DNA double-strand breaks in incubating female common eiders (Somateria mollissima): Comparison between a low and a high polluted area
Alterations in the genetic material may have severe consequences for individuals and populations. Hence, genotoxic effects of environmental exposure to pollutants are of great concern. We assessed the impact of blood concentrations of persistent organic pollutants (POPs) and mercury (Hg) on DNA doub...
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ftaboakademicris:oai:pure.atira.dk:publications/80354a2b-9b1a-4685-9fc3-a1093054b3c7 2024-04-28T08:08:09+00:00 DNA double-strand breaks in incubating female common eiders (Somateria mollissima): Comparison between a low and a high polluted area Fenstad, AA Bustnes, JO Bingham, CG Öst, Markus Jaatinen, K Moe, B Hanssen, SA Moody, AJ Gabrielsen, KM Herzke, D Lierhagen, S Jenssen, BM Krokje, A 2016 https://research.abo.fi/en/publications/80354a2b-9b1a-4685-9fc3-a1093054b3c7 https://doi.org/10.1016/j.envres.2016.07.031 und unknown https://research.abo.fi/en/publications/80354a2b-9b1a-4685-9fc3-a1093054b3c7 info:eu-repo/semantics/restrictedAccess Fenstad , AA , Bustnes , JO , Bingham , CG , Öst , M , Jaatinen , K , Moe , B , Hanssen , SA , Moody , AJ , Gabrielsen , KM , Herzke , D , Lierhagen , S , Jenssen , BM & Krokje , A 2016 , ' DNA double-strand breaks in incubating female common eiders (Somateria mollissima): Comparison between a low and a high polluted area ' , Environmental Research , vol. 151 , pp. 297–303 . https://doi.org/10.1016/j.envres.2016.07.031 Genotoxicity Mercury p,p '-DDE PCB Seabirds article 2016 ftaboakademicris https://doi.org/10.1016/j.envres.2016.07.031 2024-04-02T16:55:37Z Alterations in the genetic material may have severe consequences for individuals and populations. Hence, genotoxic effects of environmental exposure to pollutants are of great concern. We assessed the impact of blood concentrations of persistent organic pollutants (POPs) and mercury (Hg) on DNA double strand break (DSB) frequency, in blood cells of a high-exposed Baltic, and lower exposed Arctic population of common eiders (Somateria mollissima). Furthermore, we examined whether the genotoxic response was influenced by antioxidant concentration (plasma total glutathione (tGSH) and total antioxidant capacity) and female body mass. The DNA DSB frequency did not differ between the two populations. We found significant positive relationships between Hg and DNA DSB frequency in Baltic, but not in Arctic eiders. Although both p,p'-DDE and PCB 118 had a lesser effect than Hg, they exhibited a positive association with DNA DSB frequency in Baltic eiders. Antioxidant levels were not important for the genotoxic effect, suggesting alternative mechanisms other than GSH depletion for the relationship between Hg and DNA DSBs. Hence, the Baltic population, which is considered to be endangered and is under the influence of several environmental stressors, may be more susceptible to genotoxic effects of environmental exposure to Hg than the Arctic population. Article in Journal/Newspaper Arctic Arctic Population Somateria mollissima Åbo Akademi University Research Portal Environmental Research 151 297 303 |
institution |
Open Polar |
collection |
Åbo Akademi University Research Portal |
op_collection_id |
ftaboakademicris |
language |
unknown |
topic |
Genotoxicity Mercury p,p '-DDE PCB Seabirds |
spellingShingle |
Genotoxicity Mercury p,p '-DDE PCB Seabirds Fenstad, AA Bustnes, JO Bingham, CG Öst, Markus Jaatinen, K Moe, B Hanssen, SA Moody, AJ Gabrielsen, KM Herzke, D Lierhagen, S Jenssen, BM Krokje, A DNA double-strand breaks in incubating female common eiders (Somateria mollissima): Comparison between a low and a high polluted area |
topic_facet |
Genotoxicity Mercury p,p '-DDE PCB Seabirds |
description |
Alterations in the genetic material may have severe consequences for individuals and populations. Hence, genotoxic effects of environmental exposure to pollutants are of great concern. We assessed the impact of blood concentrations of persistent organic pollutants (POPs) and mercury (Hg) on DNA double strand break (DSB) frequency, in blood cells of a high-exposed Baltic, and lower exposed Arctic population of common eiders (Somateria mollissima). Furthermore, we examined whether the genotoxic response was influenced by antioxidant concentration (plasma total glutathione (tGSH) and total antioxidant capacity) and female body mass. The DNA DSB frequency did not differ between the two populations. We found significant positive relationships between Hg and DNA DSB frequency in Baltic, but not in Arctic eiders. Although both p,p'-DDE and PCB 118 had a lesser effect than Hg, they exhibited a positive association with DNA DSB frequency in Baltic eiders. Antioxidant levels were not important for the genotoxic effect, suggesting alternative mechanisms other than GSH depletion for the relationship between Hg and DNA DSBs. Hence, the Baltic population, which is considered to be endangered and is under the influence of several environmental stressors, may be more susceptible to genotoxic effects of environmental exposure to Hg than the Arctic population. |
format |
Article in Journal/Newspaper |
author |
Fenstad, AA Bustnes, JO Bingham, CG Öst, Markus Jaatinen, K Moe, B Hanssen, SA Moody, AJ Gabrielsen, KM Herzke, D Lierhagen, S Jenssen, BM Krokje, A |
author_facet |
Fenstad, AA Bustnes, JO Bingham, CG Öst, Markus Jaatinen, K Moe, B Hanssen, SA Moody, AJ Gabrielsen, KM Herzke, D Lierhagen, S Jenssen, BM Krokje, A |
author_sort |
Fenstad, AA |
title |
DNA double-strand breaks in incubating female common eiders (Somateria mollissima): Comparison between a low and a high polluted area |
title_short |
DNA double-strand breaks in incubating female common eiders (Somateria mollissima): Comparison between a low and a high polluted area |
title_full |
DNA double-strand breaks in incubating female common eiders (Somateria mollissima): Comparison between a low and a high polluted area |
title_fullStr |
DNA double-strand breaks in incubating female common eiders (Somateria mollissima): Comparison between a low and a high polluted area |
title_full_unstemmed |
DNA double-strand breaks in incubating female common eiders (Somateria mollissima): Comparison between a low and a high polluted area |
title_sort |
dna double-strand breaks in incubating female common eiders (somateria mollissima): comparison between a low and a high polluted area |
publishDate |
2016 |
url |
https://research.abo.fi/en/publications/80354a2b-9b1a-4685-9fc3-a1093054b3c7 https://doi.org/10.1016/j.envres.2016.07.031 |
genre |
Arctic Arctic Population Somateria mollissima |
genre_facet |
Arctic Arctic Population Somateria mollissima |
op_source |
Fenstad , AA , Bustnes , JO , Bingham , CG , Öst , M , Jaatinen , K , Moe , B , Hanssen , SA , Moody , AJ , Gabrielsen , KM , Herzke , D , Lierhagen , S , Jenssen , BM & Krokje , A 2016 , ' DNA double-strand breaks in incubating female common eiders (Somateria mollissima): Comparison between a low and a high polluted area ' , Environmental Research , vol. 151 , pp. 297–303 . https://doi.org/10.1016/j.envres.2016.07.031 |
op_relation |
https://research.abo.fi/en/publications/80354a2b-9b1a-4685-9fc3-a1093054b3c7 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1016/j.envres.2016.07.031 |
container_title |
Environmental Research |
container_volume |
151 |
container_start_page |
297 |
op_container_end_page |
303 |
_version_ |
1797577059953803264 |