Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans
Morbilliviruses, such as Cetacean morbillivirus (CeMV) or Phocine distemper virus (PDV), represent a growing threat for marine mammals on both hemispheres. Because free‐ranging animal populations strongly rely on natural resistance mechanisms, innate immunity‐related genes and virus cell entry recep...
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crwiley:10.1111/tan.13146 2024-09-15T18:30:26+00:00 Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans Stejskalova, K. Bayerova, Z. Futas, J. Hrazdilova, K. Klumplerova, M. Oppelt, J. Splichalova, P. Di Guardo, G. Mazzariol, S. Di Francesco, C. E. Di Francesco, G. Terracciano, G. Paiu, R.‐M. Ursache, T. D. Modry, D. Horin, P. Internal Grant Agency of the University of Veterinary and Pharmaceutical Sciences Brno (IGA VFU), Czech Republic 2017 http://dx.doi.org/10.1111/tan.13146 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Ftan.13146 https://onlinelibrary.wiley.com/doi/pdf/10.1111/tan.13146 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor HLA volume 90, issue 6, page 343-353 ISSN 2059-2302 2059-2310 journal-article 2017 crwiley https://doi.org/10.1111/tan.13146 2024-06-25T04:18:01Z Morbilliviruses, such as Cetacean morbillivirus (CeMV) or Phocine distemper virus (PDV), represent a growing threat for marine mammals on both hemispheres. Because free‐ranging animal populations strongly rely on natural resistance mechanisms, innate immunity‐related genes and virus cell entry receptor genes may represent key factors involved in susceptibility to CeMV in Cetaceans. Using the next generation sequencing technology, we have sequenced 11 candidate genes in two model species, Stenella coeruleoalba and Phocoena phocoena . Suitable single nucleotide polymorphism markers of potential functional importance, located in genes coding for basigin ( BSG , CD147 ), the signaling lymphocyte activating molecule ( SLAMF1 ), the poliovirus‐related receptor‐4 ( NECTIN4 , PVRL4 ), toll‐like receptors 3, 7, 8 ( TLR3 , TLR7 , TLR8 ), natural resistance‐associated macrophage protein ( SLC11A1 ) and natural cytotoxicity triggering receptor 1 ( NCR1 ), were identified in each model species, along with MHC‐DQB haplotypes unique for each species. This set of molecular markers represents a potentially useful tool for studying host genetic variation and susceptibility to morbillivirus infection in Cetaceans as well as for studying functionally important genetic diversity of selected Cetacean populations. Article in Journal/Newspaper Phocoena phocoena Wiley Online Library HLA 90 6 343 353 |
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Wiley Online Library |
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language |
English |
description |
Morbilliviruses, such as Cetacean morbillivirus (CeMV) or Phocine distemper virus (PDV), represent a growing threat for marine mammals on both hemispheres. Because free‐ranging animal populations strongly rely on natural resistance mechanisms, innate immunity‐related genes and virus cell entry receptor genes may represent key factors involved in susceptibility to CeMV in Cetaceans. Using the next generation sequencing technology, we have sequenced 11 candidate genes in two model species, Stenella coeruleoalba and Phocoena phocoena . Suitable single nucleotide polymorphism markers of potential functional importance, located in genes coding for basigin ( BSG , CD147 ), the signaling lymphocyte activating molecule ( SLAMF1 ), the poliovirus‐related receptor‐4 ( NECTIN4 , PVRL4 ), toll‐like receptors 3, 7, 8 ( TLR3 , TLR7 , TLR8 ), natural resistance‐associated macrophage protein ( SLC11A1 ) and natural cytotoxicity triggering receptor 1 ( NCR1 ), were identified in each model species, along with MHC‐DQB haplotypes unique for each species. This set of molecular markers represents a potentially useful tool for studying host genetic variation and susceptibility to morbillivirus infection in Cetaceans as well as for studying functionally important genetic diversity of selected Cetacean populations. |
author2 |
Internal Grant Agency of the University of Veterinary and Pharmaceutical Sciences Brno (IGA VFU), Czech Republic |
format |
Article in Journal/Newspaper |
author |
Stejskalova, K. Bayerova, Z. Futas, J. Hrazdilova, K. Klumplerova, M. Oppelt, J. Splichalova, P. Di Guardo, G. Mazzariol, S. Di Francesco, C. E. Di Francesco, G. Terracciano, G. Paiu, R.‐M. Ursache, T. D. Modry, D. Horin, P. |
spellingShingle |
Stejskalova, K. Bayerova, Z. Futas, J. Hrazdilova, K. Klumplerova, M. Oppelt, J. Splichalova, P. Di Guardo, G. Mazzariol, S. Di Francesco, C. E. Di Francesco, G. Terracciano, G. Paiu, R.‐M. Ursache, T. D. Modry, D. Horin, P. Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans |
author_facet |
Stejskalova, K. Bayerova, Z. Futas, J. Hrazdilova, K. Klumplerova, M. Oppelt, J. Splichalova, P. Di Guardo, G. Mazzariol, S. Di Francesco, C. E. Di Francesco, G. Terracciano, G. Paiu, R.‐M. Ursache, T. D. Modry, D. Horin, P. |
author_sort |
Stejskalova, K. |
title |
Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans |
title_short |
Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans |
title_full |
Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans |
title_fullStr |
Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans |
title_full_unstemmed |
Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans |
title_sort |
candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded cetaceans |
publisher |
Wiley |
publishDate |
2017 |
url |
http://dx.doi.org/10.1111/tan.13146 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Ftan.13146 https://onlinelibrary.wiley.com/doi/pdf/10.1111/tan.13146 |
genre |
Phocoena phocoena |
genre_facet |
Phocoena phocoena |
op_source |
HLA volume 90, issue 6, page 343-353 ISSN 2059-2302 2059-2310 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/tan.13146 |
container_title |
HLA |
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90 |
container_issue |
6 |
container_start_page |
343 |
op_container_end_page |
353 |
_version_ |
1810471905381056512 |