Dicarbonylchloro(pentabenzylcyclopentadienyl)ruthenium as Racemization Catalyst in the Dynamic Kinetic Resolution of Secondary Alcohols

• Published in: European Journal of Organic Chemistry
• Main Authors: Mavrynsky, D, Paivio, M, Lundell, K, Sillanpaa, R, Kanerva, LT, Leino, Reko
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: 2009
• Subjects: Cyclopentadienyl ligands; Dynamic kinetic resolution; Enzyme catalysis; Racemization; Ruthenium; Antarc*; Antarctica
• Online Access: https://research.abo.fi/en/publications/f580f523-9686-4e37-9d73-6b2eefa6c350; https://doi.org/10.1002/ejoc.200801248

Dicarbonylchloro(pentabenzylcyclopentadienyl)ruthenium has been prepared and its structure confirmed by X-ray analysis, This complex shows excellent catalytic activity and modest stability against air in racemization reactions of secondary alcohols. In Candida antarctica lipase B (CAL-B) catalyzed dynamic kinetic resolution (DKR) of 1-phenyl- and 1-(furan-2-yl)ethanol compounds, the new complex shows improved performance as an alcohol racemization catalyst in comparison with its well-known pentaphenylcyclopentadienyl analogue, hitherto considered as the leading catalyst candidate. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)