Patient-specific and healthcare real-world costs of atrial fibrillation in individuals treated with direct oral anticoagulant agents or warfarin
Background: Anticoagulant therapies are used to prevent atrial fibrillation-related strokes, with warfarin and direct oral anticoagulant (DOAC) the most common. In this study, we incorporate direct health care costs, drug costs, travel costs, and lost working and leisure time costs to estimate the t...
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ftaaltouniv:oai:aaltodoc.aalto.fi:123456789/111645 2023-05-15T17:00:14+02:00 Patient-specific and healthcare real-world costs of atrial fibrillation in individuals treated with direct oral anticoagulant agents or warfarin Pyykonen, Mikko Linna, Miika Tykkylainen, Markku Delmelle, Eric Laatikainen, Tiina University of Eastern Finland Department of Industrial Engineering and Management Aalto-yliopisto Aalto University 2021-12-03 application/pdf https://aaltodoc.aalto.fi/handle/123456789/111645 https://doi.org/10.1186/s12913-021-07125-5 en eng BioMed Central BMC HEALTH SERVICES RESEARCH Volume 21, issue 1 Pyykonen , M , Linna , M , Tykkylainen , M , Delmelle , E & Laatikainen , T 2021 , ' Patient-specific and healthcare real-world costs of atrial fibrillation in individuals treated with direct oral anticoagulant agents or warfarin ' , BMC HEALTH SERVICES RESEARCH , vol. 21 , no. 1 , 1299 . https://doi.org/10.1186/s12913-021-07125-5 1472-6963 PURE UUID: cffd057c-b6e8-444c-abb2-a8ba92fe8237 PURE ITEMURL: https://research.aalto.fi/en/publications/cffd057c-b6e8-444c-abb2-a8ba92fe8237 PURE LINK: http://www.scopus.com/inward/record.url?scp=85120743688&partnerID=8YFLogxK PURE FILEURL: https://research.aalto.fi/files/76676728/Patient_specific_and_healthcare_real_world_costs_of_atrial_fibrillation_in_individuals_treated_with_direct_oral_anticoagulant_agents_or_warfarin.pdf https://aaltodoc.aalto.fi/handle/123456789/111645 URN:NBN:fi:aalto-2021121510786 doi:10.1186/s12913-021-07125-5 openAccess Real-world data GIS Time and travel costs Cost model Electronic health records EPIDEMIOLOGY TRENDS DABIGATRAN CHOICE TRAVEL A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä publishedVersion 2021 ftaaltouniv https://doi.org/10.1186/s12913-021-07125-5 2022-12-15T19:34:03Z Background: Anticoagulant therapies are used to prevent atrial fibrillation-related strokes, with warfarin and direct oral anticoagulant (DOAC) the most common. In this study, we incorporate direct health care costs, drug costs, travel costs, and lost working and leisure time costs to estimate the total costs of the two therapies. Methods: This retrospective study used individual-level patient data from 4000 atrial fibrillation (AF) patients from North Karelia, Finland. Real-world data on healthcare use was obtained from the regional patient information system and data on reimbursed travel costs from the database of the Social Insurance Institution of Finland. The costs of the therapies were estimated between June 2017 and May 2018. Using a Geographical Information System (GIS), we estimated travel time and costs for each journey related to anticoagulant therapies. We ultimately applied therapy and travel costs to a cost model to reflect real-world expenditures. Results: The costs of anticoagulant therapies were calculated from the standpoint of patient and the healthcare service when considering all costs from AF-related healthcare visits, including major complications arising from atrial fibrillation. On average, the annual cost per patient for healthcare in the form of public expenditure was higher when using DOAC therapy than warfarin therapy (average cost = € 927 vs. € 805). Additionally, the average annual cost for patients was also higher with DOAC therapy (average cost = € 406.5 vs. € 296.7). In warfarin therapy, patients had considerable more travel and time costs due the different implementation practices of therapies. Conclusion: The results indicated that DOAC therapy had higher costs over warfarin from the perspectives of the patient and healthcare service in the study area on average. Currently, the cost of the DOAC drug is the largest determinator of total therapy costs from both perspectives. Despite slightly higher costs, the patients on DOAC therapy experienced less AF-related complications ... Article in Journal/Newspaper karelia* Aalto University Publication Archive (Aaltodoc) BMC Health Services Research 21 1 |
institution |
Open Polar |
collection |
Aalto University Publication Archive (Aaltodoc) |
op_collection_id |
ftaaltouniv |
language |
English |
topic |
Real-world data GIS Time and travel costs Cost model Electronic health records EPIDEMIOLOGY TRENDS DABIGATRAN CHOICE TRAVEL |
spellingShingle |
Real-world data GIS Time and travel costs Cost model Electronic health records EPIDEMIOLOGY TRENDS DABIGATRAN CHOICE TRAVEL Pyykonen, Mikko Linna, Miika Tykkylainen, Markku Delmelle, Eric Laatikainen, Tiina Patient-specific and healthcare real-world costs of atrial fibrillation in individuals treated with direct oral anticoagulant agents or warfarin |
topic_facet |
Real-world data GIS Time and travel costs Cost model Electronic health records EPIDEMIOLOGY TRENDS DABIGATRAN CHOICE TRAVEL |
description |
Background: Anticoagulant therapies are used to prevent atrial fibrillation-related strokes, with warfarin and direct oral anticoagulant (DOAC) the most common. In this study, we incorporate direct health care costs, drug costs, travel costs, and lost working and leisure time costs to estimate the total costs of the two therapies. Methods: This retrospective study used individual-level patient data from 4000 atrial fibrillation (AF) patients from North Karelia, Finland. Real-world data on healthcare use was obtained from the regional patient information system and data on reimbursed travel costs from the database of the Social Insurance Institution of Finland. The costs of the therapies were estimated between June 2017 and May 2018. Using a Geographical Information System (GIS), we estimated travel time and costs for each journey related to anticoagulant therapies. We ultimately applied therapy and travel costs to a cost model to reflect real-world expenditures. Results: The costs of anticoagulant therapies were calculated from the standpoint of patient and the healthcare service when considering all costs from AF-related healthcare visits, including major complications arising from atrial fibrillation. On average, the annual cost per patient for healthcare in the form of public expenditure was higher when using DOAC therapy than warfarin therapy (average cost = € 927 vs. € 805). Additionally, the average annual cost for patients was also higher with DOAC therapy (average cost = € 406.5 vs. € 296.7). In warfarin therapy, patients had considerable more travel and time costs due the different implementation practices of therapies. Conclusion: The results indicated that DOAC therapy had higher costs over warfarin from the perspectives of the patient and healthcare service in the study area on average. Currently, the cost of the DOAC drug is the largest determinator of total therapy costs from both perspectives. Despite slightly higher costs, the patients on DOAC therapy experienced less AF-related complications ... |
author2 |
University of Eastern Finland Department of Industrial Engineering and Management Aalto-yliopisto Aalto University |
format |
Article in Journal/Newspaper |
author |
Pyykonen, Mikko Linna, Miika Tykkylainen, Markku Delmelle, Eric Laatikainen, Tiina |
author_facet |
Pyykonen, Mikko Linna, Miika Tykkylainen, Markku Delmelle, Eric Laatikainen, Tiina |
author_sort |
Pyykonen, Mikko |
title |
Patient-specific and healthcare real-world costs of atrial fibrillation in individuals treated with direct oral anticoagulant agents or warfarin |
title_short |
Patient-specific and healthcare real-world costs of atrial fibrillation in individuals treated with direct oral anticoagulant agents or warfarin |
title_full |
Patient-specific and healthcare real-world costs of atrial fibrillation in individuals treated with direct oral anticoagulant agents or warfarin |
title_fullStr |
Patient-specific and healthcare real-world costs of atrial fibrillation in individuals treated with direct oral anticoagulant agents or warfarin |
title_full_unstemmed |
Patient-specific and healthcare real-world costs of atrial fibrillation in individuals treated with direct oral anticoagulant agents or warfarin |
title_sort |
patient-specific and healthcare real-world costs of atrial fibrillation in individuals treated with direct oral anticoagulant agents or warfarin |
publisher |
BioMed Central |
publishDate |
2021 |
url |
https://aaltodoc.aalto.fi/handle/123456789/111645 https://doi.org/10.1186/s12913-021-07125-5 |
genre |
karelia* |
genre_facet |
karelia* |
op_relation |
BMC HEALTH SERVICES RESEARCH Volume 21, issue 1 Pyykonen , M , Linna , M , Tykkylainen , M , Delmelle , E & Laatikainen , T 2021 , ' Patient-specific and healthcare real-world costs of atrial fibrillation in individuals treated with direct oral anticoagulant agents or warfarin ' , BMC HEALTH SERVICES RESEARCH , vol. 21 , no. 1 , 1299 . https://doi.org/10.1186/s12913-021-07125-5 1472-6963 PURE UUID: cffd057c-b6e8-444c-abb2-a8ba92fe8237 PURE ITEMURL: https://research.aalto.fi/en/publications/cffd057c-b6e8-444c-abb2-a8ba92fe8237 PURE LINK: http://www.scopus.com/inward/record.url?scp=85120743688&partnerID=8YFLogxK PURE FILEURL: https://research.aalto.fi/files/76676728/Patient_specific_and_healthcare_real_world_costs_of_atrial_fibrillation_in_individuals_treated_with_direct_oral_anticoagulant_agents_or_warfarin.pdf https://aaltodoc.aalto.fi/handle/123456789/111645 URN:NBN:fi:aalto-2021121510786 doi:10.1186/s12913-021-07125-5 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1186/s12913-021-07125-5 |
container_title |
BMC Health Services Research |
container_volume |
21 |
container_issue |
1 |
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