Exposure of mallards (Anas platyrhynchos) to the hepatotoxic cyanobacterium Nodularia spumigena
Nodularin (NODLN) is a cyclic pentapeptide hepatotoxin produced by the cyanobacterium Nodularia spumigena, which forms extensive blooms during the summer in the Baltic Sea. Nodularin was detected in liver, muscle and/or feather samples of several common eiders (Somateria mollissima) from the Gulf of...
Published in: | Toxicological & Environmental Chemistry |
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Language: | English |
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2008
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Online Access: | https://research.abo.fi/en/publications/a2496857-0dfb-4cbf-8d38-de112016603d https://doi.org/10.1080/02772240701529103 http://www.scopus.com/inward/record.url?scp=47949128417&partnerID=8YFLogxK |
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ftaboakademicris:oai:pure.atira.dk:publications/a2496857-0dfb-4cbf-8d38-de112016603d 2023-05-15T18:20:27+02:00 Exposure of mallards (Anas platyrhynchos) to the hepatotoxic cyanobacterium Nodularia spumigena Sipiä, V. O. Franson, J. C. Sjövall, O. Pflugmacher, S. Shearn-Bochsler, V. Rocke, T. E. Meriluoto, J. A.O. 2008-05 https://research.abo.fi/en/publications/a2496857-0dfb-4cbf-8d38-de112016603d https://doi.org/10.1080/02772240701529103 http://www.scopus.com/inward/record.url?scp=47949128417&partnerID=8YFLogxK eng eng info:eu-repo/semantics/restrictedAccess Sipiä , V O , Franson , J C , Sjövall , O , Pflugmacher , S , Shearn-Bochsler , V , Rocke , T E & Meriluoto , J A O 2008 , ' Exposure of mallards (Anas platyrhynchos) to the hepatotoxic cyanobacterium Nodularia spumigena ' , Toxicological and Environmental Chemistry , vol. 90 , no. 3 , pp. 437-444 . https://doi.org/10.1080/02772240701529103 Bioaccumulation Mallards Nodularia spumigena Nodularin Toxicity article 2008 ftaboakademicris https://doi.org/10.1080/02772240701529103 2022-12-04T14:21:04Z Nodularin (NODLN) is a cyclic pentapeptide hepatotoxin produced by the cyanobacterium Nodularia spumigena, which forms extensive blooms during the summer in the Baltic Sea. Nodularin was detected in liver, muscle and/or feather samples of several common eiders (Somateria mollissima) from the Gulf of Finland (northern Baltic Sea) in 2002-2005. Published information on the adverse effects of NODLN in marine birds is scarce. The aim of this study was to evaluate the toxicity of NODLN, and determine the concentrations of NODLN in liver and muscle tissue in mallards (Anas platyrhynchos) exposed to N. spumigena. Mallards received a single or multiple exposure via oral gavage with an aqueous slurry containing toxic N. spumigena. Dosages ranged from 200 to 600 μg NODLN per kg body weight (bw). There were minimal histopathological changes in liver tissue, and brain cholinesterase activity did not differ among treatment groups. Concentrations of NODLN measured by LC-MS in liver varied between approximately 3-120 μg kg-1 dry weight (dw) and ducks receiving multiple exposures had significantly greater liver toxin levels than ducks receiving the two lowest single exposures. In muscle, NODLN concentrations were approximately 2-6 μg kg-1 dw, but did not differ significantly among exposure groups. This is the first in vivo lab study examining the effects and bioaccumulation of NODLN from N. spumigena in birds. The mallards in this study were resistant to adverse effects and did not bioaccumulate substantial levels of NODLN at the doses given. Article in Journal/Newspaper Somateria mollissima Åbo Akademi University Research Portal Toxicological & Environmental Chemistry 90 3 437 444 |
institution |
Open Polar |
collection |
Åbo Akademi University Research Portal |
op_collection_id |
ftaboakademicris |
language |
English |
topic |
Bioaccumulation Mallards Nodularia spumigena Nodularin Toxicity |
spellingShingle |
Bioaccumulation Mallards Nodularia spumigena Nodularin Toxicity Sipiä, V. O. Franson, J. C. Sjövall, O. Pflugmacher, S. Shearn-Bochsler, V. Rocke, T. E. Meriluoto, J. A.O. Exposure of mallards (Anas platyrhynchos) to the hepatotoxic cyanobacterium Nodularia spumigena |
topic_facet |
Bioaccumulation Mallards Nodularia spumigena Nodularin Toxicity |
description |
Nodularin (NODLN) is a cyclic pentapeptide hepatotoxin produced by the cyanobacterium Nodularia spumigena, which forms extensive blooms during the summer in the Baltic Sea. Nodularin was detected in liver, muscle and/or feather samples of several common eiders (Somateria mollissima) from the Gulf of Finland (northern Baltic Sea) in 2002-2005. Published information on the adverse effects of NODLN in marine birds is scarce. The aim of this study was to evaluate the toxicity of NODLN, and determine the concentrations of NODLN in liver and muscle tissue in mallards (Anas platyrhynchos) exposed to N. spumigena. Mallards received a single or multiple exposure via oral gavage with an aqueous slurry containing toxic N. spumigena. Dosages ranged from 200 to 600 μg NODLN per kg body weight (bw). There were minimal histopathological changes in liver tissue, and brain cholinesterase activity did not differ among treatment groups. Concentrations of NODLN measured by LC-MS in liver varied between approximately 3-120 μg kg-1 dry weight (dw) and ducks receiving multiple exposures had significantly greater liver toxin levels than ducks receiving the two lowest single exposures. In muscle, NODLN concentrations were approximately 2-6 μg kg-1 dw, but did not differ significantly among exposure groups. This is the first in vivo lab study examining the effects and bioaccumulation of NODLN from N. spumigena in birds. The mallards in this study were resistant to adverse effects and did not bioaccumulate substantial levels of NODLN at the doses given. |
format |
Article in Journal/Newspaper |
author |
Sipiä, V. O. Franson, J. C. Sjövall, O. Pflugmacher, S. Shearn-Bochsler, V. Rocke, T. E. Meriluoto, J. A.O. |
author_facet |
Sipiä, V. O. Franson, J. C. Sjövall, O. Pflugmacher, S. Shearn-Bochsler, V. Rocke, T. E. Meriluoto, J. A.O. |
author_sort |
Sipiä, V. O. |
title |
Exposure of mallards (Anas platyrhynchos) to the hepatotoxic cyanobacterium Nodularia spumigena |
title_short |
Exposure of mallards (Anas platyrhynchos) to the hepatotoxic cyanobacterium Nodularia spumigena |
title_full |
Exposure of mallards (Anas platyrhynchos) to the hepatotoxic cyanobacterium Nodularia spumigena |
title_fullStr |
Exposure of mallards (Anas platyrhynchos) to the hepatotoxic cyanobacterium Nodularia spumigena |
title_full_unstemmed |
Exposure of mallards (Anas platyrhynchos) to the hepatotoxic cyanobacterium Nodularia spumigena |
title_sort |
exposure of mallards (anas platyrhynchos) to the hepatotoxic cyanobacterium nodularia spumigena |
publishDate |
2008 |
url |
https://research.abo.fi/en/publications/a2496857-0dfb-4cbf-8d38-de112016603d https://doi.org/10.1080/02772240701529103 http://www.scopus.com/inward/record.url?scp=47949128417&partnerID=8YFLogxK |
genre |
Somateria mollissima |
genre_facet |
Somateria mollissima |
op_source |
Sipiä , V O , Franson , J C , Sjövall , O , Pflugmacher , S , Shearn-Bochsler , V , Rocke , T E & Meriluoto , J A O 2008 , ' Exposure of mallards (Anas platyrhynchos) to the hepatotoxic cyanobacterium Nodularia spumigena ' , Toxicological and Environmental Chemistry , vol. 90 , no. 3 , pp. 437-444 . https://doi.org/10.1080/02772240701529103 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1080/02772240701529103 |
container_title |
Toxicological & Environmental Chemistry |
container_volume |
90 |
container_issue |
3 |
container_start_page |
437 |
op_container_end_page |
444 |
_version_ |
1766197969928847360 |