Risk of hepatitis B when migrating from low to high endemic areas
Prevalence of hepatitis B virus (HBV) infections varies markedly with geography and is endemic in the Arctic. Travel and migration have increased markedly while the influence of migration to high endemic areas remains unknown. We surveyed subjects migrating from an area with a low prevalence of chro...
Published in: | International Journal of Circumpolar Health |
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Format: | Article in Journal/Newspaper |
Language: | English |
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2020
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Online Access: | https://vbn.aau.dk/da/publications/432d6ae1-33e3-4f46-bfd9-0db397276e79 https://doi.org/10.1080/22423982.2020.1817274 https://vbn.aau.dk/ws/files/360899042/Krarup_et_al_2020_Risk_of_hepatitis_B_when_migrating_from_low_to_high_endemic_areas.pdf http://www.scopus.com/inward/record.url?scp=85090203195&partnerID=8YFLogxK |
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ftalborgunivpubl:oai:pure.atira.dk:publications/432d6ae1-33e3-4f46-bfd9-0db397276e79 2024-10-06T13:46:25+00:00 Risk of hepatitis B when migrating from low to high endemic areas Krarup, Henrik Bygum Rex, Karsten Fleischer Andersen, Stig 2020-01-01 application/pdf https://vbn.aau.dk/da/publications/432d6ae1-33e3-4f46-bfd9-0db397276e79 https://doi.org/10.1080/22423982.2020.1817274 https://vbn.aau.dk/ws/files/360899042/Krarup_et_al_2020_Risk_of_hepatitis_B_when_migrating_from_low_to_high_endemic_areas.pdf http://www.scopus.com/inward/record.url?scp=85090203195&partnerID=8YFLogxK eng eng https://vbn.aau.dk/da/publications/432d6ae1-33e3-4f46-bfd9-0db397276e79 info:eu-repo/semantics/openAccess Krarup , H B , Rex , K F & Andersen , S 2020 , ' Risk of hepatitis B when migrating from low to high endemic areas ' , International Journal of Circumpolar Health , vol. 79 , no. 1 , 1817274 . https://doi.org/10.1080/22423982.2020.1817274 arctic Hepatitis B high endemic low endemic migration vaccination article 2020 ftalborgunivpubl https://doi.org/10.1080/22423982.2020.1817274 2024-09-12T00:34:02Z Prevalence of hepatitis B virus (HBV) infections varies markedly with geography and is endemic in the Arctic. Travel and migration have increased markedly while the influence of migration to high endemic areas remains unknown. We surveyed subjects migrating from an area with a low prevalence of chronic HBV infection (Denmark, 0.01%) to an endemic HBV area (West- and East Greenland, 3% and 29%) in order to describe the prevalence of HBV exposure among migrants. We included 198 Caucasian Danes that had migrated to Greenland and repeated the cross-sectional investigation after 10 years. We performed thorough serological testing for HBV. None had ongoing HBV infection. Migrants to East Greenland were more frequently exposed to HBV than those in West Greenland (34.3% vs 10.3%; p < 0.01). This difference was reduced at 10-year follow-up (8.1% vs 5.7%; ns) and the overall number of participants with past HBV infection decreased over the 10-year period from 19.4% to 6.9% (p = 0.02). In conclusion, migration from very low prevalence to endemic HBV areas associated with a markedly increased risk of exposure to HBV. Lack of vaccination among migrants from Denmark to Greenland was frequent and it poses a continuing risk. All who migrate from low to high endemic HBV areas should be vaccinated. Abbreviations: HBV: Hepatitis B virus; HBV-DNA: Hepatitis B virus deoxyribonucleic acid; HBsAg: Hepatitis B surface antigen; Anti-HBs: Antibodies against hepatitis B surface antigen; Anti-HBc: Antibodies against hepatitis B core antigen; BMI: Body mass index. Article in Journal/Newspaper Arctic Circumpolar Health East Greenland Greenland International Journal of Circumpolar Health Aalborg University's Research Portal Arctic Greenland International Journal of Circumpolar Health 79 1 1817274 |
institution |
Open Polar |
collection |
Aalborg University's Research Portal |
op_collection_id |
ftalborgunivpubl |
language |
English |
topic |
arctic Hepatitis B high endemic low endemic migration vaccination |
spellingShingle |
arctic Hepatitis B high endemic low endemic migration vaccination Krarup, Henrik Bygum Rex, Karsten Fleischer Andersen, Stig Risk of hepatitis B when migrating from low to high endemic areas |
topic_facet |
arctic Hepatitis B high endemic low endemic migration vaccination |
description |
Prevalence of hepatitis B virus (HBV) infections varies markedly with geography and is endemic in the Arctic. Travel and migration have increased markedly while the influence of migration to high endemic areas remains unknown. We surveyed subjects migrating from an area with a low prevalence of chronic HBV infection (Denmark, 0.01%) to an endemic HBV area (West- and East Greenland, 3% and 29%) in order to describe the prevalence of HBV exposure among migrants. We included 198 Caucasian Danes that had migrated to Greenland and repeated the cross-sectional investigation after 10 years. We performed thorough serological testing for HBV. None had ongoing HBV infection. Migrants to East Greenland were more frequently exposed to HBV than those in West Greenland (34.3% vs 10.3%; p < 0.01). This difference was reduced at 10-year follow-up (8.1% vs 5.7%; ns) and the overall number of participants with past HBV infection decreased over the 10-year period from 19.4% to 6.9% (p = 0.02). In conclusion, migration from very low prevalence to endemic HBV areas associated with a markedly increased risk of exposure to HBV. Lack of vaccination among migrants from Denmark to Greenland was frequent and it poses a continuing risk. All who migrate from low to high endemic HBV areas should be vaccinated. Abbreviations: HBV: Hepatitis B virus; HBV-DNA: Hepatitis B virus deoxyribonucleic acid; HBsAg: Hepatitis B surface antigen; Anti-HBs: Antibodies against hepatitis B surface antigen; Anti-HBc: Antibodies against hepatitis B core antigen; BMI: Body mass index. |
format |
Article in Journal/Newspaper |
author |
Krarup, Henrik Bygum Rex, Karsten Fleischer Andersen, Stig |
author_facet |
Krarup, Henrik Bygum Rex, Karsten Fleischer Andersen, Stig |
author_sort |
Krarup, Henrik Bygum |
title |
Risk of hepatitis B when migrating from low to high endemic areas |
title_short |
Risk of hepatitis B when migrating from low to high endemic areas |
title_full |
Risk of hepatitis B when migrating from low to high endemic areas |
title_fullStr |
Risk of hepatitis B when migrating from low to high endemic areas |
title_full_unstemmed |
Risk of hepatitis B when migrating from low to high endemic areas |
title_sort |
risk of hepatitis b when migrating from low to high endemic areas |
publishDate |
2020 |
url |
https://vbn.aau.dk/da/publications/432d6ae1-33e3-4f46-bfd9-0db397276e79 https://doi.org/10.1080/22423982.2020.1817274 https://vbn.aau.dk/ws/files/360899042/Krarup_et_al_2020_Risk_of_hepatitis_B_when_migrating_from_low_to_high_endemic_areas.pdf http://www.scopus.com/inward/record.url?scp=85090203195&partnerID=8YFLogxK |
geographic |
Arctic Greenland |
geographic_facet |
Arctic Greenland |
genre |
Arctic Circumpolar Health East Greenland Greenland International Journal of Circumpolar Health |
genre_facet |
Arctic Circumpolar Health East Greenland Greenland International Journal of Circumpolar Health |
op_source |
Krarup , H B , Rex , K F & Andersen , S 2020 , ' Risk of hepatitis B when migrating from low to high endemic areas ' , International Journal of Circumpolar Health , vol. 79 , no. 1 , 1817274 . https://doi.org/10.1080/22423982.2020.1817274 |
op_relation |
https://vbn.aau.dk/da/publications/432d6ae1-33e3-4f46-bfd9-0db397276e79 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1080/22423982.2020.1817274 |
container_title |
International Journal of Circumpolar Health |
container_volume |
79 |
container_issue |
1 |
container_start_page |
1817274 |
_version_ |
1812174745592922112 |