Metabolic Differences between Dogs of Different Body Sizes
Introduction. The domesticated dog, Canis lupus familiaris , has been selectively bred to produce extreme diversity in phenotype and genotype. Dogs have an immense diversity in weight and height. Specific differences in metabolism have not been characterized in small dogs as compared to larger dogs....
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crwiley:10.1155/2017/4535710 2024-09-15T18:01:16+00:00 Metabolic Differences between Dogs of Different Body Sizes Middleton, Rondo P. Lacroix, Sebastien Scott-Boyer, Marie-Pier Dordevic, Nikola Kennedy, Adam D. Slusky, Amanda R. Carayol, Jerome Petzinger-Germain, Christina Beloshapka, Alison Kaput, Jim Nestlé Purina 2017 http://dx.doi.org/10.1155/2017/4535710 http://downloads.hindawi.com/journals/jnme/2017/4535710.pdf http://downloads.hindawi.com/journals/jnme/2017/4535710.xml en eng Wiley http://creativecommons.org/licenses/by/4.0/ Journal of Nutrition and Metabolism volume 2017, page 1-11 ISSN 2090-0724 2090-0732 journal-article 2017 crwiley https://doi.org/10.1155/2017/4535710 2024-08-06T04:16:44Z Introduction. The domesticated dog, Canis lupus familiaris , has been selectively bred to produce extreme diversity in phenotype and genotype. Dogs have an immense diversity in weight and height. Specific differences in metabolism have not been characterized in small dogs as compared to larger dogs. Objectives. This study aims to identify metabolic, clinical, and microbiota differences between small and larger dogs. Methods. Gas chromatography/mass spectrometry, liquid chromatography/tandem mass spectrometry, clinical chemistry analysis, dual-energy X-ray absorptiometry, and 16S pyrosequencing were used to characterize blood metabolic, clinical, and fecal microbiome systems, respectively. Eighty-three canines from seven different breeds, fed the same kibble diet for 5 weeks, were used in the study. Results. 449 metabolites, 16 clinical parameters, and 6 bacteria (at the genus level) were significantly different between small and larger dogs. Hierarchical clustering of the metabolites yielded 8 modules associated with small dog size. Conclusion. Small dogs had a lower antioxidant status and differences in circulating amino acids. Some of the amino acid differences could be attributed to differences in microflora. Additionally, analysis of small dog metabolites and clinical parameters reflected a network which strongly associates with kidney function. Article in Journal/Newspaper Canis lupus Wiley Online Library Journal of Nutrition and Metabolism 2017 1 11 |
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Wiley Online Library |
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English |
description |
Introduction. The domesticated dog, Canis lupus familiaris , has been selectively bred to produce extreme diversity in phenotype and genotype. Dogs have an immense diversity in weight and height. Specific differences in metabolism have not been characterized in small dogs as compared to larger dogs. Objectives. This study aims to identify metabolic, clinical, and microbiota differences between small and larger dogs. Methods. Gas chromatography/mass spectrometry, liquid chromatography/tandem mass spectrometry, clinical chemistry analysis, dual-energy X-ray absorptiometry, and 16S pyrosequencing were used to characterize blood metabolic, clinical, and fecal microbiome systems, respectively. Eighty-three canines from seven different breeds, fed the same kibble diet for 5 weeks, were used in the study. Results. 449 metabolites, 16 clinical parameters, and 6 bacteria (at the genus level) were significantly different between small and larger dogs. Hierarchical clustering of the metabolites yielded 8 modules associated with small dog size. Conclusion. Small dogs had a lower antioxidant status and differences in circulating amino acids. Some of the amino acid differences could be attributed to differences in microflora. Additionally, analysis of small dog metabolites and clinical parameters reflected a network which strongly associates with kidney function. |
author2 |
Nestlé Purina |
format |
Article in Journal/Newspaper |
author |
Middleton, Rondo P. Lacroix, Sebastien Scott-Boyer, Marie-Pier Dordevic, Nikola Kennedy, Adam D. Slusky, Amanda R. Carayol, Jerome Petzinger-Germain, Christina Beloshapka, Alison Kaput, Jim |
spellingShingle |
Middleton, Rondo P. Lacroix, Sebastien Scott-Boyer, Marie-Pier Dordevic, Nikola Kennedy, Adam D. Slusky, Amanda R. Carayol, Jerome Petzinger-Germain, Christina Beloshapka, Alison Kaput, Jim Metabolic Differences between Dogs of Different Body Sizes |
author_facet |
Middleton, Rondo P. Lacroix, Sebastien Scott-Boyer, Marie-Pier Dordevic, Nikola Kennedy, Adam D. Slusky, Amanda R. Carayol, Jerome Petzinger-Germain, Christina Beloshapka, Alison Kaput, Jim |
author_sort |
Middleton, Rondo P. |
title |
Metabolic Differences between Dogs of Different Body Sizes |
title_short |
Metabolic Differences between Dogs of Different Body Sizes |
title_full |
Metabolic Differences between Dogs of Different Body Sizes |
title_fullStr |
Metabolic Differences between Dogs of Different Body Sizes |
title_full_unstemmed |
Metabolic Differences between Dogs of Different Body Sizes |
title_sort |
metabolic differences between dogs of different body sizes |
publisher |
Wiley |
publishDate |
2017 |
url |
http://dx.doi.org/10.1155/2017/4535710 http://downloads.hindawi.com/journals/jnme/2017/4535710.pdf http://downloads.hindawi.com/journals/jnme/2017/4535710.xml |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_source |
Journal of Nutrition and Metabolism volume 2017, page 1-11 ISSN 2090-0724 2090-0732 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1155/2017/4535710 |
container_title |
Journal of Nutrition and Metabolism |
container_volume |
2017 |
container_start_page |
1 |
op_container_end_page |
11 |
_version_ |
1810438437407293440 |