Adrenergic and adenosinergic regulation of the cardiovascular system in the Antarctic icefish Chaenocephalus aceratus
Abstract: Icefishes characteristically lack the oxygen-binding protein haemoglobin and therefore are especially reliant on cardiovascular regulation to augment oxygen transport when oxygen demand increases, such as during activity and warming. Using both in vivo and in vitro experiments, we evaluate...
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IEDA: US Antarctic Program Data Center
2020
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dataone:http://get.iedadata.org/metadata/iso/601409 2024-06-03T18:46:23+00:00 Adrenergic and adenosinergic regulation of the cardiovascular system in the Antarctic icefish Chaenocephalus aceratus Axelsson, Michael Egginton, Stuart Farrell, Anthony Joyce, Michael O'Brien, Kristin BEGINDATE: 2014-09-01T00:00:00Z ENDDATE: 2019-08-31T00:00:00Z 2020-12-18T00:00:00Z http://get.iedadata.org/metadata/iso/601409 unknown IEDA: US Antarctic Program Data Center Cryosphere Antarctica Antarctic Peninsula US Antarctic Program Data Center (USAP-DC) Dataset 2020 dataone:urn:node:IEDA_USAP 2024-06-03T18:17:00Z Abstract: Icefishes characteristically lack the oxygen-binding protein haemoglobin and therefore are especially reliant on cardiovascular regulation to augment oxygen transport when oxygen demand increases, such as during activity and warming. Using both in vivo and in vitro experiments, we evaluated the roles for adrenaline and adenosine, two well-established cardio- and vasoactive molecules, in regulating the cardiovascular system of the blackfin icefish, Chaenocephalus aceratus. Despite increasing cardiac contractility (increasing twitch force and contraction kinetics in isometric myocardial strip preparations) and accelerating heart rate (ƒH), adrenaline (5 nmol kg-1 bolus intra-arterial injection) did not significantly increase cardiac output (Q̇) in vivo because it elicited a large decrease in vascular conductance (Gsys). In contrast, and despite preliminary data suggesting a direct negative inotropic effect of adenosine on isolated atria and little effect on isolated ventricle strips, adenosine (500 nmol kg-1) generated a large increase in Q̇ by increasing Gsys, a change reminiscent of that previously reported during both acute warming and invoked activity. Our data thus illustrate how Q̇ in C. aceratus may be much more dependent on peripheral control of vasomotor tone than direct regulation of the heart. Dataset Antarc* Antarctic Antarctic Peninsula Antarctica Icefish IEDA: US Antarctic Program Data Center (via DataONE) Antarctic Antarctic Peninsula The Antarctic |
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Open Polar |
collection |
IEDA: US Antarctic Program Data Center (via DataONE) |
op_collection_id |
dataone:urn:node:IEDA_USAP |
language |
unknown |
topic |
Cryosphere Antarctica Antarctic Peninsula US Antarctic Program Data Center (USAP-DC) |
spellingShingle |
Cryosphere Antarctica Antarctic Peninsula US Antarctic Program Data Center (USAP-DC) Axelsson, Michael Egginton, Stuart Farrell, Anthony Joyce, Michael O'Brien, Kristin Adrenergic and adenosinergic regulation of the cardiovascular system in the Antarctic icefish Chaenocephalus aceratus |
topic_facet |
Cryosphere Antarctica Antarctic Peninsula US Antarctic Program Data Center (USAP-DC) |
description |
Abstract: Icefishes characteristically lack the oxygen-binding protein haemoglobin and therefore are especially reliant on cardiovascular regulation to augment oxygen transport when oxygen demand increases, such as during activity and warming. Using both in vivo and in vitro experiments, we evaluated the roles for adrenaline and adenosine, two well-established cardio- and vasoactive molecules, in regulating the cardiovascular system of the blackfin icefish, Chaenocephalus aceratus. Despite increasing cardiac contractility (increasing twitch force and contraction kinetics in isometric myocardial strip preparations) and accelerating heart rate (ƒH), adrenaline (5 nmol kg-1 bolus intra-arterial injection) did not significantly increase cardiac output (Q̇) in vivo because it elicited a large decrease in vascular conductance (Gsys). In contrast, and despite preliminary data suggesting a direct negative inotropic effect of adenosine on isolated atria and little effect on isolated ventricle strips, adenosine (500 nmol kg-1) generated a large increase in Q̇ by increasing Gsys, a change reminiscent of that previously reported during both acute warming and invoked activity. Our data thus illustrate how Q̇ in C. aceratus may be much more dependent on peripheral control of vasomotor tone than direct regulation of the heart. |
format |
Dataset |
author |
Axelsson, Michael Egginton, Stuart Farrell, Anthony Joyce, Michael O'Brien, Kristin |
author_facet |
Axelsson, Michael Egginton, Stuart Farrell, Anthony Joyce, Michael O'Brien, Kristin |
author_sort |
Axelsson, Michael |
title |
Adrenergic and adenosinergic regulation of the cardiovascular system in the Antarctic icefish Chaenocephalus aceratus |
title_short |
Adrenergic and adenosinergic regulation of the cardiovascular system in the Antarctic icefish Chaenocephalus aceratus |
title_full |
Adrenergic and adenosinergic regulation of the cardiovascular system in the Antarctic icefish Chaenocephalus aceratus |
title_fullStr |
Adrenergic and adenosinergic regulation of the cardiovascular system in the Antarctic icefish Chaenocephalus aceratus |
title_full_unstemmed |
Adrenergic and adenosinergic regulation of the cardiovascular system in the Antarctic icefish Chaenocephalus aceratus |
title_sort |
adrenergic and adenosinergic regulation of the cardiovascular system in the antarctic icefish chaenocephalus aceratus |
publisher |
IEDA: US Antarctic Program Data Center |
publishDate |
2020 |
url |
http://get.iedadata.org/metadata/iso/601409 |
op_coverage |
BEGINDATE: 2014-09-01T00:00:00Z ENDDATE: 2019-08-31T00:00:00Z |
geographic |
Antarctic Antarctic Peninsula The Antarctic |
geographic_facet |
Antarctic Antarctic Peninsula The Antarctic |
genre |
Antarc* Antarctic Antarctic Peninsula Antarctica Icefish |
genre_facet |
Antarc* Antarctic Antarctic Peninsula Antarctica Icefish |
_version_ |
1800871228093759488 |