The genetic structure of Norway
The aim of the present study was to describe the genetic structure of the Norwegian population using genotypes from 6369 unrelated individuals with detailed information about places of residence. Using standard single marker- and haplotypebased approaches, we report evidence of two regions with dist...
Published in: | European Journal of Human Genetics |
---|---|
Main Authors: | , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Nature Publishing Group
2021
|
Subjects: | |
Online Access: | https://hdl.handle.net/11250/2988807 https://doi.org/10.1038/s41431-021-00899-6 |
id |
ftagderuniv:oai:uia.brage.unit.no:11250/2988807 |
---|---|
record_format |
openpolar |
spelling |
ftagderuniv:oai:uia.brage.unit.no:11250/2988807 2023-05-15T18:12:12+02:00 The genetic structure of Norway Mattingsdal, Morten Ebenesersdóttir, Sigríður Sunna Moore, Kristjan H. S. Andreassen, Ole Andreas Hansen, Thomas F. Werge, Thomas Kockum, Ingrid Olsson, Tomas Alfredsson, Lars Helgason, Agnar Stefánsson, Kári Hovig, Johannes Eivind 2021 application/pdf https://hdl.handle.net/11250/2988807 https://doi.org/10.1038/s41431-021-00899-6 eng eng Nature Publishing Group Mattingsdal, M., Ebenesersdóttir, S. S., Moore, K. H. S., Andreassen, O. A., Hansen, T. F., Werge, T., Kockum, I., Olsson, T., Alfredsson, L., Helgason, A., Stefánsson, K. & Hovig, J. E. (2021). The genetic structure of Norway. European Journal of Human Genetics, 29, 1710-1718. urn:issn:1476-5438 https://hdl.handle.net/11250/2988807 https://doi.org/10.1038/s41431-021-00899-6 cristin:1925327 Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no © The Author(s) CC-BY 1710-1718 29 European Journal of Human Genetics VDP::Samfunnsvitenskap: 200 Peer reviewed Journal article 2021 ftagderuniv https://doi.org/10.1038/s41431-021-00899-6 2022-12-11T06:50:55Z The aim of the present study was to describe the genetic structure of the Norwegian population using genotypes from 6369 unrelated individuals with detailed information about places of residence. Using standard single marker- and haplotypebased approaches, we report evidence of two regions with distinctive patterns of genetic variation, one in the far northeast, and another in the south of Norway, as indicated by fixation indices, haplotype sharing, homozygosity, and effective population size. We detect and quantify a component of Uralic Sami ancestry that is enriched in the North. On a finer scale, we find that rates of migration have been affected by topography like mountain ridges. In the broader Scandinavian context, we detect elevated relatedness between the mid- and northern border areas towards Sweden. The main finding of this study is that despite Norway’s long maritime history and as a former Danish territory, the region closest to mainland Europe in the south appears to have been an isolated region in Norway, highlighting the open sea as a barrier to gene flow into Norway. publishedVersion Article in Journal/Newspaper sami Unvieristy of Agder: AURA (Brage) Norway European Journal of Human Genetics 29 11 1710 1718 |
institution |
Open Polar |
collection |
Unvieristy of Agder: AURA (Brage) |
op_collection_id |
ftagderuniv |
language |
English |
topic |
VDP::Samfunnsvitenskap: 200 |
spellingShingle |
VDP::Samfunnsvitenskap: 200 Mattingsdal, Morten Ebenesersdóttir, Sigríður Sunna Moore, Kristjan H. S. Andreassen, Ole Andreas Hansen, Thomas F. Werge, Thomas Kockum, Ingrid Olsson, Tomas Alfredsson, Lars Helgason, Agnar Stefánsson, Kári Hovig, Johannes Eivind The genetic structure of Norway |
topic_facet |
VDP::Samfunnsvitenskap: 200 |
description |
The aim of the present study was to describe the genetic structure of the Norwegian population using genotypes from 6369 unrelated individuals with detailed information about places of residence. Using standard single marker- and haplotypebased approaches, we report evidence of two regions with distinctive patterns of genetic variation, one in the far northeast, and another in the south of Norway, as indicated by fixation indices, haplotype sharing, homozygosity, and effective population size. We detect and quantify a component of Uralic Sami ancestry that is enriched in the North. On a finer scale, we find that rates of migration have been affected by topography like mountain ridges. In the broader Scandinavian context, we detect elevated relatedness between the mid- and northern border areas towards Sweden. The main finding of this study is that despite Norway’s long maritime history and as a former Danish territory, the region closest to mainland Europe in the south appears to have been an isolated region in Norway, highlighting the open sea as a barrier to gene flow into Norway. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Mattingsdal, Morten Ebenesersdóttir, Sigríður Sunna Moore, Kristjan H. S. Andreassen, Ole Andreas Hansen, Thomas F. Werge, Thomas Kockum, Ingrid Olsson, Tomas Alfredsson, Lars Helgason, Agnar Stefánsson, Kári Hovig, Johannes Eivind |
author_facet |
Mattingsdal, Morten Ebenesersdóttir, Sigríður Sunna Moore, Kristjan H. S. Andreassen, Ole Andreas Hansen, Thomas F. Werge, Thomas Kockum, Ingrid Olsson, Tomas Alfredsson, Lars Helgason, Agnar Stefánsson, Kári Hovig, Johannes Eivind |
author_sort |
Mattingsdal, Morten |
title |
The genetic structure of Norway |
title_short |
The genetic structure of Norway |
title_full |
The genetic structure of Norway |
title_fullStr |
The genetic structure of Norway |
title_full_unstemmed |
The genetic structure of Norway |
title_sort |
genetic structure of norway |
publisher |
Nature Publishing Group |
publishDate |
2021 |
url |
https://hdl.handle.net/11250/2988807 https://doi.org/10.1038/s41431-021-00899-6 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
sami |
genre_facet |
sami |
op_source |
1710-1718 29 European Journal of Human Genetics |
op_relation |
Mattingsdal, M., Ebenesersdóttir, S. S., Moore, K. H. S., Andreassen, O. A., Hansen, T. F., Werge, T., Kockum, I., Olsson, T., Alfredsson, L., Helgason, A., Stefánsson, K. & Hovig, J. E. (2021). The genetic structure of Norway. European Journal of Human Genetics, 29, 1710-1718. urn:issn:1476-5438 https://hdl.handle.net/11250/2988807 https://doi.org/10.1038/s41431-021-00899-6 cristin:1925327 |
op_rights |
Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no © The Author(s) |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/s41431-021-00899-6 |
container_title |
European Journal of Human Genetics |
container_volume |
29 |
container_issue |
11 |
container_start_page |
1710 |
op_container_end_page |
1718 |
_version_ |
1766184753485053952 |