Association between lymphocyte proliferation and polychlorinated biphenyls in free‐ranging harbor seal ( Phoca vitulina ) pups from British Columbia, Canada
Abstract Recent pinniped die‐offs have led to the speculation that persistent organic pollutants (POPs) are immunomodulatory, making individuals more susceptible to viral infections. Eighteen healthy harbor seal ( Phoca vitulina ) pups (aged 3–4 weeks) were live‐captured from southern British Columb...
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crwiley:10.1897/04-206r.1 2023-12-03T10:23:45+01:00 Association between lymphocyte proliferation and polychlorinated biphenyls in free‐ranging harbor seal ( Phoca vitulina ) pups from British Columbia, Canada Levin, Milton De Guise, Sylvain Ross, Peter S. 2005 http://dx.doi.org/10.1897/04-206r.1 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1897%2F04-206R.1 https://setac.onlinelibrary.wiley.com/doi/pdf/10.1897/04-206R.1 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Environmental Toxicology and Chemistry volume 24, issue 5, page 1247-1252 ISSN 0730-7268 1552-8618 Health, Toxicology and Mutagenesis Environmental Chemistry journal-article 2005 crwiley https://doi.org/10.1897/04-206r.1 2023-11-09T13:28:37Z Abstract Recent pinniped die‐offs have led to the speculation that persistent organic pollutants (POPs) are immunomodulatory, making individuals more susceptible to viral infections. Eighteen healthy harbor seal ( Phoca vitulina ) pups (aged 3–4 weeks) were live‐captured from southern British Columbia, Canada, and maintained temporarily in captivity for an immunotoxicological assessment. The relationships between mitogen‐induced peripheral blood lymphocyte proliferation and blubber concentrations of three major immunotoxic POP classes (the polychlorinated biphenyls [PCBs], polychlorinated dibenzo‐ p ‐dioxins [PCDDs], and the polychlorinated dibenzofurans [PCDFs]) were evaluated. A significant body weight‐independent positive correlation was observed between both T‐cell mitogen (phytohemagglutinin [PHA])‐ and B‐cell mitogen (lipopolysaccharide [LPS])‐induced lymphocyte proliferation and the blubber concentrations of total PCB. Best subset regression analysis revealed that total PCBs, and not total PCDD or total PCDF, explained 24 and 29% of the changes in both T‐cell mitogen‐and B‐cell mitogen‐induced lymphocyte proliferation, respectively. Further regression analysis performed on the PCB classes measured in this study showed that di ‐ ortho PCBs accounted for 25 and 30% of the changes in both T‐cell and B‐cell lymphocyte proliferation, respectively. Results suggest that POPs, and PCBs in particular, are associated with changes in lymphocyte proliferation, something that could result in increased susceptibility to infections in harbor seal pups. Further research is needed to evaluate the relative roles of natural and contaminant‐related influences on the immune system of marine mammals. Article in Journal/Newspaper harbor seal Phoca vitulina Wiley Online Library (via Crossref) British Columbia ENVELOPE(-125.003,-125.003,54.000,54.000) Canada Environmental Toxicology and Chemistry 24 5 1247 |
institution |
Open Polar |
collection |
Wiley Online Library (via Crossref) |
op_collection_id |
crwiley |
language |
English |
topic |
Health, Toxicology and Mutagenesis Environmental Chemistry |
spellingShingle |
Health, Toxicology and Mutagenesis Environmental Chemistry Levin, Milton De Guise, Sylvain Ross, Peter S. Association between lymphocyte proliferation and polychlorinated biphenyls in free‐ranging harbor seal ( Phoca vitulina ) pups from British Columbia, Canada |
topic_facet |
Health, Toxicology and Mutagenesis Environmental Chemistry |
description |
Abstract Recent pinniped die‐offs have led to the speculation that persistent organic pollutants (POPs) are immunomodulatory, making individuals more susceptible to viral infections. Eighteen healthy harbor seal ( Phoca vitulina ) pups (aged 3–4 weeks) were live‐captured from southern British Columbia, Canada, and maintained temporarily in captivity for an immunotoxicological assessment. The relationships between mitogen‐induced peripheral blood lymphocyte proliferation and blubber concentrations of three major immunotoxic POP classes (the polychlorinated biphenyls [PCBs], polychlorinated dibenzo‐ p ‐dioxins [PCDDs], and the polychlorinated dibenzofurans [PCDFs]) were evaluated. A significant body weight‐independent positive correlation was observed between both T‐cell mitogen (phytohemagglutinin [PHA])‐ and B‐cell mitogen (lipopolysaccharide [LPS])‐induced lymphocyte proliferation and the blubber concentrations of total PCB. Best subset regression analysis revealed that total PCBs, and not total PCDD or total PCDF, explained 24 and 29% of the changes in both T‐cell mitogen‐and B‐cell mitogen‐induced lymphocyte proliferation, respectively. Further regression analysis performed on the PCB classes measured in this study showed that di ‐ ortho PCBs accounted for 25 and 30% of the changes in both T‐cell and B‐cell lymphocyte proliferation, respectively. Results suggest that POPs, and PCBs in particular, are associated with changes in lymphocyte proliferation, something that could result in increased susceptibility to infections in harbor seal pups. Further research is needed to evaluate the relative roles of natural and contaminant‐related influences on the immune system of marine mammals. |
format |
Article in Journal/Newspaper |
author |
Levin, Milton De Guise, Sylvain Ross, Peter S. |
author_facet |
Levin, Milton De Guise, Sylvain Ross, Peter S. |
author_sort |
Levin, Milton |
title |
Association between lymphocyte proliferation and polychlorinated biphenyls in free‐ranging harbor seal ( Phoca vitulina ) pups from British Columbia, Canada |
title_short |
Association between lymphocyte proliferation and polychlorinated biphenyls in free‐ranging harbor seal ( Phoca vitulina ) pups from British Columbia, Canada |
title_full |
Association between lymphocyte proliferation and polychlorinated biphenyls in free‐ranging harbor seal ( Phoca vitulina ) pups from British Columbia, Canada |
title_fullStr |
Association between lymphocyte proliferation and polychlorinated biphenyls in free‐ranging harbor seal ( Phoca vitulina ) pups from British Columbia, Canada |
title_full_unstemmed |
Association between lymphocyte proliferation and polychlorinated biphenyls in free‐ranging harbor seal ( Phoca vitulina ) pups from British Columbia, Canada |
title_sort |
association between lymphocyte proliferation and polychlorinated biphenyls in free‐ranging harbor seal ( phoca vitulina ) pups from british columbia, canada |
publisher |
Wiley |
publishDate |
2005 |
url |
http://dx.doi.org/10.1897/04-206r.1 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1897%2F04-206R.1 https://setac.onlinelibrary.wiley.com/doi/pdf/10.1897/04-206R.1 |
long_lat |
ENVELOPE(-125.003,-125.003,54.000,54.000) |
geographic |
British Columbia Canada |
geographic_facet |
British Columbia Canada |
genre |
harbor seal Phoca vitulina |
genre_facet |
harbor seal Phoca vitulina |
op_source |
Environmental Toxicology and Chemistry volume 24, issue 5, page 1247-1252 ISSN 0730-7268 1552-8618 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1897/04-206r.1 |
container_title |
Environmental Toxicology and Chemistry |
container_volume |
24 |
container_issue |
5 |
container_start_page |
1247 |
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1784271992685330432 |