Cost‐effectiveness of human papilloma virus vaccination in Iceland
Abstract Objective. To evaluate the likely cost‐effectiveness of introducing routine HPV vaccination in Iceland. Design. Prospective cost‐effectiveness analysis of human papilloma virus (HPV) vaccination. Setting and sample. Population of 12‐year‐old girls in the Icelandic population. Methods. A mod...
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crwiley:10.3109/00016340903322750 2023-12-03T10:24:39+01:00 Cost‐effectiveness of human papilloma virus vaccination in Iceland ODDSSON, KRISTJAN JOHANNSSON, JAKOB ASGEIRSDOTTIR, TINNA LAUFEY GUDNASON, THOROLFUR 2009 http://dx.doi.org/10.3109/00016340903322750 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.3109%2F00016340903322750 https://obgyn.onlinelibrary.wiley.com/doi/pdf/10.3109/00016340903322750 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Acta Obstetricia et Gynecologica Scandinavica volume 88, issue 12, page 1411-1416 ISSN 0001-6349 1600-0412 Obstetrics and Gynecology General Medicine journal-article 2009 crwiley https://doi.org/10.3109/00016340903322750 2023-11-09T13:23:25Z Abstract Objective. To evaluate the likely cost‐effectiveness of introducing routine HPV vaccination in Iceland. Design. Prospective cost‐effectiveness analysis of human papilloma virus (HPV) vaccination. Setting and sample. Population of 12‐year‐old girls in the Icelandic population. Methods. A model was developed, comparing a cohort of all 12‐year‐old girls alive in year 2006, with or without vaccination. The model was based on the epidemiology of cervical cancer in Iceland and its premalignant stages as well as the costs involved in the treatment of each stage, assuming that the vaccines only prevent infections caused by HPV 16/18 at an efficacy of 95% and participation rate of 90%, no catch‐up vaccination, no vaccination of boys and no booster dose needed. All costs were calculated on the basis of the price level of mid‐year 2006 with a 3% discount rate. Incremental cost‐effectiveness ratio calculations were performed and sensitivity analysis was carried out on factors most relevant for cost‐effectiveness. Results. Vaccination costs in excess of savings would be about €313.000/year. Vaccination would reduce the number of women diagnosed with cervical cancer by almost 9, prevent the death of 1.7 women and result in 16.9 quality‐adjusted life years gained annually. The incremental cost‐effectiveness ratio was calculated to be about €18.500/quality‐adjusted life year saved. Conclusion. HPV vaccination seems to be cost‐effective in Iceland, but this was sensitive to various parameters in the model, mainly the discount rate, the price of the vaccines and the need for a booster dose. Article in Journal/Newspaper Iceland Wiley Online Library (via Crossref) Acta Obstetricia et Gynecologica Scandinavica 88 12 1411 1416 |
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Wiley Online Library (via Crossref) |
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English |
topic |
Obstetrics and Gynecology General Medicine |
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Obstetrics and Gynecology General Medicine ODDSSON, KRISTJAN JOHANNSSON, JAKOB ASGEIRSDOTTIR, TINNA LAUFEY GUDNASON, THOROLFUR Cost‐effectiveness of human papilloma virus vaccination in Iceland |
topic_facet |
Obstetrics and Gynecology General Medicine |
description |
Abstract Objective. To evaluate the likely cost‐effectiveness of introducing routine HPV vaccination in Iceland. Design. Prospective cost‐effectiveness analysis of human papilloma virus (HPV) vaccination. Setting and sample. Population of 12‐year‐old girls in the Icelandic population. Methods. A model was developed, comparing a cohort of all 12‐year‐old girls alive in year 2006, with or without vaccination. The model was based on the epidemiology of cervical cancer in Iceland and its premalignant stages as well as the costs involved in the treatment of each stage, assuming that the vaccines only prevent infections caused by HPV 16/18 at an efficacy of 95% and participation rate of 90%, no catch‐up vaccination, no vaccination of boys and no booster dose needed. All costs were calculated on the basis of the price level of mid‐year 2006 with a 3% discount rate. Incremental cost‐effectiveness ratio calculations were performed and sensitivity analysis was carried out on factors most relevant for cost‐effectiveness. Results. Vaccination costs in excess of savings would be about €313.000/year. Vaccination would reduce the number of women diagnosed with cervical cancer by almost 9, prevent the death of 1.7 women and result in 16.9 quality‐adjusted life years gained annually. The incremental cost‐effectiveness ratio was calculated to be about €18.500/quality‐adjusted life year saved. Conclusion. HPV vaccination seems to be cost‐effective in Iceland, but this was sensitive to various parameters in the model, mainly the discount rate, the price of the vaccines and the need for a booster dose. |
format |
Article in Journal/Newspaper |
author |
ODDSSON, KRISTJAN JOHANNSSON, JAKOB ASGEIRSDOTTIR, TINNA LAUFEY GUDNASON, THOROLFUR |
author_facet |
ODDSSON, KRISTJAN JOHANNSSON, JAKOB ASGEIRSDOTTIR, TINNA LAUFEY GUDNASON, THOROLFUR |
author_sort |
ODDSSON, KRISTJAN |
title |
Cost‐effectiveness of human papilloma virus vaccination in Iceland |
title_short |
Cost‐effectiveness of human papilloma virus vaccination in Iceland |
title_full |
Cost‐effectiveness of human papilloma virus vaccination in Iceland |
title_fullStr |
Cost‐effectiveness of human papilloma virus vaccination in Iceland |
title_full_unstemmed |
Cost‐effectiveness of human papilloma virus vaccination in Iceland |
title_sort |
cost‐effectiveness of human papilloma virus vaccination in iceland |
publisher |
Wiley |
publishDate |
2009 |
url |
http://dx.doi.org/10.3109/00016340903322750 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.3109%2F00016340903322750 https://obgyn.onlinelibrary.wiley.com/doi/pdf/10.3109/00016340903322750 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Acta Obstetricia et Gynecologica Scandinavica volume 88, issue 12, page 1411-1416 ISSN 0001-6349 1600-0412 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.3109/00016340903322750 |
container_title |
Acta Obstetricia et Gynecologica Scandinavica |
container_volume |
88 |
container_issue |
12 |
container_start_page |
1411 |
op_container_end_page |
1416 |
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1784273160948940800 |