Physical inactivity and platelet function in humans and brown bears:A comparative study
Physical inactivity increases the risk of thromboembolism. However, good standardized human models on inactivity are in short supply and experimental models are few. Our objective was to investigate how standardized bed rest affects platelet aggregation in humans and to investigate if aggregation is...
Published in: | Platelets |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2018
|
Subjects: | |
Online Access: | https://vbn.aau.dk/da/publications/f7d36cda-a45f-4822-bc0e-1fbd2a452ddb https://doi.org/10.1080/09537104.2017.1336530 http://www.scopus.com/inward/record.url?scp=85026519068&partnerID=8YFLogxK |
id |
ftalborgunivpubl:oai:pure.atira.dk:publications/f7d36cda-a45f-4822-bc0e-1fbd2a452ddb |
---|---|
record_format |
openpolar |
spelling |
ftalborgunivpubl:oai:pure.atira.dk:publications/f7d36cda-a45f-4822-bc0e-1fbd2a452ddb 2024-09-15T18:40:14+00:00 Physical inactivity and platelet function in humans and brown bears:A comparative study Arinell, K. Blanc, S. Welinder, K. G. Støen, O. G. Evans, A. L. Fröbert, O. 2018 https://vbn.aau.dk/da/publications/f7d36cda-a45f-4822-bc0e-1fbd2a452ddb https://doi.org/10.1080/09537104.2017.1336530 http://www.scopus.com/inward/record.url?scp=85026519068&partnerID=8YFLogxK eng eng https://vbn.aau.dk/da/publications/f7d36cda-a45f-4822-bc0e-1fbd2a452ddb info:eu-repo/semantics/closedAccess Arinell , K , Blanc , S , Welinder , K G , Støen , O G , Evans , A L & Fröbert , O 2018 , ' Physical inactivity and platelet function in humans and brown bears : A comparative study ' , Platelets , vol. 29 , no. 1 , pp. 87-90 . https://doi.org/10.1080/09537104.2017.1336530 Immobilization Platelet aggregation Platelets Thrombosis article 2018 ftalborgunivpubl https://doi.org/10.1080/09537104.2017.1336530 2024-08-22T00:15:02Z Physical inactivity increases the risk of thromboembolism. However, good standardized human models on inactivity are in short supply and experimental models are few. Our objective was to investigate how standardized bed rest affects platelet aggregation in humans and to investigate if aggregation is altered in a translational model system – the hibernating brown bear (Ursus arctos). We collected blood from (1) healthy male volunteers participating in a 21-day bed rest study in head-down tilt position (−6°) 24 h a day; (2) free-ranging brown bears captured during winter hibernation and again during active state in summer. We analyzed platelet function using multiple electrode platelet aggregometry. In total, 9 healthy male volunteers (age 31.0 ± 6.4 years) and 13 brown bears (7 females and 6 males, age 2.8 ± 0.6 years) were included. In hibernating bears adenosine diphosphate, arachidonic acid, thrombin receptor activating peptide, and collagen impedance aggregometry tests were all halved compared to summer active state. In human volunteers no statistically significant changes were found between baseline and the end of bed rest. In human male volunteers 3 weeks of bed rest did not affect platelet function. In hibernating brown bears platelet aggregation was halved compared to summer and we hypothesize that this is a protective measure to avoid formation of thrombi under periods of low blood flow. Article in Journal/Newspaper Ursus arctos Aalborg University's Research Portal Platelets 29 1 87 90 |
institution |
Open Polar |
collection |
Aalborg University's Research Portal |
op_collection_id |
ftalborgunivpubl |
language |
English |
topic |
Immobilization Platelet aggregation Platelets Thrombosis |
spellingShingle |
Immobilization Platelet aggregation Platelets Thrombosis Arinell, K. Blanc, S. Welinder, K. G. Støen, O. G. Evans, A. L. Fröbert, O. Physical inactivity and platelet function in humans and brown bears:A comparative study |
topic_facet |
Immobilization Platelet aggregation Platelets Thrombosis |
description |
Physical inactivity increases the risk of thromboembolism. However, good standardized human models on inactivity are in short supply and experimental models are few. Our objective was to investigate how standardized bed rest affects platelet aggregation in humans and to investigate if aggregation is altered in a translational model system – the hibernating brown bear (Ursus arctos). We collected blood from (1) healthy male volunteers participating in a 21-day bed rest study in head-down tilt position (−6°) 24 h a day; (2) free-ranging brown bears captured during winter hibernation and again during active state in summer. We analyzed platelet function using multiple electrode platelet aggregometry. In total, 9 healthy male volunteers (age 31.0 ± 6.4 years) and 13 brown bears (7 females and 6 males, age 2.8 ± 0.6 years) were included. In hibernating bears adenosine diphosphate, arachidonic acid, thrombin receptor activating peptide, and collagen impedance aggregometry tests were all halved compared to summer active state. In human volunteers no statistically significant changes were found between baseline and the end of bed rest. In human male volunteers 3 weeks of bed rest did not affect platelet function. In hibernating brown bears platelet aggregation was halved compared to summer and we hypothesize that this is a protective measure to avoid formation of thrombi under periods of low blood flow. |
format |
Article in Journal/Newspaper |
author |
Arinell, K. Blanc, S. Welinder, K. G. Støen, O. G. Evans, A. L. Fröbert, O. |
author_facet |
Arinell, K. Blanc, S. Welinder, K. G. Støen, O. G. Evans, A. L. Fröbert, O. |
author_sort |
Arinell, K. |
title |
Physical inactivity and platelet function in humans and brown bears:A comparative study |
title_short |
Physical inactivity and platelet function in humans and brown bears:A comparative study |
title_full |
Physical inactivity and platelet function in humans and brown bears:A comparative study |
title_fullStr |
Physical inactivity and platelet function in humans and brown bears:A comparative study |
title_full_unstemmed |
Physical inactivity and platelet function in humans and brown bears:A comparative study |
title_sort |
physical inactivity and platelet function in humans and brown bears:a comparative study |
publishDate |
2018 |
url |
https://vbn.aau.dk/da/publications/f7d36cda-a45f-4822-bc0e-1fbd2a452ddb https://doi.org/10.1080/09537104.2017.1336530 http://www.scopus.com/inward/record.url?scp=85026519068&partnerID=8YFLogxK |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_source |
Arinell , K , Blanc , S , Welinder , K G , Støen , O G , Evans , A L & Fröbert , O 2018 , ' Physical inactivity and platelet function in humans and brown bears : A comparative study ' , Platelets , vol. 29 , no. 1 , pp. 87-90 . https://doi.org/10.1080/09537104.2017.1336530 |
op_relation |
https://vbn.aau.dk/da/publications/f7d36cda-a45f-4822-bc0e-1fbd2a452ddb |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1080/09537104.2017.1336530 |
container_title |
Platelets |
container_volume |
29 |
container_issue |
1 |
container_start_page |
87 |
op_container_end_page |
90 |
_version_ |
1810484548473978880 |