Environmental pollutants in blood donors: The multicentre Norwegian donor study
Abstract Objectives The aim of this study was to measure blood concentrations of environmental pollutants in Norwegian donors and evaluate the risk of pollutant exposure through blood transfusions. Background Transfused blood may be a potential source of exposure to heavy metals and organic pollutan...
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Online Access: | http://dx.doi.org/10.1111/tme.12662 https://onlinelibrary.wiley.com/doi/pdf/10.1111/tme.12662 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/tme.12662 |
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crwiley:10.1111/tme.12662 2024-09-30T14:38:06+00:00 Environmental pollutants in blood donors: The multicentre Norwegian donor study Averina, Maria Hervig, Tor Huber, Sandra Kjær, Mette Kristoffersen, Einar K. Bolann, Bjørn 2020 http://dx.doi.org/10.1111/tme.12662 https://onlinelibrary.wiley.com/doi/pdf/10.1111/tme.12662 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/tme.12662 en eng Wiley http://creativecommons.org/licenses/by-nc/4.0/ Transfusion Medicine volume 30, issue 3, page 201-209 ISSN 0958-7578 1365-3148 journal-article 2020 crwiley https://doi.org/10.1111/tme.12662 2024-09-03T04:21:48Z Abstract Objectives The aim of this study was to measure blood concentrations of environmental pollutants in Norwegian donors and evaluate the risk of pollutant exposure through blood transfusions. Background Transfused blood may be a potential source of exposure to heavy metals and organic pollutants and presents a risk to vulnerable patient groups such as premature infants. Methods/Materials Donors were randomly recruited from three Norwegian blood banks: in Bergen, Tromsø and Kirkenes. Selected heavy metals were measured in whole blood using inductively coupled plasma mass spectrometry (ICP‐MS), and perfluoroalkyl substances (PFAS) were measured in serum by ultrahigh‐pressure liquid chromatography coupled with a triple‐quadrupole mass spectrometer (UHPLC‐MS/MS). Results Almost 18% of blood donors had lead concentrations over the limit suggested for transfusions in premature infants (0.09 μmol/L). About 11% of all donors had mercury concentrations over the suggested limit of 23.7 nmol/L. Cadmium was higher than the limit, 16 nmol/L, in 4% of donors. Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) concentrations were over the suggested limit of 0.91 ng/mL in 68% and 100% of the donors, respectively. PFAS concentrations and heavy metal concentrations increased with donor's age. Conclusion A considerable percentage of donors had lead, PFOS and PFOA concentrations over the suggested limits. In addition, at each study site, there were donors with high mercury and cadmium concentrations. Selecting young donors for transfusions or measurements of pollutants in donor blood may be a feasible approach to avoid exposure through blood transfusions to vulnerable groups of patients such as premature infants. Article in Journal/Newspaper Kirkenes Tromsø Wiley Online Library Tromsø Bergen Transfusion Medicine 30 3 201 209 |
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Abstract Objectives The aim of this study was to measure blood concentrations of environmental pollutants in Norwegian donors and evaluate the risk of pollutant exposure through blood transfusions. Background Transfused blood may be a potential source of exposure to heavy metals and organic pollutants and presents a risk to vulnerable patient groups such as premature infants. Methods/Materials Donors were randomly recruited from three Norwegian blood banks: in Bergen, Tromsø and Kirkenes. Selected heavy metals were measured in whole blood using inductively coupled plasma mass spectrometry (ICP‐MS), and perfluoroalkyl substances (PFAS) were measured in serum by ultrahigh‐pressure liquid chromatography coupled with a triple‐quadrupole mass spectrometer (UHPLC‐MS/MS). Results Almost 18% of blood donors had lead concentrations over the limit suggested for transfusions in premature infants (0.09 μmol/L). About 11% of all donors had mercury concentrations over the suggested limit of 23.7 nmol/L. Cadmium was higher than the limit, 16 nmol/L, in 4% of donors. Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) concentrations were over the suggested limit of 0.91 ng/mL in 68% and 100% of the donors, respectively. PFAS concentrations and heavy metal concentrations increased with donor's age. Conclusion A considerable percentage of donors had lead, PFOS and PFOA concentrations over the suggested limits. In addition, at each study site, there were donors with high mercury and cadmium concentrations. Selecting young donors for transfusions or measurements of pollutants in donor blood may be a feasible approach to avoid exposure through blood transfusions to vulnerable groups of patients such as premature infants. |
format |
Article in Journal/Newspaper |
author |
Averina, Maria Hervig, Tor Huber, Sandra Kjær, Mette Kristoffersen, Einar K. Bolann, Bjørn |
spellingShingle |
Averina, Maria Hervig, Tor Huber, Sandra Kjær, Mette Kristoffersen, Einar K. Bolann, Bjørn Environmental pollutants in blood donors: The multicentre Norwegian donor study |
author_facet |
Averina, Maria Hervig, Tor Huber, Sandra Kjær, Mette Kristoffersen, Einar K. Bolann, Bjørn |
author_sort |
Averina, Maria |
title |
Environmental pollutants in blood donors: The multicentre Norwegian donor study |
title_short |
Environmental pollutants in blood donors: The multicentre Norwegian donor study |
title_full |
Environmental pollutants in blood donors: The multicentre Norwegian donor study |
title_fullStr |
Environmental pollutants in blood donors: The multicentre Norwegian donor study |
title_full_unstemmed |
Environmental pollutants in blood donors: The multicentre Norwegian donor study |
title_sort |
environmental pollutants in blood donors: the multicentre norwegian donor study |
publisher |
Wiley |
publishDate |
2020 |
url |
http://dx.doi.org/10.1111/tme.12662 https://onlinelibrary.wiley.com/doi/pdf/10.1111/tme.12662 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/tme.12662 |
geographic |
Tromsø Bergen |
geographic_facet |
Tromsø Bergen |
genre |
Kirkenes Tromsø |
genre_facet |
Kirkenes Tromsø |
op_source |
Transfusion Medicine volume 30, issue 3, page 201-209 ISSN 0958-7578 1365-3148 |
op_rights |
http://creativecommons.org/licenses/by-nc/4.0/ |
op_doi |
https://doi.org/10.1111/tme.12662 |
container_title |
Transfusion Medicine |
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30 |
container_issue |
3 |
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201 |
op_container_end_page |
209 |
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1811640833195114496 |