Hepatitis E virus in Common voles ( Microtus arvalis) from an urban environment, Hungary: Discovery of a Cricetidae‐specific genotype of Orthohepevirus C
Abstract Hepatitis E virus is a major causative agent of acute hepatitis worldwide. Despite its zoonotic potential, there is limited information about the natural chain of hepevirus infection in wildlife, and the potential reservoir species. In this study, we performed a HEV survey by heminested RT‐...
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Online Access: | http://dx.doi.org/10.1111/zph.12543 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fzph.12543 https://onlinelibrary.wiley.com/doi/pdf/10.1111/zph.12543 |
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crwiley:10.1111/zph.12543 2024-09-15T18:18:45+00:00 Hepatitis E virus in Common voles ( Microtus arvalis) from an urban environment, Hungary: Discovery of a Cricetidae‐specific genotype of Orthohepevirus C Kurucz, Kornélia Hederics, Dávid Bali, Dominika Kemenesi, Gábor Horváth, Győző Jakab, Ferenc European Social Fund Pécsi Tudományegyetem 2018 http://dx.doi.org/10.1111/zph.12543 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fzph.12543 https://onlinelibrary.wiley.com/doi/pdf/10.1111/zph.12543 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Zoonoses and Public Health volume 66, issue 2, page 259-263 ISSN 1863-1959 1863-2378 journal-article 2018 crwiley https://doi.org/10.1111/zph.12543 2024-06-27T04:22:28Z Abstract Hepatitis E virus is a major causative agent of acute hepatitis worldwide. Despite its zoonotic potential, there is limited information about the natural chain of hepevirus infection in wildlife, and the potential reservoir species. In this study, we performed a HEV survey by heminested RT‐PCR on rodent samples from an urban environment (in the city of Pécs, Hungary) and investigated the prevalence of the virus among these native rodent species ( Apodemus agrarius , Apodemus flavicollis , Apodemus sylvaticus , Microtus arvalis and Myodes glareolus ). HEV was detected exclusively in Common voles ( M. arvalis ), in 10.2% of screened voles, and 3.2% of all investigated samples from all species. Based on the phylogenetic analysis, our strain showed the closest homology with European Orthohepevirus C strains detected previously in faecal samples of birds of prey and Red fox, supporting the possibility of the dietary origin of these strains. In addition, our samples showed close phylogenetic relation with a South American strain detected in Necromys lasiurus (Cricetidae), but separated clearly from other Muridae‐associated strains, suggesting the presence of a Cricetidae‐specific genotype in Europe and South‐America. Based on these results, we hypothesize the reservoir role of M. arvalis rodents for the European Cricetidae‐specific Orthohepevirus C genotype. Article in Journal/Newspaper Microtus arvalis Wiley Online Library Zoonoses and Public Health 66 2 259 263 |
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Wiley Online Library |
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English |
description |
Abstract Hepatitis E virus is a major causative agent of acute hepatitis worldwide. Despite its zoonotic potential, there is limited information about the natural chain of hepevirus infection in wildlife, and the potential reservoir species. In this study, we performed a HEV survey by heminested RT‐PCR on rodent samples from an urban environment (in the city of Pécs, Hungary) and investigated the prevalence of the virus among these native rodent species ( Apodemus agrarius , Apodemus flavicollis , Apodemus sylvaticus , Microtus arvalis and Myodes glareolus ). HEV was detected exclusively in Common voles ( M. arvalis ), in 10.2% of screened voles, and 3.2% of all investigated samples from all species. Based on the phylogenetic analysis, our strain showed the closest homology with European Orthohepevirus C strains detected previously in faecal samples of birds of prey and Red fox, supporting the possibility of the dietary origin of these strains. In addition, our samples showed close phylogenetic relation with a South American strain detected in Necromys lasiurus (Cricetidae), but separated clearly from other Muridae‐associated strains, suggesting the presence of a Cricetidae‐specific genotype in Europe and South‐America. Based on these results, we hypothesize the reservoir role of M. arvalis rodents for the European Cricetidae‐specific Orthohepevirus C genotype. |
author2 |
European Social Fund Pécsi Tudományegyetem |
format |
Article in Journal/Newspaper |
author |
Kurucz, Kornélia Hederics, Dávid Bali, Dominika Kemenesi, Gábor Horváth, Győző Jakab, Ferenc |
spellingShingle |
Kurucz, Kornélia Hederics, Dávid Bali, Dominika Kemenesi, Gábor Horváth, Győző Jakab, Ferenc Hepatitis E virus in Common voles ( Microtus arvalis) from an urban environment, Hungary: Discovery of a Cricetidae‐specific genotype of Orthohepevirus C |
author_facet |
Kurucz, Kornélia Hederics, Dávid Bali, Dominika Kemenesi, Gábor Horváth, Győző Jakab, Ferenc |
author_sort |
Kurucz, Kornélia |
title |
Hepatitis E virus in Common voles ( Microtus arvalis) from an urban environment, Hungary: Discovery of a Cricetidae‐specific genotype of Orthohepevirus C |
title_short |
Hepatitis E virus in Common voles ( Microtus arvalis) from an urban environment, Hungary: Discovery of a Cricetidae‐specific genotype of Orthohepevirus C |
title_full |
Hepatitis E virus in Common voles ( Microtus arvalis) from an urban environment, Hungary: Discovery of a Cricetidae‐specific genotype of Orthohepevirus C |
title_fullStr |
Hepatitis E virus in Common voles ( Microtus arvalis) from an urban environment, Hungary: Discovery of a Cricetidae‐specific genotype of Orthohepevirus C |
title_full_unstemmed |
Hepatitis E virus in Common voles ( Microtus arvalis) from an urban environment, Hungary: Discovery of a Cricetidae‐specific genotype of Orthohepevirus C |
title_sort |
hepatitis e virus in common voles ( microtus arvalis) from an urban environment, hungary: discovery of a cricetidae‐specific genotype of orthohepevirus c |
publisher |
Wiley |
publishDate |
2018 |
url |
http://dx.doi.org/10.1111/zph.12543 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fzph.12543 https://onlinelibrary.wiley.com/doi/pdf/10.1111/zph.12543 |
genre |
Microtus arvalis |
genre_facet |
Microtus arvalis |
op_source |
Zoonoses and Public Health volume 66, issue 2, page 259-263 ISSN 1863-1959 1863-2378 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/zph.12543 |
container_title |
Zoonoses and Public Health |
container_volume |
66 |
container_issue |
2 |
container_start_page |
259 |
op_container_end_page |
263 |
_version_ |
1810456824934039552 |