The Impact of Divergence Time on the Nature of Population Structure: An Example from Iceland
The Icelandic population has been sampled in many disease association studies, providing a strong motivation to understand the structure of this population and its ramifications for disease gene mapping. Previous work using 40 microsatellites showed that the Icelandic population is relatively homoge...
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dataone:sha256:ac87efe184b6cbf9561cf110dee1f61b31a41f051db66c8beebe4ae91bcac7ff 2024-06-03T18:46:57+00:00 The Impact of Divergence Time on the Nature of Population Structure: An Example from Iceland Alkes L. Price Agnar Helgason Snaebjorn Palsson Hreinn Stefansson David St. Clair Ole A. Andreassen David Reich Augustine Kong Kari Stefansson 2010-10-26T00:00:00Z https://search.dataone.org/view/sha256:ac87efe184b6cbf9561cf110dee1f61b31a41f051db66c8beebe4ae91bcac7ff unknown Statistical Genetics, Genomics, and Omics Dataset 2010 dataone:urn:node:HD 2024-06-03T18:07:22Z The Icelandic population has been sampled in many disease association studies, providing a strong motivation to understand the structure of this population and its ramifications for disease gene mapping. Previous work using 40 microsatellites showed that the Icelandic population is relatively homogeneous, but exhibits subtle population structure that can bias disease association statistics. Here, we show that regional geographic ancestries of individuals from Iceland can be distinguished using 292,289 autosomal single-nucleotide polymorphisms (SNPs). We further show that subpopulation differences are due to genetic drift since the settlement of Iceland 1100 years ago, and not to varying contributions from different ancestral populations. A consequence of the recent origin of Icelandic population structure is that allele frequency differences follow a null distribution devoid of outliers, so that the risk of false positive associations due to stratification is minimal. Our results highlight an important distinction between population differences attributable to recent drift and those arising from more ancient divergence, which has implications both for association studies and for efforts to detect natural selection using population differentiation. Dataset Iceland Unknown |
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Statistical Genetics, Genomics, and Omics |
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Statistical Genetics, Genomics, and Omics Alkes L. Price Agnar Helgason Snaebjorn Palsson Hreinn Stefansson David St. Clair Ole A. Andreassen David Reich Augustine Kong Kari Stefansson The Impact of Divergence Time on the Nature of Population Structure: An Example from Iceland |
topic_facet |
Statistical Genetics, Genomics, and Omics |
description |
The Icelandic population has been sampled in many disease association studies, providing a strong motivation to understand the structure of this population and its ramifications for disease gene mapping. Previous work using 40 microsatellites showed that the Icelandic population is relatively homogeneous, but exhibits subtle population structure that can bias disease association statistics. Here, we show that regional geographic ancestries of individuals from Iceland can be distinguished using 292,289 autosomal single-nucleotide polymorphisms (SNPs). We further show that subpopulation differences are due to genetic drift since the settlement of Iceland 1100 years ago, and not to varying contributions from different ancestral populations. A consequence of the recent origin of Icelandic population structure is that allele frequency differences follow a null distribution devoid of outliers, so that the risk of false positive associations due to stratification is minimal. Our results highlight an important distinction between population differences attributable to recent drift and those arising from more ancient divergence, which has implications both for association studies and for efforts to detect natural selection using population differentiation. |
format |
Dataset |
author |
Alkes L. Price Agnar Helgason Snaebjorn Palsson Hreinn Stefansson David St. Clair Ole A. Andreassen David Reich Augustine Kong Kari Stefansson |
author_facet |
Alkes L. Price Agnar Helgason Snaebjorn Palsson Hreinn Stefansson David St. Clair Ole A. Andreassen David Reich Augustine Kong Kari Stefansson |
author_sort |
Alkes L. Price |
title |
The Impact of Divergence Time on the Nature of Population Structure: An Example from Iceland |
title_short |
The Impact of Divergence Time on the Nature of Population Structure: An Example from Iceland |
title_full |
The Impact of Divergence Time on the Nature of Population Structure: An Example from Iceland |
title_fullStr |
The Impact of Divergence Time on the Nature of Population Structure: An Example from Iceland |
title_full_unstemmed |
The Impact of Divergence Time on the Nature of Population Structure: An Example from Iceland |
title_sort |
impact of divergence time on the nature of population structure: an example from iceland |
publishDate |
2010 |
url |
https://search.dataone.org/view/sha256:ac87efe184b6cbf9561cf110dee1f61b31a41f051db66c8beebe4ae91bcac7ff |
genre |
Iceland |
genre_facet |
Iceland |
_version_ |
1800873614325579776 |