Antifertility Effects Of Single Oral Doses Of Triptolide In Male House Rat (Rattus Rattus L.)

• Main Author: Singla , Neena
• Format: Article in Journal/Newspaper
• Language: English
• Published: ACS Publisher 2014
• Subjects: Antifertility; Rattus rattus; single dose; triptolide
• Online Access: https://acspublisher.com/journals/index.php/abr/article/view/12307

The aim of present study was to evaluate the effect of single oral doses of triptolide on fertility of male house rat, Rattus rattus. Single oraladministration of triptolide to male R. rattus resulted in 16.67 and 33.33%mortality in rats treated with 100 and 150 mg kg-1b.wt. of triptolide,respectively, within 1-3 days of treatment. The LD50 value of triptolideagainst male R. rattus was found to be 182.81 mg kg-1 b.wt. Autopsy of ratssurviving till day 45 after treatment revealed no significant effect onweights of reproductive organs. The sperm motility and viability in caudaepididymal fluid were reduced significantly in all the treated groups.Sperm concentration was significantly reduced only in rats treated with100 mg kg-1 b.wt. of triptolide. Treatments significantly affected spermmorphology. The sperms with head tail separation ranged from 15.8 to24.0% in all treated groups. The present study suggests the potential oftriptolide in regulating fertility of male R. rattus.