Altered plasma cytokines in dogs with atopic dermatitis
Background Canine ( Canis lupus familiaris ) atopic dermatitis (AD) shares similar clinical signs to human AD. The abnormal immune response of AD is orchestrated by T lymphocytes, and may include variable involvement of cytokines, regulatory T (Treg) cells, eosinophils, mast cells and other immune c...
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crwiley:10.1111/vde.13044 2024-06-23T07:51:59+00:00 Altered plasma cytokines in dogs with atopic dermatitis Mazrier, Hamutal Vogelnest, Linda J. Taylor, Rosanne M. Williamson, Peter 2021 http://dx.doi.org/10.1111/vde.13044 https://onlinelibrary.wiley.com/doi/pdf/10.1111/vde.13044 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/vde.13044 en eng Wiley http://creativecommons.org/licenses/by-nc-nd/4.0/ Veterinary Dermatology volume 33, issue 2, page 131 ISSN 0959-4493 1365-3164 journal-article 2021 crwiley https://doi.org/10.1111/vde.13044 2024-05-31T08:11:20Z Background Canine ( Canis lupus familiaris ) atopic dermatitis (AD) shares similar clinical signs to human AD. The abnormal immune response of AD is orchestrated by T lymphocytes, and may include variable involvement of cytokines, regulatory T (Treg) cells, eosinophils, mast cells and other immune components. Helper T (Th)2 cytokines often predominate initially, followed by Th1 cytokines in more chronic phases. Hypothesis/Objectives Pro‐inflammatory and Treg cytokines have been shown to play a role in human AD, yet their importance is not clear in canine AD. Hence, this study aimed to measure the concentrations of cytokines/chemokines not traditionally associated with Th1/Th2 response. Animals Canine AD patients (n = 27), compared to control dogs (n = 11). Methods and materials A total of 19 plasma cytokines were assayed using canine specific multiplex immuno‐assays. Results The plasma concentrations of CXC Motif Chemokine Ligand 8 (CXCL8), interleukin (IL)‐7 and IL‐15 cytokines were elevated in canine AD patients, compared to control dogs. In addition, stem‐cell factor (SCF) concentrations were reduced in the plasma of canine AD patients compared to control dogs. Distinct cytokine profiles were found in dogs belonging to the Staffordshire breeds, a group with increased risk of AD. In particular, granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) had significantly elevated concentrations. Conclusions and clinical relevance Some of the plasma cytokine alterations in canine AD described here, particularly of IL‐7, have not been reported previously. Monitoring these distinctive cytokine alterations could be useful for diagnosis and monitoring of canine AD in dogs. Article in Journal/Newspaper Canis lupus Wiley Online Library Veterinary Dermatology 33 2 131 |
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Background Canine ( Canis lupus familiaris ) atopic dermatitis (AD) shares similar clinical signs to human AD. The abnormal immune response of AD is orchestrated by T lymphocytes, and may include variable involvement of cytokines, regulatory T (Treg) cells, eosinophils, mast cells and other immune components. Helper T (Th)2 cytokines often predominate initially, followed by Th1 cytokines in more chronic phases. Hypothesis/Objectives Pro‐inflammatory and Treg cytokines have been shown to play a role in human AD, yet their importance is not clear in canine AD. Hence, this study aimed to measure the concentrations of cytokines/chemokines not traditionally associated with Th1/Th2 response. Animals Canine AD patients (n = 27), compared to control dogs (n = 11). Methods and materials A total of 19 plasma cytokines were assayed using canine specific multiplex immuno‐assays. Results The plasma concentrations of CXC Motif Chemokine Ligand 8 (CXCL8), interleukin (IL)‐7 and IL‐15 cytokines were elevated in canine AD patients, compared to control dogs. In addition, stem‐cell factor (SCF) concentrations were reduced in the plasma of canine AD patients compared to control dogs. Distinct cytokine profiles were found in dogs belonging to the Staffordshire breeds, a group with increased risk of AD. In particular, granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) had significantly elevated concentrations. Conclusions and clinical relevance Some of the plasma cytokine alterations in canine AD described here, particularly of IL‐7, have not been reported previously. Monitoring these distinctive cytokine alterations could be useful for diagnosis and monitoring of canine AD in dogs. |
format |
Article in Journal/Newspaper |
author |
Mazrier, Hamutal Vogelnest, Linda J. Taylor, Rosanne M. Williamson, Peter |
spellingShingle |
Mazrier, Hamutal Vogelnest, Linda J. Taylor, Rosanne M. Williamson, Peter Altered plasma cytokines in dogs with atopic dermatitis |
author_facet |
Mazrier, Hamutal Vogelnest, Linda J. Taylor, Rosanne M. Williamson, Peter |
author_sort |
Mazrier, Hamutal |
title |
Altered plasma cytokines in dogs with atopic dermatitis |
title_short |
Altered plasma cytokines in dogs with atopic dermatitis |
title_full |
Altered plasma cytokines in dogs with atopic dermatitis |
title_fullStr |
Altered plasma cytokines in dogs with atopic dermatitis |
title_full_unstemmed |
Altered plasma cytokines in dogs with atopic dermatitis |
title_sort |
altered plasma cytokines in dogs with atopic dermatitis |
publisher |
Wiley |
publishDate |
2021 |
url |
http://dx.doi.org/10.1111/vde.13044 https://onlinelibrary.wiley.com/doi/pdf/10.1111/vde.13044 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/vde.13044 |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_source |
Veterinary Dermatology volume 33, issue 2, page 131 ISSN 0959-4493 1365-3164 |
op_rights |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
op_doi |
https://doi.org/10.1111/vde.13044 |
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Veterinary Dermatology |
container_volume |
33 |
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2 |
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131 |
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1802643163943272448 |