Liver biochemistry and associations with alcohol intake, hepatitis B virus infection and Inuit ethnicity:a population-based comparative epidemiological survey in Greenland and Denmark
BACKGROUND: Hepatitis B virus (HBV) infection is common in Arctic populations and high alcohol intake has been associated with an increased risk of a number of diseases. Yet, a description of the influence of alcohol intake in persons with HBV infection on liver biochemistry is lacking. OBJECTIVE: W...
Published in: | International Journal of Circumpolar Health |
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2016
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Online Access: | https://vbn.aau.dk/da/publications/56379732-4678-4402-8601-08129314c66d https://doi.org/10.3402/ijch.v75.29528 https://www.scopus.com/record/display.uri?eid=2-s2.0-85013041487&origin=inward&txGid=03EB75B4FE440F5A345F107F454ED6B1.wsnAw8kcdt7IPYLO0V48gA%3a336 |
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ftalborgunivpubl:oai:pure.atira.dk:publications/56379732-4678-4402-8601-08129314c66d 2024-09-15T17:54:25+00:00 Liver biochemistry and associations with alcohol intake, hepatitis B virus infection and Inuit ethnicity:a population-based comparative epidemiological survey in Greenland and Denmark Rex, Karsten Fleischer Krarup, Henrik Bygum Laurberg, Peter Andersen, Stig 2016 https://vbn.aau.dk/da/publications/56379732-4678-4402-8601-08129314c66d https://doi.org/10.3402/ijch.v75.29528 https://www.scopus.com/record/display.uri?eid=2-s2.0-85013041487&origin=inward&txGid=03EB75B4FE440F5A345F107F454ED6B1.wsnAw8kcdt7IPYLO0V48gA%3a336 eng eng https://vbn.aau.dk/da/publications/56379732-4678-4402-8601-08129314c66d info:eu-repo/semantics/openAccess Rex , K F , Krarup , H B , Laurberg , P & Andersen , S 2016 , ' Liver biochemistry and associations with alcohol intake, hepatitis B virus infection and Inuit ethnicity : a population-based comparative epidemiological survey in Greenland and Denmark ' , International Journal of Circumpolar Health , vol. 75 , 29528 . https://doi.org/10.3402/ijch.v75.29528 article 2016 ftalborgunivpubl https://doi.org/10.3402/ijch.v75.29528 2024-07-10T12:49:20Z BACKGROUND: Hepatitis B virus (HBV) infection is common in Arctic populations and high alcohol intake has been associated with an increased risk of a number of diseases. Yet, a description of the influence of alcohol intake in persons with HBV infection on liver biochemistry is lacking. OBJECTIVE: We aimed to describe the association between reported alcohol intake and liver biochemistry taking into account also HBV infection, ethnicity, Inuit diet, body mass index (BMI), gender and age in an Arctic population. DESIGN AND METHODS: Population-based investigation of Inuit (n=441) and non-Inuit (94) in Greenland and Inuit living in Denmark (n=136). Participants filled in a questionnaire on alcohol intake and other life style factors. Blood samples were tested for aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), bilirubin, albumin, hepatitis B surface antigen, hepatitis B surface antibody and hepatitis B core antibody. We also performed physical examinations. RESULTS: Participation rate was 95% in Greenland and 52% in Denmark. An alcohol intake above the recommended level was reported by 12.9% of non-Inuit in Greenland, 9.1% of Inuit in East Greenland, 6.1% of Inuit migrants and 3.4% of Inuit in the capital of Greenland (p=0.035). Alcohol intake was associated with AST (p<0.001) and GGT (p=0.001), and HBV infection was associated with ALP (p=0.001) but not with AST, GGT, bilirubin or albumin in the adjusted analysis. Inuit had higher AST (p<0.001), GGT (p<0.001) and ALP (p=0.001) values than non-Inuit after adjustment for alcohol, diet, BMI and HBV exposure. Ethnic origin modified the association between alcohol and AST, while HBV infection did not modify the associations between alcohol and liver biochemistry. CONCLUSIONS: Non-Inuit in Greenland reported a higher alcohol intake than Inuit. Ethnic origin was more markedly associated with liver biochemistry than was alcohol intake, and Greenlandic ethnicity modified the effect of alcohol intake on AST. HBV ... Article in Journal/Newspaper Arctic Population Circumpolar Health East Greenland Greenland greenlandic International Journal of Circumpolar Health inuit Aalborg University's Research Portal International Journal of Circumpolar Health 75 1 29528 |
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Aalborg University's Research Portal |
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ftalborgunivpubl |
language |
English |
description |
BACKGROUND: Hepatitis B virus (HBV) infection is common in Arctic populations and high alcohol intake has been associated with an increased risk of a number of diseases. Yet, a description of the influence of alcohol intake in persons with HBV infection on liver biochemistry is lacking. OBJECTIVE: We aimed to describe the association between reported alcohol intake and liver biochemistry taking into account also HBV infection, ethnicity, Inuit diet, body mass index (BMI), gender and age in an Arctic population. DESIGN AND METHODS: Population-based investigation of Inuit (n=441) and non-Inuit (94) in Greenland and Inuit living in Denmark (n=136). Participants filled in a questionnaire on alcohol intake and other life style factors. Blood samples were tested for aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), bilirubin, albumin, hepatitis B surface antigen, hepatitis B surface antibody and hepatitis B core antibody. We also performed physical examinations. RESULTS: Participation rate was 95% in Greenland and 52% in Denmark. An alcohol intake above the recommended level was reported by 12.9% of non-Inuit in Greenland, 9.1% of Inuit in East Greenland, 6.1% of Inuit migrants and 3.4% of Inuit in the capital of Greenland (p=0.035). Alcohol intake was associated with AST (p<0.001) and GGT (p=0.001), and HBV infection was associated with ALP (p=0.001) but not with AST, GGT, bilirubin or albumin in the adjusted analysis. Inuit had higher AST (p<0.001), GGT (p<0.001) and ALP (p=0.001) values than non-Inuit after adjustment for alcohol, diet, BMI and HBV exposure. Ethnic origin modified the association between alcohol and AST, while HBV infection did not modify the associations between alcohol and liver biochemistry. CONCLUSIONS: Non-Inuit in Greenland reported a higher alcohol intake than Inuit. Ethnic origin was more markedly associated with liver biochemistry than was alcohol intake, and Greenlandic ethnicity modified the effect of alcohol intake on AST. HBV ... |
format |
Article in Journal/Newspaper |
author |
Rex, Karsten Fleischer Krarup, Henrik Bygum Laurberg, Peter Andersen, Stig |
spellingShingle |
Rex, Karsten Fleischer Krarup, Henrik Bygum Laurberg, Peter Andersen, Stig Liver biochemistry and associations with alcohol intake, hepatitis B virus infection and Inuit ethnicity:a population-based comparative epidemiological survey in Greenland and Denmark |
author_facet |
Rex, Karsten Fleischer Krarup, Henrik Bygum Laurberg, Peter Andersen, Stig |
author_sort |
Rex, Karsten Fleischer |
title |
Liver biochemistry and associations with alcohol intake, hepatitis B virus infection and Inuit ethnicity:a population-based comparative epidemiological survey in Greenland and Denmark |
title_short |
Liver biochemistry and associations with alcohol intake, hepatitis B virus infection and Inuit ethnicity:a population-based comparative epidemiological survey in Greenland and Denmark |
title_full |
Liver biochemistry and associations with alcohol intake, hepatitis B virus infection and Inuit ethnicity:a population-based comparative epidemiological survey in Greenland and Denmark |
title_fullStr |
Liver biochemistry and associations with alcohol intake, hepatitis B virus infection and Inuit ethnicity:a population-based comparative epidemiological survey in Greenland and Denmark |
title_full_unstemmed |
Liver biochemistry and associations with alcohol intake, hepatitis B virus infection and Inuit ethnicity:a population-based comparative epidemiological survey in Greenland and Denmark |
title_sort |
liver biochemistry and associations with alcohol intake, hepatitis b virus infection and inuit ethnicity:a population-based comparative epidemiological survey in greenland and denmark |
publishDate |
2016 |
url |
https://vbn.aau.dk/da/publications/56379732-4678-4402-8601-08129314c66d https://doi.org/10.3402/ijch.v75.29528 https://www.scopus.com/record/display.uri?eid=2-s2.0-85013041487&origin=inward&txGid=03EB75B4FE440F5A345F107F454ED6B1.wsnAw8kcdt7IPYLO0V48gA%3a336 |
genre |
Arctic Population Circumpolar Health East Greenland Greenland greenlandic International Journal of Circumpolar Health inuit |
genre_facet |
Arctic Population Circumpolar Health East Greenland Greenland greenlandic International Journal of Circumpolar Health inuit |
op_source |
Rex , K F , Krarup , H B , Laurberg , P & Andersen , S 2016 , ' Liver biochemistry and associations with alcohol intake, hepatitis B virus infection and Inuit ethnicity : a population-based comparative epidemiological survey in Greenland and Denmark ' , International Journal of Circumpolar Health , vol. 75 , 29528 . https://doi.org/10.3402/ijch.v75.29528 |
op_relation |
https://vbn.aau.dk/da/publications/56379732-4678-4402-8601-08129314c66d |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3402/ijch.v75.29528 |
container_title |
International Journal of Circumpolar Health |
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75 |
container_issue |
1 |
container_start_page |
29528 |
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1810430741921660928 |