Genomic characterization of the Atlantic cod sex-locus
A variety of sex determination mechanisms can be observed in evolutionary divergent teleosts. Sex determination is genetic in Atlantic cod (Gadus morhua), however the genomic location or size of its sex-locus is unknown. Here, we characterize the sex-locus of Atlantic cod using whole genome sequence...
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ftagderuniv:oai:uia.brage.unit.no:11250/2484959 2023-05-15T15:26:50+02:00 Genomic characterization of the Atlantic cod sex-locus Star, Bastiaan Tørresen, Ole Kristian Nederbragt, Alexander Johan Jakobsen, Kjetill Sigurd Pampoulie, Christophe Jentoft, Sissel 2016 application/pdf http://hdl.handle.net/11250/2484959 https://doi.org/10.1038/srep31235 eng eng Nature Publishing Norges forskningsråd: 179569 Norges forskningsråd: 221734 Norges forskningsråd: 203850 Notur/NorStore: nn9244k Scientific Reports. 2016, 6 1-9. urn:issn:2045-2322 http://hdl.handle.net/11250/2484959 https://doi.org/10.1038/srep31235 cristin:1375905 Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no CC-BY 1-9 6 Scientific Reports Journal article Peer reviewed 2016 ftagderuniv https://doi.org/10.1038/srep31235 2022-12-11T06:50:47Z A variety of sex determination mechanisms can be observed in evolutionary divergent teleosts. Sex determination is genetic in Atlantic cod (Gadus morhua), however the genomic location or size of its sex-locus is unknown. Here, we characterize the sex-locus of Atlantic cod using whole genome sequence (WGS) data of 227 wild-caught specimens. Analyzing more than 55 million polymorphic loci, we identify 166 loci that are associated with sex. These loci are located in six distinct regions on fve diferent linkage groups (LG) in the genome. The largest of these regions, an approximately 55Kb region on LG11, contains the majority of genotypes that segregate closely according to a XX-XY system. Genotypes in this region can be used genetically determine sex, whereas those in the other regions are inconsistently sex-linked. The identifed region on LG11 and its surrounding genes have no clear sequence homology with genes or regulatory elements associated with sex-determination or diferentiation in other species. The functionality of this sex-locus therefore remains unknown. The WGS strategy used here proved adequate for detecting the small regions associated with sex in this species. Our results highlight the evolutionary fexibility in genomic architecture underlying teleost sexdetermination and allow practical applications to genetically sex Atlantic cod. publishedVersion nivå1 Article in Journal/Newspaper atlantic cod Gadus morhua Unvieristy of Agder: AURA (Brage) Scientific Reports 6 1 |
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Unvieristy of Agder: AURA (Brage) |
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English |
description |
A variety of sex determination mechanisms can be observed in evolutionary divergent teleosts. Sex determination is genetic in Atlantic cod (Gadus morhua), however the genomic location or size of its sex-locus is unknown. Here, we characterize the sex-locus of Atlantic cod using whole genome sequence (WGS) data of 227 wild-caught specimens. Analyzing more than 55 million polymorphic loci, we identify 166 loci that are associated with sex. These loci are located in six distinct regions on fve diferent linkage groups (LG) in the genome. The largest of these regions, an approximately 55Kb region on LG11, contains the majority of genotypes that segregate closely according to a XX-XY system. Genotypes in this region can be used genetically determine sex, whereas those in the other regions are inconsistently sex-linked. The identifed region on LG11 and its surrounding genes have no clear sequence homology with genes or regulatory elements associated with sex-determination or diferentiation in other species. The functionality of this sex-locus therefore remains unknown. The WGS strategy used here proved adequate for detecting the small regions associated with sex in this species. Our results highlight the evolutionary fexibility in genomic architecture underlying teleost sexdetermination and allow practical applications to genetically sex Atlantic cod. publishedVersion nivå1 |
format |
Article in Journal/Newspaper |
author |
Star, Bastiaan Tørresen, Ole Kristian Nederbragt, Alexander Johan Jakobsen, Kjetill Sigurd Pampoulie, Christophe Jentoft, Sissel |
spellingShingle |
Star, Bastiaan Tørresen, Ole Kristian Nederbragt, Alexander Johan Jakobsen, Kjetill Sigurd Pampoulie, Christophe Jentoft, Sissel Genomic characterization of the Atlantic cod sex-locus |
author_facet |
Star, Bastiaan Tørresen, Ole Kristian Nederbragt, Alexander Johan Jakobsen, Kjetill Sigurd Pampoulie, Christophe Jentoft, Sissel |
author_sort |
Star, Bastiaan |
title |
Genomic characterization of the Atlantic cod sex-locus |
title_short |
Genomic characterization of the Atlantic cod sex-locus |
title_full |
Genomic characterization of the Atlantic cod sex-locus |
title_fullStr |
Genomic characterization of the Atlantic cod sex-locus |
title_full_unstemmed |
Genomic characterization of the Atlantic cod sex-locus |
title_sort |
genomic characterization of the atlantic cod sex-locus |
publisher |
Nature Publishing |
publishDate |
2016 |
url |
http://hdl.handle.net/11250/2484959 https://doi.org/10.1038/srep31235 |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_source |
1-9 6 Scientific Reports |
op_relation |
Norges forskningsråd: 179569 Norges forskningsråd: 221734 Norges forskningsråd: 203850 Notur/NorStore: nn9244k Scientific Reports. 2016, 6 1-9. urn:issn:2045-2322 http://hdl.handle.net/11250/2484959 https://doi.org/10.1038/srep31235 cristin:1375905 |
op_rights |
Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/srep31235 |
container_title |
Scientific Reports |
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6 |
container_issue |
1 |
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1766357312949190656 |