Effects of Cholinergic Receptor Activation and Magnetic Fields on Motor Behavior in Ischemic Gerbils
Aim of the study: Given the known synergistic relationship between magnetic field (MF) and cholinergic receptor activation in the cholinergic system, the present study aims to investigate whether the combined use of a static MF and an agonist for nicotinic acetylcholine receptors (nAChR) can preserv...
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2023
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Online Access: | http://dx.doi.org/10.22541/au.167904556.64308282/v1 |
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crwinnower:10.22541/au.167904556.64308282/v1 2024-06-02T08:14:34+00:00 Effects of Cholinergic Receptor Activation and Magnetic Fields on Motor Behavior in Ischemic Gerbils Pitta, Manoela Zhang, Kelly Santo, Lucas Rosa, Gustavo de Mello Guirro, Elaine Araujo, João De 2023 http://dx.doi.org/10.22541/au.167904556.64308282/v1 unknown Authorea, Inc. posted-content 2023 crwinnower https://doi.org/10.22541/au.167904556.64308282/v1 2024-05-07T14:19:10Z Aim of the study: Given the known synergistic relationship between magnetic field (MF) and cholinergic receptor activation in the cholinergic system, the present study aims to investigate whether the combined use of a static MF and an agonist for nicotinic acetylcholine receptors (nAChR) can preserve motor behavior in ischemic gerbils. Materials & methods: We randomly allocated 72 Mongolian gerbils into nine groups (n=8), distributed according to surgical procedure and treatment. The animals were trained and evaluated on the Rotarod (RR) to assess motor performance. Results: Our main finding was the preservation of motor behavior in the Sham Ischemia + Nicotine + Sham Magnetic Stimulation (Sh+N+SMS) and Ischemia + Nicotine + South Pole (I+N+SP) groups, as evidenced by the results of the RR test. Conclusions: Our findings are consistent with previous literature and provide insight into the mechanism of potentiation, as results showed that adding a nAChR agonist to the MF preserved motor performance in the RR test of ischemic animals. Other/Unknown Material South pole The Winnower South Pole |
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Aim of the study: Given the known synergistic relationship between magnetic field (MF) and cholinergic receptor activation in the cholinergic system, the present study aims to investigate whether the combined use of a static MF and an agonist for nicotinic acetylcholine receptors (nAChR) can preserve motor behavior in ischemic gerbils. Materials & methods: We randomly allocated 72 Mongolian gerbils into nine groups (n=8), distributed according to surgical procedure and treatment. The animals were trained and evaluated on the Rotarod (RR) to assess motor performance. Results: Our main finding was the preservation of motor behavior in the Sham Ischemia + Nicotine + Sham Magnetic Stimulation (Sh+N+SMS) and Ischemia + Nicotine + South Pole (I+N+SP) groups, as evidenced by the results of the RR test. Conclusions: Our findings are consistent with previous literature and provide insight into the mechanism of potentiation, as results showed that adding a nAChR agonist to the MF preserved motor performance in the RR test of ischemic animals. |
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Other/Unknown Material |
author |
Pitta, Manoela Zhang, Kelly Santo, Lucas Rosa, Gustavo de Mello Guirro, Elaine Araujo, João De |
spellingShingle |
Pitta, Manoela Zhang, Kelly Santo, Lucas Rosa, Gustavo de Mello Guirro, Elaine Araujo, João De Effects of Cholinergic Receptor Activation and Magnetic Fields on Motor Behavior in Ischemic Gerbils |
author_facet |
Pitta, Manoela Zhang, Kelly Santo, Lucas Rosa, Gustavo de Mello Guirro, Elaine Araujo, João De |
author_sort |
Pitta, Manoela |
title |
Effects of Cholinergic Receptor Activation and Magnetic Fields on Motor Behavior in Ischemic Gerbils |
title_short |
Effects of Cholinergic Receptor Activation and Magnetic Fields on Motor Behavior in Ischemic Gerbils |
title_full |
Effects of Cholinergic Receptor Activation and Magnetic Fields on Motor Behavior in Ischemic Gerbils |
title_fullStr |
Effects of Cholinergic Receptor Activation and Magnetic Fields on Motor Behavior in Ischemic Gerbils |
title_full_unstemmed |
Effects of Cholinergic Receptor Activation and Magnetic Fields on Motor Behavior in Ischemic Gerbils |
title_sort |
effects of cholinergic receptor activation and magnetic fields on motor behavior in ischemic gerbils |
publisher |
Authorea, Inc. |
publishDate |
2023 |
url |
http://dx.doi.org/10.22541/au.167904556.64308282/v1 |
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geographic_facet |
South Pole |
genre |
South pole |
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South pole |
op_doi |
https://doi.org/10.22541/au.167904556.64308282/v1 |
_version_ |
1800738484994965504 |