Biochemical and molecular characterization of an original master sex determining gene in salmonids
Sexual development is a fundamental and versatile process that shapes animal morphology, physiology and behavior. The underlying developmental process is composed of the sex determination and the sex differentiation. The initial triggers are often genetics called sex determining genes. To date, amon...
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ftagrocampouest:oai:HAL:tel-01686524v1 2024-09-15T17:56:35+00:00 Biochemical and molecular characterization of an original master sex determining gene in salmonids Caractérisation biochimique et moléculaire du déterminant du sexe chez les salmonidés Bertho, Sylvain Laboratoire de Physiologie et Génomique des Poissons (LPGP) Institut National de la Recherche Agronomique (INRA)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) Agrocampus Ouest Universitätsbibliothek (Wurtzbourg, Allemagne) Manfred Schartl Yann Guiguen 2016-06-23 https://theses.hal.science/tel-01686524 https://theses.hal.science/tel-01686524/document https://theses.hal.science/tel-01686524/file/pdf2star-1516179696-pdfa_G7UO3xZaBertho.pdf en eng HAL CCSD NNT: 2016NSARB279 tel-01686524 https://theses.hal.science/tel-01686524 https://theses.hal.science/tel-01686524/document https://theses.hal.science/tel-01686524/file/pdf2star-1516179696-pdfa_G7UO3xZaBertho.pdf info:eu-repo/semantics/OpenAccess https://theses.hal.science/tel-01686524 Animal biology. Agrocampus Ouest; Universitätsbibliothek (Wurtzbourg, Allemagne), 2016. English. ⟨NNT : 2016NSARB279⟩ Sex development Sex determination pathways SdY Foxl2 Salmonids Développement du sexe Voies de détermination du sexe Salmonidés [SDV.BA]Life Sciences [q-bio]/Animal biology info:eu-repo/semantics/doctoralThesis Theses 2016 ftagrocampouest 2024-07-15T23:40:27Z Sexual development is a fundamental and versatile process that shapes animal morphology, physiology and behavior. The underlying developmental process is composed of the sex determination and the sex differentiation. The initial triggers are often genetics called sex determining genes. To date, among the known sex determining genes, three gene families namely sox, dmrt and TGF-ß factors govern this developmental program. As exception to this rule, sdY “sexually dimorphic on the Y” does not belong to one of these families as it comes from the duplication / evolution of an ancestor gene related to immunity, i.e., the interferon related factor 9, irf9.sdY is the master sex determining gene in salmonids, a group of fishes that include species such as rainbow trout and Atlantic salmon. The present study was aimed to firstly characterize the features of SdY protein. Results indicate that SdY is predominantly localized in the cytoplasm, composed of a ß-sandwich core surrounded by three a-helices as well specific characteristics conferring a putative protein-protein interaction site. Secondly, the study was aimed to understand how SdY could trigger testicular differentiation. Altogether results propose that SdY would trigger testicular differentiation in salmonids by interacting with a prominent female factor. Le développement du sexe est un processus fondamental et versatile qui forme la morphologie, la physiologie et le comportement des animaux. Le processus de développement sous-jacent est composé de la détermination et de la différentiation du sexe. Les mécanismes de détermination du sexe sont souvent génétiques et nommés gènes de détermination du sexe. A l’heure actuelle, parmi les gènes de détermination connus, trois familles de gènes nommément sox, dmrt and les facteurs TGF-ß gouvernent ce processus de développement.Comme exception à cette règle, sdY « sexually dimorphic on the Y » n’appartient à aucune de ces familles puisqu’il provient d’une duplication/évolution d’un gène ancestral de l’immunité, ... Doctoral or Postdoctoral Thesis Atlantic salmon Agrocampus Ouest: HAL |
institution |
Open Polar |
collection |
Agrocampus Ouest: HAL |
op_collection_id |
ftagrocampouest |
language |
English |
topic |
Sex development Sex determination pathways SdY Foxl2 Salmonids Développement du sexe Voies de détermination du sexe Salmonidés [SDV.BA]Life Sciences [q-bio]/Animal biology |
spellingShingle |
Sex development Sex determination pathways SdY Foxl2 Salmonids Développement du sexe Voies de détermination du sexe Salmonidés [SDV.BA]Life Sciences [q-bio]/Animal biology Bertho, Sylvain Biochemical and molecular characterization of an original master sex determining gene in salmonids |
topic_facet |
Sex development Sex determination pathways SdY Foxl2 Salmonids Développement du sexe Voies de détermination du sexe Salmonidés [SDV.BA]Life Sciences [q-bio]/Animal biology |
description |
Sexual development is a fundamental and versatile process that shapes animal morphology, physiology and behavior. The underlying developmental process is composed of the sex determination and the sex differentiation. The initial triggers are often genetics called sex determining genes. To date, among the known sex determining genes, three gene families namely sox, dmrt and TGF-ß factors govern this developmental program. As exception to this rule, sdY “sexually dimorphic on the Y” does not belong to one of these families as it comes from the duplication / evolution of an ancestor gene related to immunity, i.e., the interferon related factor 9, irf9.sdY is the master sex determining gene in salmonids, a group of fishes that include species such as rainbow trout and Atlantic salmon. The present study was aimed to firstly characterize the features of SdY protein. Results indicate that SdY is predominantly localized in the cytoplasm, composed of a ß-sandwich core surrounded by three a-helices as well specific characteristics conferring a putative protein-protein interaction site. Secondly, the study was aimed to understand how SdY could trigger testicular differentiation. Altogether results propose that SdY would trigger testicular differentiation in salmonids by interacting with a prominent female factor. Le développement du sexe est un processus fondamental et versatile qui forme la morphologie, la physiologie et le comportement des animaux. Le processus de développement sous-jacent est composé de la détermination et de la différentiation du sexe. Les mécanismes de détermination du sexe sont souvent génétiques et nommés gènes de détermination du sexe. A l’heure actuelle, parmi les gènes de détermination connus, trois familles de gènes nommément sox, dmrt and les facteurs TGF-ß gouvernent ce processus de développement.Comme exception à cette règle, sdY « sexually dimorphic on the Y » n’appartient à aucune de ces familles puisqu’il provient d’une duplication/évolution d’un gène ancestral de l’immunité, ... |
author2 |
Laboratoire de Physiologie et Génomique des Poissons (LPGP) Institut National de la Recherche Agronomique (INRA)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) Agrocampus Ouest Universitätsbibliothek (Wurtzbourg, Allemagne) Manfred Schartl Yann Guiguen |
format |
Doctoral or Postdoctoral Thesis |
author |
Bertho, Sylvain |
author_facet |
Bertho, Sylvain |
author_sort |
Bertho, Sylvain |
title |
Biochemical and molecular characterization of an original master sex determining gene in salmonids |
title_short |
Biochemical and molecular characterization of an original master sex determining gene in salmonids |
title_full |
Biochemical and molecular characterization of an original master sex determining gene in salmonids |
title_fullStr |
Biochemical and molecular characterization of an original master sex determining gene in salmonids |
title_full_unstemmed |
Biochemical and molecular characterization of an original master sex determining gene in salmonids |
title_sort |
biochemical and molecular characterization of an original master sex determining gene in salmonids |
publisher |
HAL CCSD |
publishDate |
2016 |
url |
https://theses.hal.science/tel-01686524 https://theses.hal.science/tel-01686524/document https://theses.hal.science/tel-01686524/file/pdf2star-1516179696-pdfa_G7UO3xZaBertho.pdf |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
https://theses.hal.science/tel-01686524 Animal biology. Agrocampus Ouest; Universitätsbibliothek (Wurtzbourg, Allemagne), 2016. English. ⟨NNT : 2016NSARB279⟩ |
op_relation |
NNT: 2016NSARB279 tel-01686524 https://theses.hal.science/tel-01686524 https://theses.hal.science/tel-01686524/document https://theses.hal.science/tel-01686524/file/pdf2star-1516179696-pdfa_G7UO3xZaBertho.pdf |
op_rights |
info:eu-repo/semantics/OpenAccess |
_version_ |
1810432773337382912 |