, geraniol, nerol, and phenylethyl alcohol used in this study as a courtesy. M.T.H. Khan is grateful to Prof. Ingebrigt Sylte (Department of Medical Biology, Faculty of Health Science, University of Tromso, Norway) for the access of the license of ICM-Pro version. |
author2 |
Anadolu Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı Kürkçüoğlu, Mine Başer, K. Hüsnü Can |
format |
Article in Journal/Newspaper |
author |
Şenol, Fatma Sezer Orhan, İlkay Erdoğan Kürkçüoğlu, Mine Khan, Mahmud Tareq Hassan Altıntaş, Ayten Şener, Bilge Başer, K. Hüsnü Can |
author_facet |
Şenol, Fatma Sezer Orhan, İlkay Erdoğan Kürkçüoğlu, Mine Khan, Mahmud Tareq Hassan Altıntaş, Ayten Şener, Bilge Başer, K. Hüsnü Can |
author_sort |
Şenol, Fatma Sezer |
title |
A mechanistic investigation on anticholinesterase and antioxidant effects of rose (Rosa damascena Mill.) |
title_short |
A mechanistic investigation on anticholinesterase and antioxidant effects of rose (Rosa damascena Mill.) |
title_full |
A mechanistic investigation on anticholinesterase and antioxidant effects of rose (Rosa damascena Mill.) |
title_fullStr |
A mechanistic investigation on anticholinesterase and antioxidant effects of rose (Rosa damascena Mill.) |
title_full_unstemmed |
A mechanistic investigation on anticholinesterase and antioxidant effects of rose (Rosa damascena Mill.) |
title_sort |
mechanistic investigation on anticholinesterase and antioxidant effects of rose (rosa damascena mill.) |
publisher |
Elsevier Science BV |
publishDate |
2013 |
url |
https://hdl.handle.net/11421/12821 https://doi.org/10.1016/j.foodres.2013.05.031 |
long_lat |
ENVELOPE(16.546,16.546,68.801,68.801) |
geographic |
Norway Tromso |
geographic_facet |
Norway Tromso |
genre |
Tromso University of Tromso |
genre_facet |
Tromso University of Tromso |
op_relation |
10.1016/j.foodres.2013.05.031 Food Research International Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı 0963-9969 https://dx.doi.org/10.1016/j.foodres.2013.05.031 https://hdl.handle.net/11421/12821 53 1 502 509 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/j.foodres.2013.05.031 |
container_title |
Food Research International |
container_volume |
53 |
container_issue |
1 |
container_start_page |
502 |
op_container_end_page |
509 |
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1766218567997456384 |