Salmon immunological defence and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis
Abstract The salmon louse Lepeophtheirus salmonis ( Lsal ) is an ectoparasitic copepod that exerts immunomodulatory and physiological effects on its host Atlantic salmon. Over 30 years of research on louse biology, control, host responses and the host‐parasite relationship has provided a plethora of...
Published in: | Parasite Immunology |
---|---|
Main Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2020
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1111/pim.12731 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fpim.12731 https://onlinelibrary.wiley.com/doi/pdf/10.1111/pim.12731 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/pim.12731 |
id |
crwiley:10.1111/pim.12731 |
---|---|
record_format |
openpolar |
spelling |
crwiley:10.1111/pim.12731 2023-12-03T10:19:15+01:00 Salmon immunological defence and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis Braden, Laura M. Monaghan, Sean J. Fast, Mark D. 2020 http://dx.doi.org/10.1111/pim.12731 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fpim.12731 https://onlinelibrary.wiley.com/doi/pdf/10.1111/pim.12731 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/pim.12731 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Parasite Immunology volume 42, issue 8 ISSN 0141-9838 1365-3024 Immunology Parasitology journal-article 2020 crwiley https://doi.org/10.1111/pim.12731 2023-11-09T14:00:52Z Abstract The salmon louse Lepeophtheirus salmonis ( Lsal ) is an ectoparasitic copepod that exerts immunomodulatory and physiological effects on its host Atlantic salmon. Over 30 years of research on louse biology, control, host responses and the host‐parasite relationship has provided a plethora of information on the intricacies of host resistance and parasite adaptation. Atlantic salmon exhibit temporal and spatial impairment of the immune system and wound healing ability during infection. This immunosuppression may render Atlantic salmon less tolerant to stress and other confounders associated with current management strategies. Contrasting susceptibility of salmonid hosts exists, and early pro‐inflammatory Th1 type responses are associated with resistance. Rapid cellular responses to larvae appear to tip the balance of the host‐parasite relationship in favour of the host, preventing severe immune‐physiological impacts of the more invasive adults. Immunological, transcriptomic, genomic and proteomic evidence suggests pathological impacts occur in susceptible hosts through modulation of host immunity and physiology via pharmacologically active molecules. Co‐evolutionary and farming selection pressures may have incurred preference of Atlantic salmon as a host for Lsal reflected in their interactome. Here, we review host‐parasite interactions at the primary attachment/feeding site, and the complex life stage‐dependent molecular mechanisms employed to subvert host physiology and immune responses. Article in Journal/Newspaper Atlantic salmon Wiley Online Library (via Crossref) Parasite Immunology 42 8 |
institution |
Open Polar |
collection |
Wiley Online Library (via Crossref) |
op_collection_id |
crwiley |
language |
English |
topic |
Immunology Parasitology |
spellingShingle |
Immunology Parasitology Braden, Laura M. Monaghan, Sean J. Fast, Mark D. Salmon immunological defence and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis |
topic_facet |
Immunology Parasitology |
description |
Abstract The salmon louse Lepeophtheirus salmonis ( Lsal ) is an ectoparasitic copepod that exerts immunomodulatory and physiological effects on its host Atlantic salmon. Over 30 years of research on louse biology, control, host responses and the host‐parasite relationship has provided a plethora of information on the intricacies of host resistance and parasite adaptation. Atlantic salmon exhibit temporal and spatial impairment of the immune system and wound healing ability during infection. This immunosuppression may render Atlantic salmon less tolerant to stress and other confounders associated with current management strategies. Contrasting susceptibility of salmonid hosts exists, and early pro‐inflammatory Th1 type responses are associated with resistance. Rapid cellular responses to larvae appear to tip the balance of the host‐parasite relationship in favour of the host, preventing severe immune‐physiological impacts of the more invasive adults. Immunological, transcriptomic, genomic and proteomic evidence suggests pathological impacts occur in susceptible hosts through modulation of host immunity and physiology via pharmacologically active molecules. Co‐evolutionary and farming selection pressures may have incurred preference of Atlantic salmon as a host for Lsal reflected in their interactome. Here, we review host‐parasite interactions at the primary attachment/feeding site, and the complex life stage‐dependent molecular mechanisms employed to subvert host physiology and immune responses. |
format |
Article in Journal/Newspaper |
author |
Braden, Laura M. Monaghan, Sean J. Fast, Mark D. |
author_facet |
Braden, Laura M. Monaghan, Sean J. Fast, Mark D. |
author_sort |
Braden, Laura M. |
title |
Salmon immunological defence and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis |
title_short |
Salmon immunological defence and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis |
title_full |
Salmon immunological defence and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis |
title_fullStr |
Salmon immunological defence and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis |
title_full_unstemmed |
Salmon immunological defence and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis |
title_sort |
salmon immunological defence and interplay with the modulatory capabilities of its ectoparasite lepeophtheirus salmonis |
publisher |
Wiley |
publishDate |
2020 |
url |
http://dx.doi.org/10.1111/pim.12731 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fpim.12731 https://onlinelibrary.wiley.com/doi/pdf/10.1111/pim.12731 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/pim.12731 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
Parasite Immunology volume 42, issue 8 ISSN 0141-9838 1365-3024 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/pim.12731 |
container_title |
Parasite Immunology |
container_volume |
42 |
container_issue |
8 |
_version_ |
1784266451677347840 |