Asthma and allergy in children with and without prior measles, mumps, and rubella vaccination
Abstract Background The existing literature on the association between measles vaccination and subsequent risk of allergic disease is inconclusive. The aim of this study was, therefore, to determine whether measles, mumps, and rubella ( MMR ) vaccination administered in early childhood was associate...
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crwiley:10.1111/pai.12391 2023-12-03T10:22:28+01:00 Asthma and allergy in children with and without prior measles, mumps, and rubella vaccination Timmermann, Clara Amalie Gade Osuna, Christa Elyse Steuerwald, Ulrike Weihe, Pál Poulsen, Lars K. Grandjean, Philippe National Institute of Environmental Health Sciences U.S. Environmental Protection Agency Miljøstyrelsen 2015 http://dx.doi.org/10.1111/pai.12391 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fpai.12391 https://onlinelibrary.wiley.com/doi/pdf/10.1111/pai.12391 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Pediatric Allergy and Immunology volume 26, issue 8, page 742-749 ISSN 0905-6157 1399-3038 Immunology Immunology and Allergy Pediatrics, Perinatology and Child Health journal-article 2015 crwiley https://doi.org/10.1111/pai.12391 2023-11-09T13:19:53Z Abstract Background The existing literature on the association between measles vaccination and subsequent risk of allergic disease is inconclusive. The aim of this study was, therefore, to determine whether measles, mumps, and rubella ( MMR ) vaccination administered in early childhood was associated with asthma and allergic diseases at ages 5, 7 and 13 yrs in a birth cohort. Methods In the Faroe Islands, 640 children were followed from birth. Follow‐up examinations at ages 5, 7 and 13 yrs included a physical examination and a maternal questionnaire about the child's health. At age 7, total and grass‐specific IgE was quantified in the child's serum, and at age 13, the children underwent skin prick tests ( SPT ). The child's vaccination card was reviewed at examinations. Results At age 5, 533 of 555 children had been vaccinated for MMR . After confounder adjustment, we found early life MMR vaccination to be associated with a two‐third reduction in the odds of asthma ( OR : 0.33, 95% CI : 0.12; 0.90) and hypersensitivity/allergy ( OR : 0.32, 95% CI : 0.11; 0.88) at age 5, and the substantially decreased odds of asthma were replicated at age 13 ( OR : 0.22, 95% CI : 0.08; 0.56). At age 7, serum total IgE was reduced by 62.8% ( CI 95%: −84.3%; −11.9%) in the vaccinated children. MMR vaccination was not significantly associated with allergic rhinoconjuctivitis symptoms, eczema, or SPT reactions at age 13. Conclusions MMR vaccination early in life may have a protective effect against allergy at least up to age 7 and against asthma through age 13 yrs. Article in Journal/Newspaper Faroe Islands Wiley Online Library (via Crossref) Faroe Islands Pediatric Allergy and Immunology 26 8 742 749 |
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Open Polar |
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Wiley Online Library (via Crossref) |
op_collection_id |
crwiley |
language |
English |
topic |
Immunology Immunology and Allergy Pediatrics, Perinatology and Child Health |
spellingShingle |
Immunology Immunology and Allergy Pediatrics, Perinatology and Child Health Timmermann, Clara Amalie Gade Osuna, Christa Elyse Steuerwald, Ulrike Weihe, Pál Poulsen, Lars K. Grandjean, Philippe Asthma and allergy in children with and without prior measles, mumps, and rubella vaccination |
topic_facet |
Immunology Immunology and Allergy Pediatrics, Perinatology and Child Health |
description |
Abstract Background The existing literature on the association between measles vaccination and subsequent risk of allergic disease is inconclusive. The aim of this study was, therefore, to determine whether measles, mumps, and rubella ( MMR ) vaccination administered in early childhood was associated with asthma and allergic diseases at ages 5, 7 and 13 yrs in a birth cohort. Methods In the Faroe Islands, 640 children were followed from birth. Follow‐up examinations at ages 5, 7 and 13 yrs included a physical examination and a maternal questionnaire about the child's health. At age 7, total and grass‐specific IgE was quantified in the child's serum, and at age 13, the children underwent skin prick tests ( SPT ). The child's vaccination card was reviewed at examinations. Results At age 5, 533 of 555 children had been vaccinated for MMR . After confounder adjustment, we found early life MMR vaccination to be associated with a two‐third reduction in the odds of asthma ( OR : 0.33, 95% CI : 0.12; 0.90) and hypersensitivity/allergy ( OR : 0.32, 95% CI : 0.11; 0.88) at age 5, and the substantially decreased odds of asthma were replicated at age 13 ( OR : 0.22, 95% CI : 0.08; 0.56). At age 7, serum total IgE was reduced by 62.8% ( CI 95%: −84.3%; −11.9%) in the vaccinated children. MMR vaccination was not significantly associated with allergic rhinoconjuctivitis symptoms, eczema, or SPT reactions at age 13. Conclusions MMR vaccination early in life may have a protective effect against allergy at least up to age 7 and against asthma through age 13 yrs. |
author2 |
National Institute of Environmental Health Sciences U.S. Environmental Protection Agency Miljøstyrelsen |
format |
Article in Journal/Newspaper |
author |
Timmermann, Clara Amalie Gade Osuna, Christa Elyse Steuerwald, Ulrike Weihe, Pál Poulsen, Lars K. Grandjean, Philippe |
author_facet |
Timmermann, Clara Amalie Gade Osuna, Christa Elyse Steuerwald, Ulrike Weihe, Pál Poulsen, Lars K. Grandjean, Philippe |
author_sort |
Timmermann, Clara Amalie Gade |
title |
Asthma and allergy in children with and without prior measles, mumps, and rubella vaccination |
title_short |
Asthma and allergy in children with and without prior measles, mumps, and rubella vaccination |
title_full |
Asthma and allergy in children with and without prior measles, mumps, and rubella vaccination |
title_fullStr |
Asthma and allergy in children with and without prior measles, mumps, and rubella vaccination |
title_full_unstemmed |
Asthma and allergy in children with and without prior measles, mumps, and rubella vaccination |
title_sort |
asthma and allergy in children with and without prior measles, mumps, and rubella vaccination |
publisher |
Wiley |
publishDate |
2015 |
url |
http://dx.doi.org/10.1111/pai.12391 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fpai.12391 https://onlinelibrary.wiley.com/doi/pdf/10.1111/pai.12391 |
geographic |
Faroe Islands |
geographic_facet |
Faroe Islands |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
Pediatric Allergy and Immunology volume 26, issue 8, page 742-749 ISSN 0905-6157 1399-3038 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/pai.12391 |
container_title |
Pediatric Allergy and Immunology |
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26 |
container_issue |
8 |
container_start_page |
742 |
op_container_end_page |
749 |
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1784270397373415424 |