Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe:Results From the BiomarCaRE Consortium
Objectives: This study investigates differences between women and men in heart failure (HF) risk and mortality. Background: Sex differences in HF epidemiology are insufficiently understood. Methods: In 78,657 individuals (median 49.5 years of age; age range 24.1 to 98.7 years; 51.7% women) from comm...
Published in: | JACC: Heart Failure |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
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Online Access: | https://vbn.aau.dk/da/publications/63638538-310a-4bca-9b42-917b0bbac43a https://doi.org/10.1016/j.jchf.2018.08.008 http://www.scopus.com/inward/record.url?scp=85061563131&partnerID=8YFLogxK https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061563131&doi=10.1016%2fj.jchf.2018.08.008&partnerID=40&md5=a4e7b725649906bd82cfefe9b718e808 |
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ftalborgunivpubl:oai:pure.atira.dk:publications/63638538-310a-4bca-9b42-917b0bbac43a 2024-10-13T14:09:51+00:00 Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe:Results From the BiomarCaRE Consortium Magnussen, C. Niiranen, T.J. Ojeda, F.M. Gianfagna, F. Blankenberg, S. Vartiainen, E. Sans, S. Pasterkamp, G. Hughes, M. Costanzo, S. Donati, M.B. Jousilahti, P. Linneberg, A. Palosaari, T. de Gaetano, G. Bobak, M. den Ruijter, H.M. Jørgensen, T. Söderberg, S. Kuulasmaa, K. Zeller, T. Iacoviello, L. Salomaa, V. Schnabel, R.B. 2019-03-01 https://vbn.aau.dk/da/publications/63638538-310a-4bca-9b42-917b0bbac43a https://doi.org/10.1016/j.jchf.2018.08.008 http://www.scopus.com/inward/record.url?scp=85061563131&partnerID=8YFLogxK https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061563131&doi=10.1016%2fj.jchf.2018.08.008&partnerID=40&md5=a4e7b725649906bd82cfefe9b718e808 eng eng https://vbn.aau.dk/da/publications/63638538-310a-4bca-9b42-917b0bbac43a info:eu-repo/semantics/closedAccess Magnussen , C , Niiranen , T J , Ojeda , F M , Gianfagna , F , Blankenberg , S , Vartiainen , E , Sans , S , Pasterkamp , G , Hughes , M , Costanzo , S , Donati , M B , Jousilahti , P , Linneberg , A , Palosaari , T , de Gaetano , G , Bobak , M , den Ruijter , H M , Jørgensen , T , Söderberg , S , Kuulasmaa , K , Zeller , T , Iacoviello , L , Salomaa , V , Schnabel , R B & BiomarCaRE Consortium 2019 , ' Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe : Results From the BiomarCaRE Consortium ' , J A C C: Heart Failure , vol. 7 , no. 3 , pp. 204-213 . https://doi.org/10.1016/j.jchf.2018.08.008 biomarkers cohort epidemiology heart failure mortality sex article 2019 ftalborgunivpubl https://doi.org/10.1016/j.jchf.2018.08.008 2024-09-19T00:52:41Z Objectives: This study investigates differences between women and men in heart failure (HF) risk and mortality. Background: Sex differences in HF epidemiology are insufficiently understood. Methods: In 78,657 individuals (median 49.5 years of age; age range 24.1 to 98.7 years; 51.7% women) from community-based European studies (FINRISK, DanMONICA, Moli-sani, Northern Sweden) of the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium, the association between incident HF and mortality, the relationship of cardiovascular risk factors, prevalent cardiovascular diseases, biomarkers (C-reactive protein [CRP]; N-terminal pro–B-type natriuretic peptide [NT-proBNP]) with incident HF, and their attributable risks were tested in women vs. men. Results: Over a median follow-up of 12.7 years, fewer HF cases were observed in women (n = 2,399 [5.9%]) than in men (n = 2,771 [7.3%]). HF incidence increased markedly after 60 years of age, initially with a more rapid increase in men, whereas incidence in women exceeded that of men after 85 years of age. HF onset substantially increased mortality risk in both sexes. Multivariable-adjusted Cox models showed the following sex differences for the association with incident HF: systolic blood pressure hazard ratio (HR) according to SD in women of 1.09 (95% confidence interval [CI]: 1.05 to 1.14) versus HR of 1.19 (95% CI: 1.14 to 1.24) in men; heart rate HR of 0.98 (95% CI: 0.93 to 1.03) in women versus HR of 1.09 (95% CI: 1.04 to 1.13) in men; CRP HR of 1.10 (95% CI: 1.00 to 1.20) in women versus HR of 1.32 (95% CI: 1.24 to 1.41) in men; and NT-proBNP HR of 1.54 (95% CI: 1.37 to 1.74) in women versus HR of 1.89 (95% CI: 1.75 to 2.05) in men. Population-attributable risk of all risk factors combined was 59.0% in women and 62.9% in men. Conclusions: Women had a lower risk for HF than men. Sex differences were seen for systolic blood pressure, heart rate, CRP, and NT-proBNP, with a lower HF risk in women. Article in Journal/Newspaper Northern Sweden Aalborg University's Research Portal Moli ENVELOPE(19.182,19.182,69.227,69.227) JACC: Heart Failure 7 3 204 213 |
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Open Polar |
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Aalborg University's Research Portal |
op_collection_id |
ftalborgunivpubl |
language |
English |
topic |
biomarkers cohort epidemiology heart failure mortality sex |
spellingShingle |
biomarkers cohort epidemiology heart failure mortality sex Magnussen, C. Niiranen, T.J. Ojeda, F.M. Gianfagna, F. Blankenberg, S. Vartiainen, E. Sans, S. Pasterkamp, G. Hughes, M. Costanzo, S. Donati, M.B. Jousilahti, P. Linneberg, A. Palosaari, T. de Gaetano, G. Bobak, M. den Ruijter, H.M. Jørgensen, T. Söderberg, S. Kuulasmaa, K. Zeller, T. Iacoviello, L. Salomaa, V. Schnabel, R.B. Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe:Results From the BiomarCaRE Consortium |
topic_facet |
biomarkers cohort epidemiology heart failure mortality sex |
description |
Objectives: This study investigates differences between women and men in heart failure (HF) risk and mortality. Background: Sex differences in HF epidemiology are insufficiently understood. Methods: In 78,657 individuals (median 49.5 years of age; age range 24.1 to 98.7 years; 51.7% women) from community-based European studies (FINRISK, DanMONICA, Moli-sani, Northern Sweden) of the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium, the association between incident HF and mortality, the relationship of cardiovascular risk factors, prevalent cardiovascular diseases, biomarkers (C-reactive protein [CRP]; N-terminal pro–B-type natriuretic peptide [NT-proBNP]) with incident HF, and their attributable risks were tested in women vs. men. Results: Over a median follow-up of 12.7 years, fewer HF cases were observed in women (n = 2,399 [5.9%]) than in men (n = 2,771 [7.3%]). HF incidence increased markedly after 60 years of age, initially with a more rapid increase in men, whereas incidence in women exceeded that of men after 85 years of age. HF onset substantially increased mortality risk in both sexes. Multivariable-adjusted Cox models showed the following sex differences for the association with incident HF: systolic blood pressure hazard ratio (HR) according to SD in women of 1.09 (95% confidence interval [CI]: 1.05 to 1.14) versus HR of 1.19 (95% CI: 1.14 to 1.24) in men; heart rate HR of 0.98 (95% CI: 0.93 to 1.03) in women versus HR of 1.09 (95% CI: 1.04 to 1.13) in men; CRP HR of 1.10 (95% CI: 1.00 to 1.20) in women versus HR of 1.32 (95% CI: 1.24 to 1.41) in men; and NT-proBNP HR of 1.54 (95% CI: 1.37 to 1.74) in women versus HR of 1.89 (95% CI: 1.75 to 2.05) in men. Population-attributable risk of all risk factors combined was 59.0% in women and 62.9% in men. Conclusions: Women had a lower risk for HF than men. Sex differences were seen for systolic blood pressure, heart rate, CRP, and NT-proBNP, with a lower HF risk in women. |
format |
Article in Journal/Newspaper |
author |
Magnussen, C. Niiranen, T.J. Ojeda, F.M. Gianfagna, F. Blankenberg, S. Vartiainen, E. Sans, S. Pasterkamp, G. Hughes, M. Costanzo, S. Donati, M.B. Jousilahti, P. Linneberg, A. Palosaari, T. de Gaetano, G. Bobak, M. den Ruijter, H.M. Jørgensen, T. Söderberg, S. Kuulasmaa, K. Zeller, T. Iacoviello, L. Salomaa, V. Schnabel, R.B. |
author_facet |
Magnussen, C. Niiranen, T.J. Ojeda, F.M. Gianfagna, F. Blankenberg, S. Vartiainen, E. Sans, S. Pasterkamp, G. Hughes, M. Costanzo, S. Donati, M.B. Jousilahti, P. Linneberg, A. Palosaari, T. de Gaetano, G. Bobak, M. den Ruijter, H.M. Jørgensen, T. Söderberg, S. Kuulasmaa, K. Zeller, T. Iacoviello, L. Salomaa, V. Schnabel, R.B. |
author_sort |
Magnussen, C. |
title |
Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe:Results From the BiomarCaRE Consortium |
title_short |
Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe:Results From the BiomarCaRE Consortium |
title_full |
Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe:Results From the BiomarCaRE Consortium |
title_fullStr |
Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe:Results From the BiomarCaRE Consortium |
title_full_unstemmed |
Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe:Results From the BiomarCaRE Consortium |
title_sort |
sex-specific epidemiology of heart failure risk and mortality in europe:results from the biomarcare consortium |
publishDate |
2019 |
url |
https://vbn.aau.dk/da/publications/63638538-310a-4bca-9b42-917b0bbac43a https://doi.org/10.1016/j.jchf.2018.08.008 http://www.scopus.com/inward/record.url?scp=85061563131&partnerID=8YFLogxK https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061563131&doi=10.1016%2fj.jchf.2018.08.008&partnerID=40&md5=a4e7b725649906bd82cfefe9b718e808 |
long_lat |
ENVELOPE(19.182,19.182,69.227,69.227) |
geographic |
Moli |
geographic_facet |
Moli |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Magnussen , C , Niiranen , T J , Ojeda , F M , Gianfagna , F , Blankenberg , S , Vartiainen , E , Sans , S , Pasterkamp , G , Hughes , M , Costanzo , S , Donati , M B , Jousilahti , P , Linneberg , A , Palosaari , T , de Gaetano , G , Bobak , M , den Ruijter , H M , Jørgensen , T , Söderberg , S , Kuulasmaa , K , Zeller , T , Iacoviello , L , Salomaa , V , Schnabel , R B & BiomarCaRE Consortium 2019 , ' Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe : Results From the BiomarCaRE Consortium ' , J A C C: Heart Failure , vol. 7 , no. 3 , pp. 204-213 . https://doi.org/10.1016/j.jchf.2018.08.008 |
op_relation |
https://vbn.aau.dk/da/publications/63638538-310a-4bca-9b42-917b0bbac43a |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/j.jchf.2018.08.008 |
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JACC: Heart Failure |
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