Ethnicity is important for creatinine excretion among Inuit and Caucasians in Greenland
Background. Human nutrition, contamination and renal function are commonly assessed by the analysis of urine. A complete 24-hour urine sample is the ideal but it is inconvenient and unreliable. Thus, spot urine sampling with creatinine adjustment is widely used. Stratification for age and gender is...
Published in: | Scandinavian Journal of Clinical and Laboratory Investigation |
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Online Access: | https://vbn.aau.dk/da/publications/7d40f698-7ea5-4da3-9a94-d18620298a29 https://doi.org/10.3109/00365513.2014.965737 |
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ftalborgunivpubl:oai:pure.atira.dk:publications/7d40f698-7ea5-4da3-9a94-d18620298a29 2024-05-19T07:41:17+00:00 Ethnicity is important for creatinine excretion among Inuit and Caucasians in Greenland Andersen, Stig Dehnfeld, Marie Laurberg, Peter 2015-10-27 https://vbn.aau.dk/da/publications/7d40f698-7ea5-4da3-9a94-d18620298a29 https://doi.org/10.3109/00365513.2014.965737 eng eng https://vbn.aau.dk/da/publications/7d40f698-7ea5-4da3-9a94-d18620298a29 info:eu-repo/semantics/closedAccess Andersen , S , Dehnfeld , M & Laurberg , P 2015 , ' Ethnicity is important for creatinine excretion among Inuit and Caucasians in Greenland ' , Scandinavian Journal of Clinical & Laboratory Investigation , vol. 75 , no. 1 , pp. 44-50 . https://doi.org/10.3109/00365513.2014.965737 article 2015 ftalborgunivpubl https://doi.org/10.3109/00365513.2014.965737 2024-04-22T00:54:02Z Background. Human nutrition, contamination and renal function are commonly assessed by the analysis of urine. A complete 24-hour urine sample is the ideal but it is inconvenient and unreliable. Thus, spot urine sampling with creatinine adjustment is widely used. Stratification for age and gender is recommended. Still, ethnicity may influence creatinine excretion. Methods. We collected 104 24-h urine samples among Inuit and non-Inuit living in Greenland. Completeness of sampling was checked by using para-amino benzoic acid (PABA) that also allowed for compensation of creatinine excretion when sampling was incomplete. We measured creatinine using the Jaffe method and PABA by the HPLC method. Results. Participants were recruited from the capital city, a major town and a settlement (n = 36/48/20). They were aged 30-69 years with 78 Inuit and 26 non-Inuit. Inuit were smaller than non-Inuit (Caucasians): height, 163 vs. 177 cm, p < 0.001; weight, 71 vs. 84 kg, p = 0.001 with similar BMI. Creatinine excretion was lower in Inuit compared to non-Inuit (men, 1344/1807 mg/24 h; women 894/1259 mg/24 h; p = 0.002; 0.02). It was influenced by age (p < 0.001), gender (p < 0.001), weight (p = 0.001) and ethnicity (p = 0.030) while not by the intake of the protein-rich Inuit diet in the adjusted analysis. Creatinine excretion was described by: Inuit men, 1925 mg - (13.1 × age); Inuit women, 1701 mg - (17.0 × age). Conclusion. Inuit and Caucasians have different creatinine excretion. It is recommended to stratify by ethnicity in addition to adjustment for age and gender when using creatinine correction of spot urine samples. Article in Journal/Newspaper Greenland inuit Aalborg University's Research Portal Scandinavian Journal of Clinical and Laboratory Investigation 75 1 44 50 |
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Open Polar |
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Aalborg University's Research Portal |
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ftalborgunivpubl |
language |
English |
description |
Background. Human nutrition, contamination and renal function are commonly assessed by the analysis of urine. A complete 24-hour urine sample is the ideal but it is inconvenient and unreliable. Thus, spot urine sampling with creatinine adjustment is widely used. Stratification for age and gender is recommended. Still, ethnicity may influence creatinine excretion. Methods. We collected 104 24-h urine samples among Inuit and non-Inuit living in Greenland. Completeness of sampling was checked by using para-amino benzoic acid (PABA) that also allowed for compensation of creatinine excretion when sampling was incomplete. We measured creatinine using the Jaffe method and PABA by the HPLC method. Results. Participants were recruited from the capital city, a major town and a settlement (n = 36/48/20). They were aged 30-69 years with 78 Inuit and 26 non-Inuit. Inuit were smaller than non-Inuit (Caucasians): height, 163 vs. 177 cm, p < 0.001; weight, 71 vs. 84 kg, p = 0.001 with similar BMI. Creatinine excretion was lower in Inuit compared to non-Inuit (men, 1344/1807 mg/24 h; women 894/1259 mg/24 h; p = 0.002; 0.02). It was influenced by age (p < 0.001), gender (p < 0.001), weight (p = 0.001) and ethnicity (p = 0.030) while not by the intake of the protein-rich Inuit diet in the adjusted analysis. Creatinine excretion was described by: Inuit men, 1925 mg - (13.1 × age); Inuit women, 1701 mg - (17.0 × age). Conclusion. Inuit and Caucasians have different creatinine excretion. It is recommended to stratify by ethnicity in addition to adjustment for age and gender when using creatinine correction of spot urine samples. |
format |
Article in Journal/Newspaper |
author |
Andersen, Stig Dehnfeld, Marie Laurberg, Peter |
spellingShingle |
Andersen, Stig Dehnfeld, Marie Laurberg, Peter Ethnicity is important for creatinine excretion among Inuit and Caucasians in Greenland |
author_facet |
Andersen, Stig Dehnfeld, Marie Laurberg, Peter |
author_sort |
Andersen, Stig |
title |
Ethnicity is important for creatinine excretion among Inuit and Caucasians in Greenland |
title_short |
Ethnicity is important for creatinine excretion among Inuit and Caucasians in Greenland |
title_full |
Ethnicity is important for creatinine excretion among Inuit and Caucasians in Greenland |
title_fullStr |
Ethnicity is important for creatinine excretion among Inuit and Caucasians in Greenland |
title_full_unstemmed |
Ethnicity is important for creatinine excretion among Inuit and Caucasians in Greenland |
title_sort |
ethnicity is important for creatinine excretion among inuit and caucasians in greenland |
publishDate |
2015 |
url |
https://vbn.aau.dk/da/publications/7d40f698-7ea5-4da3-9a94-d18620298a29 https://doi.org/10.3109/00365513.2014.965737 |
genre |
Greenland inuit |
genre_facet |
Greenland inuit |
op_source |
Andersen , S , Dehnfeld , M & Laurberg , P 2015 , ' Ethnicity is important for creatinine excretion among Inuit and Caucasians in Greenland ' , Scandinavian Journal of Clinical & Laboratory Investigation , vol. 75 , no. 1 , pp. 44-50 . https://doi.org/10.3109/00365513.2014.965737 |
op_relation |
https://vbn.aau.dk/da/publications/7d40f698-7ea5-4da3-9a94-d18620298a29 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.3109/00365513.2014.965737 |
container_title |
Scandinavian Journal of Clinical and Laboratory Investigation |
container_volume |
75 |
container_issue |
1 |
container_start_page |
44 |
op_container_end_page |
50 |
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1799480875305402368 |