Climate-associated drivers of plasma cytokines and contaminant concentrations in Beaufort Sea polar bears (Ursus maritimus)
Assessing polar bear (Ursus maritimus) immune function in relation to environmental stressors, including habitat change, nutritional stress, pathogen prevalence, and pollution, has been identified as critical for improved understanding of the species' health. The objectives of this study were t...
Published in: | Science of The Total Environment |
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2020
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Online Access: | https://vbn.aau.dk/da/publications/35482467-bb58-4b96-b0ed-d11d1e3e3099 https://doi.org/10.1016/j.scitotenv.2020.140978 http://www.scopus.com/inward/record.url?scp=85088659673&partnerID=8YFLogxK |
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ftalborgunivpubl:oai:pure.atira.dk:publications/35482467-bb58-4b96-b0ed-d11d1e3e3099 2024-05-19T07:36:50+00:00 Climate-associated drivers of plasma cytokines and contaminant concentrations in Beaufort Sea polar bears (Ursus maritimus) Bourque, Jennifer Desforges, Jean Pierre Levin, Milton Atwood, Todd C. Sonne, Christian Dietz, Rune Jensen, Trine H. Curry, Erin McKinney, Melissa A. 2020-11-25 https://vbn.aau.dk/da/publications/35482467-bb58-4b96-b0ed-d11d1e3e3099 https://doi.org/10.1016/j.scitotenv.2020.140978 http://www.scopus.com/inward/record.url?scp=85088659673&partnerID=8YFLogxK eng eng https://vbn.aau.dk/da/publications/35482467-bb58-4b96-b0ed-d11d1e3e3099 info:eu-repo/semantics/closedAccess Bourque , J , Desforges , J P , Levin , M , Atwood , T C , Sonne , C , Dietz , R , Jensen , T H , Curry , E & McKinney , M A 2020 , ' Climate-associated drivers of plasma cytokines and contaminant concentrations in Beaufort Sea polar bears (Ursus maritimus) ' , Science of the Total Environment , vol. 745 , 140978 . https://doi.org/10.1016/j.scitotenv.2020.140978 Arctic Contaminants Cytokines Immune response Sea ice loss Ursus maritimus article 2020 ftalborgunivpubl https://doi.org/10.1016/j.scitotenv.2020.140978 2024-04-29T00:47:44Z Assessing polar bear (Ursus maritimus) immune function in relation to environmental stressors, including habitat change, nutritional stress, pathogen prevalence, and pollution, has been identified as critical for improved understanding of the species' health. The objectives of this study were two-fold: 1) to assess the role of climate-associated factors (habitat use, body condition) in explaining the plasma concentrations of contaminants in southern Beaufort Sea (SB) polar bears, and 2) to investigate how climate-associated factors, contaminant concentrations, and pathogen sero-prevalence influence the plasma concentrations of immune-signaling proteins called cytokines. A commercially available multiplex canine cytokine panel was validated for the quantification of five pro- and anti-inflammatory cytokines in polar bear plasma: tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), IL-8, IL-10, and interferon gamma-induced protein 10 (IP-10). This panel was then used to measure cytokine concentrations in 49 SB polar bears sampled in the springs of 2013 and 2014. Mean ∑PCBs (plasma), ∑OCs (plasma), and THg (hair) were 13.01 ± 1.52 ng g −1 w.w. (range: 0.17–52.63), 19.46 ± 1.17 ng g −1 w.w. (range: 6.63–45.82), and 0.49 μg g −1 d.w. (range: 0.99–15.18), respectively. Top models explaining variation in concentrations of plasma PCBs, plasma OC pesticides, and hair THg in SB polar bears included body mass index and/or habitat use (onshore versus offshore), with higher contaminant concentrations in leaner and/or offshore bears. Plasma cytokine concentrations were influenced most strongly by plasma PCBs and age, with little to no influence found for plasma OCs or hair THg concentrations, habitat use, or pathogen sero-prevalence. The lack of association between cytokines and these latter variables is likely due to a temporal disconnect between measured endpoints. The change of polar bear habitat use, feeding ecology, and body condition with ongoing climate warming is affecting exposure to contaminants and pathogens, ... Article in Journal/Newspaper Arctic Beaufort Sea Sea ice Ursus maritimus Aalborg University's Research Portal Science of The Total Environment 745 140978 |
institution |
Open Polar |
collection |
Aalborg University's Research Portal |
op_collection_id |
ftalborgunivpubl |
language |
English |
topic |
Arctic Contaminants Cytokines Immune response Sea ice loss Ursus maritimus |
spellingShingle |
Arctic Contaminants Cytokines Immune response Sea ice loss Ursus maritimus Bourque, Jennifer Desforges, Jean Pierre Levin, Milton Atwood, Todd C. Sonne, Christian Dietz, Rune Jensen, Trine H. Curry, Erin McKinney, Melissa A. Climate-associated drivers of plasma cytokines and contaminant concentrations in Beaufort Sea polar bears (Ursus maritimus) |
topic_facet |
Arctic Contaminants Cytokines Immune response Sea ice loss Ursus maritimus |
description |
Assessing polar bear (Ursus maritimus) immune function in relation to environmental stressors, including habitat change, nutritional stress, pathogen prevalence, and pollution, has been identified as critical for improved understanding of the species' health. The objectives of this study were two-fold: 1) to assess the role of climate-associated factors (habitat use, body condition) in explaining the plasma concentrations of contaminants in southern Beaufort Sea (SB) polar bears, and 2) to investigate how climate-associated factors, contaminant concentrations, and pathogen sero-prevalence influence the plasma concentrations of immune-signaling proteins called cytokines. A commercially available multiplex canine cytokine panel was validated for the quantification of five pro- and anti-inflammatory cytokines in polar bear plasma: tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), IL-8, IL-10, and interferon gamma-induced protein 10 (IP-10). This panel was then used to measure cytokine concentrations in 49 SB polar bears sampled in the springs of 2013 and 2014. Mean ∑PCBs (plasma), ∑OCs (plasma), and THg (hair) were 13.01 ± 1.52 ng g −1 w.w. (range: 0.17–52.63), 19.46 ± 1.17 ng g −1 w.w. (range: 6.63–45.82), and 0.49 μg g −1 d.w. (range: 0.99–15.18), respectively. Top models explaining variation in concentrations of plasma PCBs, plasma OC pesticides, and hair THg in SB polar bears included body mass index and/or habitat use (onshore versus offshore), with higher contaminant concentrations in leaner and/or offshore bears. Plasma cytokine concentrations were influenced most strongly by plasma PCBs and age, with little to no influence found for plasma OCs or hair THg concentrations, habitat use, or pathogen sero-prevalence. The lack of association between cytokines and these latter variables is likely due to a temporal disconnect between measured endpoints. The change of polar bear habitat use, feeding ecology, and body condition with ongoing climate warming is affecting exposure to contaminants and pathogens, ... |
format |
Article in Journal/Newspaper |
author |
Bourque, Jennifer Desforges, Jean Pierre Levin, Milton Atwood, Todd C. Sonne, Christian Dietz, Rune Jensen, Trine H. Curry, Erin McKinney, Melissa A. |
author_facet |
Bourque, Jennifer Desforges, Jean Pierre Levin, Milton Atwood, Todd C. Sonne, Christian Dietz, Rune Jensen, Trine H. Curry, Erin McKinney, Melissa A. |
author_sort |
Bourque, Jennifer |
title |
Climate-associated drivers of plasma cytokines and contaminant concentrations in Beaufort Sea polar bears (Ursus maritimus) |
title_short |
Climate-associated drivers of plasma cytokines and contaminant concentrations in Beaufort Sea polar bears (Ursus maritimus) |
title_full |
Climate-associated drivers of plasma cytokines and contaminant concentrations in Beaufort Sea polar bears (Ursus maritimus) |
title_fullStr |
Climate-associated drivers of plasma cytokines and contaminant concentrations in Beaufort Sea polar bears (Ursus maritimus) |
title_full_unstemmed |
Climate-associated drivers of plasma cytokines and contaminant concentrations in Beaufort Sea polar bears (Ursus maritimus) |
title_sort |
climate-associated drivers of plasma cytokines and contaminant concentrations in beaufort sea polar bears (ursus maritimus) |
publishDate |
2020 |
url |
https://vbn.aau.dk/da/publications/35482467-bb58-4b96-b0ed-d11d1e3e3099 https://doi.org/10.1016/j.scitotenv.2020.140978 http://www.scopus.com/inward/record.url?scp=85088659673&partnerID=8YFLogxK |
genre |
Arctic Beaufort Sea Sea ice Ursus maritimus |
genre_facet |
Arctic Beaufort Sea Sea ice Ursus maritimus |
op_source |
Bourque , J , Desforges , J P , Levin , M , Atwood , T C , Sonne , C , Dietz , R , Jensen , T H , Curry , E & McKinney , M A 2020 , ' Climate-associated drivers of plasma cytokines and contaminant concentrations in Beaufort Sea polar bears (Ursus maritimus) ' , Science of the Total Environment , vol. 745 , 140978 . https://doi.org/10.1016/j.scitotenv.2020.140978 |
op_relation |
https://vbn.aau.dk/da/publications/35482467-bb58-4b96-b0ed-d11d1e3e3099 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/j.scitotenv.2020.140978 |
container_title |
Science of The Total Environment |
container_volume |
745 |
container_start_page |
140978 |
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1799475987337969664 |