Segmentation of pulmonary nodules in three‐dimensional CT images by use of a spiral‐scanning technique

• Published in: Medical Physics
• Main Authors: Wang, Jiahui, Engelmann, Roger, Li, Qiang
• Other Authors: U.S. Public Health Service
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2007
• Subjects: North Pole; South Pole; South pole
• Online Access: http://dx.doi.org/10.1118/1.2799885; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1118%2F1.2799885; https://aapm.onlinelibrary.wiley.com/doi/pdf/10.1118/1.2799885

Accurate segmentation of pulmonary nodules in computed tomography (CT) is an important and difficult task for computer‐aided diagnosis of lung cancer. Therefore, the authors developed a novel automated method for accurate segmentation of nodules in three‐dimensional (3D) CT. First, a volume of interest (VOI) was determined at the location of a nodule. To simplify nodule segmentation, the 3D VOI was transformed into a two‐dimensional (2D) image by use of a key “spiral‐scanning” technique, in which a number of radial lines originating from the center of the VOI spirally scanned the VOI from the “north pole” to the “south pole.” The voxels scanned by the radial lines provided a transformed 2D image. Because the surface of a nodule in the 3D image became a curve in the transformed 2D image, the spiral‐scanning technique considerably simplified the segmentation method and enabled reliable segmentation results to be obtained. A dynamic programming technique was employed to delineate the “optimal” outline of a nodule in the 2D image, which corresponded to the surface of the nodule in the 3D image. The optimal outline was then transformed back into 3D image space to provide the surface of the nodule. An overlap between nodule regions provided by computer and by the radiologists was employed as a performance metric for evaluating the segmentation method. The database included two Lung Imaging Database Consortium (LIDC) data sets that contained 23 and 86 CT scans, respectively, with 23 and 73 nodules that were 3 mm or larger in diameter. For the two data sets, six and four radiologists manually delineated the outlines of the nodules as reference standards in a performance evaluation for nodule segmentation. The segmentation method was trained on the first and was tested on the second LIDC data sets. The mean overlap values were and for the nodules in the first and second LIDC data sets, respectively, which represented a higher performance level than those of two existing segmentation methods that were also evaluated by ...