Bone‐related effects of contaminants in seals may be associated with vitamin D and thyroid hormones
Abstract The high levels of polychlorinated biphenyls (PCBs) and DDT in gray seal ( Halichoerus grypus ) and ringed seal ( Phoca hispida botnica ) in the Baltic Sea have been associated with pathological disruptions, including bone lesions and reproductive failures. The underlying environmental and...
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crwiley:10.1897/07-139.1 2024-09-15T18:30:20+00:00 Bone‐related effects of contaminants in seals may be associated with vitamin D and thyroid hormones Routti, Heli Nyman, Madeleine Jenssen, Bjørn Munro Bäckman, Christina Koistinen, Jaana Gabrielsen, Geir Wing 2008 http://dx.doi.org/10.1897/07-139.1 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1897%2F07-139.1 https://setac.onlinelibrary.wiley.com/doi/pdf/10.1897/07-139.1 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Environmental Toxicology and Chemistry volume 27, issue 4, page 873-880 ISSN 0730-7268 1552-8618 journal-article 2008 crwiley https://doi.org/10.1897/07-139.1 2024-08-13T04:16:35Z Abstract The high levels of polychlorinated biphenyls (PCBs) and DDT in gray seal ( Halichoerus grypus ) and ringed seal ( Phoca hispida botnica ) in the Baltic Sea have been associated with pathological disruptions, including bone lesions and reproductive failures. The underlying environmental and toxicological mechanisms leading to these pathological changes are not yet fully understood. The present study investigated the relationship between the individual contaminant load and bone‐ and thyroid‐related effects in adult gray seals ( n = 30) and ringed seals ( n = 46) in the highly contaminated Baltic Sea and in reference areas (Sable Island, Canada, and Svalbard, Norway). In the gray seals, multivariate and correlation analyses revealed a clear relationship between circulating 1,25‐dihydroxyvitamin D 3 (1,25(OH) 2 D), calcium, phosphate, and thyroid hormone (TH) levels and hepatic PCB and DDT load, which suggests contaminant‐mediated disruption of the bone and thyroid homeostasis. Contaminants may depress 1,25(OH) 2 D levels or lead to hyperthyroidism, which may cause bone resorption. In the ringed seals, associations between circulating 1,25(OH) 2 D, THs, and hepatic contaminants were less prominent. These results suggest that bone lesions observed in the Baltic gray seals may be associated with contaminant‐mediated vitamin D and thyroid disruption. Article in Journal/Newspaper Phoca hispida ringed seal Svalbard Wiley Online Library Environmental Toxicology and Chemistry 27 4 873 880 |
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Wiley Online Library |
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English |
description |
Abstract The high levels of polychlorinated biphenyls (PCBs) and DDT in gray seal ( Halichoerus grypus ) and ringed seal ( Phoca hispida botnica ) in the Baltic Sea have been associated with pathological disruptions, including bone lesions and reproductive failures. The underlying environmental and toxicological mechanisms leading to these pathological changes are not yet fully understood. The present study investigated the relationship between the individual contaminant load and bone‐ and thyroid‐related effects in adult gray seals ( n = 30) and ringed seals ( n = 46) in the highly contaminated Baltic Sea and in reference areas (Sable Island, Canada, and Svalbard, Norway). In the gray seals, multivariate and correlation analyses revealed a clear relationship between circulating 1,25‐dihydroxyvitamin D 3 (1,25(OH) 2 D), calcium, phosphate, and thyroid hormone (TH) levels and hepatic PCB and DDT load, which suggests contaminant‐mediated disruption of the bone and thyroid homeostasis. Contaminants may depress 1,25(OH) 2 D levels or lead to hyperthyroidism, which may cause bone resorption. In the ringed seals, associations between circulating 1,25(OH) 2 D, THs, and hepatic contaminants were less prominent. These results suggest that bone lesions observed in the Baltic gray seals may be associated with contaminant‐mediated vitamin D and thyroid disruption. |
format |
Article in Journal/Newspaper |
author |
Routti, Heli Nyman, Madeleine Jenssen, Bjørn Munro Bäckman, Christina Koistinen, Jaana Gabrielsen, Geir Wing |
spellingShingle |
Routti, Heli Nyman, Madeleine Jenssen, Bjørn Munro Bäckman, Christina Koistinen, Jaana Gabrielsen, Geir Wing Bone‐related effects of contaminants in seals may be associated with vitamin D and thyroid hormones |
author_facet |
Routti, Heli Nyman, Madeleine Jenssen, Bjørn Munro Bäckman, Christina Koistinen, Jaana Gabrielsen, Geir Wing |
author_sort |
Routti, Heli |
title |
Bone‐related effects of contaminants in seals may be associated with vitamin D and thyroid hormones |
title_short |
Bone‐related effects of contaminants in seals may be associated with vitamin D and thyroid hormones |
title_full |
Bone‐related effects of contaminants in seals may be associated with vitamin D and thyroid hormones |
title_fullStr |
Bone‐related effects of contaminants in seals may be associated with vitamin D and thyroid hormones |
title_full_unstemmed |
Bone‐related effects of contaminants in seals may be associated with vitamin D and thyroid hormones |
title_sort |
bone‐related effects of contaminants in seals may be associated with vitamin d and thyroid hormones |
publisher |
Wiley |
publishDate |
2008 |
url |
http://dx.doi.org/10.1897/07-139.1 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1897%2F07-139.1 https://setac.onlinelibrary.wiley.com/doi/pdf/10.1897/07-139.1 |
genre |
Phoca hispida ringed seal Svalbard |
genre_facet |
Phoca hispida ringed seal Svalbard |
op_source |
Environmental Toxicology and Chemistry volume 27, issue 4, page 873-880 ISSN 0730-7268 1552-8618 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1897/07-139.1 |
container_title |
Environmental Toxicology and Chemistry |
container_volume |
27 |
container_issue |
4 |
container_start_page |
873 |
op_container_end_page |
880 |
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1810471806103977984 |